Publications of Erika L. Pearce

Journal Article (68)

2018
Journal Article
Villa, M.; Jing, Q.; Pearce, E. L.: A Sweet Deal for Diabetes. Trends in Endocrinology and Metabolism 29, pp. 1 - 2 (2018)
2017
Journal Article
Gubin, M. M.; Zhang, X.; Schuster, H.; Caron, E.; Ward, J. P.; Noguchi, T.; Ivanova, Y.; Hundal, J.; Arthur, C. D.; Krebber, W.-J. et al.; Mulder, G. E.; Toebes, M.; Vesely, M. D.; Lam, S. S. K.; Korman, A. J.; Allison, J. P.; Freeman, G. J.; Sharpe, A. H.; Pearce, E. L.; Schumacher, T. N.; Aebersold, R.; Rammensee, H.-G.; Melief, C. J. M.; Mardis, E. R.; Gillanders, W. E.; Artyomov, M. N.; Schreiber, R. D.: Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, pp. 577 - 581 (2017)
Journal Article
Geltink, R. I. K.; O’Sullivan, D.; Corrado, M.; Bremser, A.; Buck, M. D.; Buescher, J. M.; Firat, E.; Zhu, X.; Niedermann, G.; Caputa, G. et al.; Kelly, B.; Warthorst, U.; Rensing-Ehl, A.; Kyle, R. L.; Vandersarren, L.; Curtis, J. D.; Patterson, A. E.; Lawless, S.; Grzes, K.; Qiu, J.; Sanin, D. E.; Kretz, O.; Huber, T. B.; Janssens, S.; Lambrecht, B. N.; Rambold, A.; Pearce, E. J.; Pearce, E. L.: Mitochondrial Priming by CD28. Cell 171, pp. 385 - 397 (2017)
Journal Article
Puleston, D.; Mateo, V.; Pearce, E. L.: Ancillary Activity: Beyond Core Metabolism in Immune Cells. Cell Metabolism 26, pp. 131 - 141 (2017)
Journal Article
Buck, M.; Sowell, R. T.; Kaech, S. M.; Pearce, E. L.: Metabolic Instruction of Immunity. Cell 169, pp. 570 - 586 (2017)
Journal Article
Klein-Geltink, R.; O'Sullivan, D.; Pearce, E. L.: Caught in the cROssfire: GSH Controls T Cell Metabolic Reprogramming. Immunity 46, pp. 525 - 527 (2017)
2016
Journal Article
Huang, S. C.-C.; Smith, A. M.; Everts, B.; Colonna, M.; Pearce, E. L.; Schilling, J. D.; Pearce, E. J.: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation. Immunity 45, pp. 817 - 830 (2016)
Journal Article
O'Sullivan, D.; Kelly, B.; Pearce, E. L.: When Hexokinase Gets that NAG-ing Feeling. Cell Metabolism 24, pp. 198 - 200 (2016)
Journal Article
Lam, W. Y.; Becker, A. M.; Kennerly, K. M.; Wong, R.; Curtis, J. D.; Llufrio, E. M.; McCommis, K. S.; Fahrmann, J.; Pizzato, H. A.; Nunley, R. M. et al.; Lee, J.; Wolfgang, M. J.; Patti, G. J.; Finck, B. N.; Pearce, E. L.; Bhattacharya, D.: Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity 45, pp. 60 - 73 (2016)
Journal Article
Buck, M. D.; O’Sullivan, D.; Geltink, R. I. K.; Curtis, J. D.; Chang, C.-H.; Sanin, D. E.; Qiu, J.; Kretz, O.; Braas, D.; van der Windt, G. J.W. et al.; Chen, Q.; Huang, S. C.-C.; O’Neill, C. M.; Edelson, B. T.; Pearce, E. J.; Sesaki, H.; Huber, T. B.; Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell 166, pp. 63 - 76 (2016)
Journal Article
Kaiko, G. E.; Ryu, S. H.; Koues, O. I.; Collins, P. L.; Solnica-Krezel, L.; Pearce, E. J.; Pearce, E. L.; Oltz, E. M.; Stappenbeck, T. S.: The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell 167, pp. 1708 - 1720 (2016)
Journal Article
Monticelli, L. A.; Buck, M. D.; Flamar, A.-L.; Saenz, S. A.; Wojno, E. D. T.; Yudanin, N. A.; Osborne, L. C.; Hepworth, M. R.; Tran, S. V.; Rodewald, H.-R. et al.; Shah, H.; Cross, J. R.; Diamond, J. M.; Cantu, E.; Christie, J. D.; Pearce, E. L.; Artis, D.: Arginase 1 is an innate lymphoid-cell intrinisic metabolic checkpoint controlling type 2 inflammation. Nature Immunology 17, pp. 656 - 665 (2016)
Journal Article
Chang, C.-H.; Pearce, E. L.: Emerging concepts of T cell metabolism as a target of immunotherapy. Nature Immunology 17, pp. 364 - 368 (2016)
Journal Article
van der Windt, G. J.W.; Chang, C.; Pearce, E. L.: Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer. Current Protocols in Immunology 113, pp. 16B1.3 - 16B.14 (2016)
2015
Journal Article
Chang, C.-H.; Qiu, J.; O'Sullivan, D.; Buck, M.; Noguchi, T.; Curtis, J. D.; Chen, Q.; Gindin, M.; Gubin, M. M.; van der Windt, G. J.W. et al.; Tonc, E.; Schreiber, R. D.; Pearce, E. J.; Pearce, E. L.: Metabolic Competition in the Tumor Microenvironment is a Driver of Cancer Progression. Cell 162, pp. 1229 - 1241 (2015)
