Michael Mihlan

Postdoc
Department-independent Research Groups
Lämmermann Lab
248

Research Interests

I’m focusing on cellular and humoral effectors of the innate immune system during inflammation. My main aim is to investigate how their activity is controlled and how they interact with each other for a beneficial immune response. Using various technologies, I’m bridging biochemistry and cell biology. Finally, I want to understand mechanisms of inflammatory diseases like hyperresponsiveness or infections.

Curriculum Vitae

  • Since 2015 Postdoctoral research fellow at the MPI-IE Freiburg
  • 2011-2015  Postdoctoral research fellow at the IGBMC Illkirch, France
  • 2006-2011  PhD in immunology at the Leibniz Institute for Natural Product Research and Infection Biology (HKI) Jena, Germany
  • 2005 Master of Science in Human Biology, University of Greifswald, Germany

 

Selected publications

  • Mihlan M, Blom AM, Kupreishvili K, Lauer N, Stelzner K, Bergström F, Niessen HW, Zipfel PF (2011): Monomeric C-reactive protein modulates classic complement activation on necrotic cells. FASEB J. 25(12), pp. 4198-210. DOI 10.1096/fj.11-186460
  • Mihlan M, Stippa S, JozsiM, Zipfel PF (2009): Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H. Cell Death Differ. 16(12), pp. 1630-40. DOI: 10.1038/cdd.2009.103
  • Zhang Z, Meszaros G, He WT, Xu Y, Magliarelli HF, Mailly L, Mihlan M, et al. (2017): Protein Kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 214(9), pp. 2671-2693. DOI: 10.1084/jem.20162040
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