Group Leader

Dr. Erika Pearce
Dr. Erika Pearce
Senior Group Leader and Director
Phone:+49 761 5108-713

Lab Erika Pearce

Assistant: Kimberly Mueller phone: +49 761 5108-450 Email:

Selected publications

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL (2015)
Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Chang CH*, Qiu J*, O’Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJW, Tonc E, Schreiber RD, Pearce EJ, and Pearce EL (2015)
Metabolic competition in the tumor microenvironment is a driver of cancer progression
O’Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CC, Buck MD, QiuJ, Smith AM, Lam WY, DiPlatoLM, Hsu FF, Birnbaum MJ, Pearce EJ, and Pearce EL (2014)
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development
Pearce EL, Poffenberger M, Chang CH, Jones RG (2013)
Fueling Immunity: Insights into metabolism and lymphocyte function
Chang CH, Curtis JD, Maggi Jr. LB, Faubert B, Villarino AV, O’Sullivan D, Huang SC, van der Windt GJW, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, and Pearce EL (2013)
Post-Transcriptional Control Of T Cell Effector Function By Aerobic Glycolysis
van der Windt GJW, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, and Pearce EL (2012)
Mitochondrial Respiratory Capacity Is A Critical Regulator of CD8(+) T Cell Memory Development

Laboratory Erika Pearce

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Laboratory Erika Pearce

Research in our laboratory focuses on understanding the cellular and molecular mechanisms that control immune responses, with a particular emphasis on how metabolism governs this process. Currently our work is focused on the role of metabolism in regulating memory T cell development and effector T cell function. My laboratory is committed to using a wide variety of approaches to address key questions in immune cell metabolism in vitro and in vivo, and how this impacts protective immunity to infection and cancer. We hope that our work will allow us to develop new ways to target T cell longevity and function through metabolism, with a long-term goal of mitigating human disease.

“Fitting metabolism and immunity together, to a T”

Interview with Erika Pearce about her scientific discoveries and personal journey in Journal of Cell Biology 217(6), July 7, 2018. [more]

In a nutshell: Research by the Lab of Erika Pearce

Erika Pearce - How Does Metabolism Influence the Function of Different T Cell Types?

On not only find the video but rather additional information (such as chapters, subtitles, related literature as well as additional videos by Erika Pearce).

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