SGS: Sun Hur - Nucleic acid-induced self-assembly – foreign nucleic acid sensors and beyond

Sun Hur lab seeks to unravel the underlying principles of innate immunity that allow the body to detect and respond to invading pathogens. Specifically, Hur and her team are investigating how the vertebrate immune system discriminates between self and non-self on the basis of RNA structure and modifications. Using structural and biochemical approaches, the team focuses on immune receptors and modulators of the antiviral innate immune response. The team is also investigating other aspects of nucleic acid biology, such as transcriptional reprogramming and post-transcriptional regulation, during the development and maturation of the vertebrate immune system. Their work has implications for better understanding and treating viral infections and other diseases, such as autoimmune inflammatory disorders and cancer.

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• The Hur lab at Harvard
• The Hur lab at BCH