Laboratory Erika Pearce

Laboratory Erika Pearce


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Erika Pearce, Bloomberg Distinguished Professor
Johns Hopkins University
School of Medicine
600 N. Wolfe Street
Baltimore MD 21287

Research in our laboratory focuses on understanding the cellular and molecular mechanisms that control immune responses, with a particular emphasis on how metabolism governs this process. Currently our work is focused on the role of metabolism in regulating memory T cell development and effector T cell function. My laboratory is committed to using a wide variety of approaches to address key questions in immune cell metabolism in vitro and in vivo, and how this impacts protective immunity to infection and cancer. We hope that our work will allow us to develop new ways to target T cell longevity and function through metabolism, with a long-term goal of mitigating human disease.

In a nutshell: Research by the Lab of Erika Pearce

Erika Pearce - How Does Metabolism Influence the Function of Different T Cell Types?

The research presented in this video investigates how the metabolism of the T cells influences the development of effector and memory T cells by blending in vitro and in vivo approaches.

On not only find the video but rather additional information (such as chapters, subtitles, related literature as well as additional videos by Erika Pearce).

Selected Publications

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL (2019)
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Cell Metabolism 30(2), 352-363.e8.
O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL (2019)
Metabolic interventions in the immune response to cancer
Nature Reviews Immunology 19, 324-335.
Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ & Pearce EL (2017)
Mitochondrial Priming by CD28
Cell 171(2), 385-397.
Buck MD, Sowell RT, Kaech SM, Pearce EL (2017)
Metabolic Instruction of Immunity
Cell 169(4), 570-586.
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL (2015)
Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Cell 166(1), 63-76.
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