Cancers have a high frequency of somatic alterations on chromatin regulators and growth factor signaling pathways. Cells transmit extracellular information from the membrane to the nucleus which involves using cell-surface receptors and signaling pathways. By utilizing growth factor signaling pathways, gene expression can be controlled via the extracellular environment, but the involvement of chromatin regulators is largely unknown. My work will focus to uncover the contribution of mixed lineage leukemias (MLLs) histone methyltransferase complex in cancer cell signaling regulation.
- IMPRS PhD student in the lab of Prof. Dr. Marc Timmers, Centre for Clinical Research, University Freiburg Medical Centre, Germany (2018 - Present)
- Master student in Graduate Institute of Biomedical Sciences, Division of Microbiology at Chang Gung University, Taiwan (2016 - 2018)
- Undergraduate student in Biomedical Sciences at Chang Gung University, Taiwan (2012 – 2016)
- Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IYF, Yeh YM, Chen CD, Li HP, Luo JD, Tan BCM, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP, Chang YS. (2017): APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nature Communication 8, 465. DOI: 10.1038/s41467-017-00493-9