Journal Article
Buck, M. D.; O'Sullivan, D.; Pearce, E. L.: T cell metabolism drives immunity. Journal of Experimental Medicine 212, pp. 1345 - 1360 (2015)
Journal Article
O'Sullivan, D.; Pearce, E. L.: Immunology, Expanding the roles of metabolism in T cells. Science 348, pp. 976 - 977 (2015)
Journal Article
O'Sullivan, D.; Pearce, E. L.: Targeting T cell metabolism for therapy. Trends in Immunology 36, pp. 71 - 80 (2015)
Journal Article
Blagih, J.; Coulombe, F.; Vincent, E. E.; Dupuy, F.; Galicia-Vázquez, G.; Yurchenko, E.; Raissi, T. C.; van der Windt, G. J.W.; Viollet, B.; Pearce, E. L. et al.; Pelletier, J.; Piccirillo, C. A.; Krawczyk, C. M.; Divangahi, M.; Jones, R. G.: The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vitro. Immunity 42, pp. 41 - 54 (2015)
2014
Journal Article
Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L. et al.; Green, D. R.; Jones, D. P.; Virgin, H. W.; Ahmed, R.; Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L.; Green, D. R.; Jones, D. P.; Ahmed, R.: Autophagy is essential for effector CD8+ T cell survival and memory formation. Nature Immunology 15, pp. 1152 - 1161 (2014)
Journal Article
O'Sullivan, D.; Pearce, E. L.: Fatty acid sysnthesis tips the TH17-Treg cell balance. Nature Medicine 20, pp. 1235 - 1236 (2014)
Journal Article
Walsh, M. C.; Pearce, E. L.; Cejas, P. J.; Lee, J.; Wang, L.-S.; Choi, Y.: IL-18 synergivzes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals. The Journal of Immunology 193, pp. 3992 - 4001 (2014)
Journal Article
Amiel, E.; Everts, B.; Fritz, D.; Beauchamp, S.; Ge, B.; Pearce, E. L.; Pearce, E. J.: Mechanistic target of rapamycin inhition extend cellular lifespan in dendritic cells by preserving mitochondrial function. The Journal of Immunology 193, pp. 2821 - 2830 (2014)
Journal Article
Chou, C.; Pinto, A. K.; Jonathen, C.; Persaud, S. P.; Cella, M.; Lin, C.-C.; Edelson, B. T.; Allen, P. M.; Colonna, M.; Pearce, E. L. et al.; Diamond, M. S.; Egawa, T.: c-Myc-induced transcription factor AP4 is requeired for host protection mediated by CD8+ T Cells. Nature Immunology 15, pp. 884 - 893 (2014)
Journal Article
Huang, S. C.-C.; Everts, B.; Ivanova, Y.; O'Sullivan, D.; Nascimento, M.; Smith, A. M.; Beatty, W.; Love-Gregory, L.; Lam, W. Y.; O'Neill, C. M. et al.; Yan, C.; Du, H.; Abumrad, N. A.; Urban, J. F. J.; Artyomov, M. N.; Pearce, E. J.; Pearce, E. L.: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 15, pp. 846 - 855 (2014)
Journal Article
O'Sullivan, D.; van der Windt, G. J.W.; Huang, S. C.-C.; Curtis , J.; Chang, C.-H.; Buck, M. D.; Qiu, J.; Smith, A. M.; Lam, W. Y.; DiPlato, L. M. et al.; Hsu, F.-F.; Birnbaum, M. J.; Pearce, E. J.; Pearce, E. L.: Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, pp. 75 - 88 (2014)
Journal Article
Everts, B.; Amiel, E.; Huang, S. C.-C.; Smith, A. M.; Chang, C.-H.; Lam, W. Y.; Redmann, V.; Freitas, T. C.; Blagih, J.; van der Windt, G. J. W. et al.; Artyomov, M. N.; Jones, R. G.; Pearce, E. L.; Pearce, E. J.: TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nature Immunology 15, pp. 323 - 332 (2014)
2013
Journal Article
Pearce, E. L.; Poffenberger, M. C.; Chang, C.-H.; Jones, R. G.: Fueling immunity: insights into metabolism and lymphocyte function. Science 342, p. 1242454 (2013)
Journal Article
van der Windt, G. J. W.; O’Sullivan, D.; Everts, B.; Huang, S. C.-C.; Buck, M. D.; Curtis, J. D.; Chang, C.-H.; Smith, A. M.; Ai, T.; Faubert, B. et al.; Jones, R. G.; Pearce, E. J.; Pearce, E. L.: CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proceedings of the National Academy of Sciences of the United States of America 153, pp. 1239 - 1259 (2013)
Journal Article
Chang, C.-H.; Curtis, J. D.; Maggi Jr., L. B.; Faubert, B.; Villarino, A. V.; O’Sullivan, D.; Huang, S. C.-C.; van der Windt, G. J.W.; Blagih, J.; Qiu, J. et al.; Weber, J. D.; Pearce, E. J.; Jones, R. G.; Pearce, E. L.: Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, pp. 1239 - 1251 (2013)
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