Laboratory Edward Pearce
Current Affiliation: Bloomberg Distinguished Professor at the Johns Hopkins University, Baltimore, USA
The laboratory emphasizes two overlapping areas of research:
Cells of the innate immune system play important roles in tissue hemostasis and in defense against infection. To a great extent the ability of these cells to serve multiple functions reflects their ability to enact different gene expression programs in response to distinct extra- and intra-cellular activating signals. Recent work has revealed that innate cell activation is highly dependent on metabolic reprogramming. The laboratory is focused on elucidating the mechanisms involved in innate immune cell metabolic reprogramming and the underlying reasons why different types of metabolism are essential to support different activation states in these cells.