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Journal Article (68)

  1. 2021
    Journal Article
    Stanczak, M. A.; Sanin, P. D. E.; Apostolova, P.; Nerz, G.; Lampaki, D.; Hofmann, M.; Steinmann, D.; Krohn-Grimberghe, M.; Thimme, R.; Mittler, G. et al.; Waller, C. F.; Pearce, E. J.; Pearce, E. L.: IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications 12, p. 2133 (2021)
  2. Journal Article
    Villa, M.; Stanczak, M. A.; Pearce, E. L.: How to make a better T cell: in vivo CRISPR screens have some answers. Cell 184, pp. 1135 - 1136 (2021)
  3. Journal Article
    Corrado, M.; Samardžić, D.; Giacomello, M.; Rana, N.; Pearce, E. L.; Scorrano, L.: Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death and Differentiation (2021)
  4. Journal Article
    Kelly, B.; Carrizo, G. E.; Edwards-Hicks, J.; Sanin, P. D. E.; Stanczak, M. A.; Priesnitz, C.; Flachsmann, L. J.; Jonathan, D. C.; Mittler, G.; Musa, Y. et al.; Becker, T.; Büscher, J. M.; Pearce, E. L.: Sulfur sequestration promotes multicellularity during nutrient limitation. Nature, pp. 1 - 6 (2021)
  5. 2020
    Journal Article
    Edwards-Hicks, J.; Mitterer, M.; Pearce, E. L.; Buescher, J. M.: Metabolic Dynamics of In Vitro CD8+ T Cell Activation. Metabolites 11, p. 12 (2020)
  6. Journal Article
    Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.; Quintana, A.; Jonathan, C.; Clapes, T.; Grzes, K.; Kabat, A.; Ryan, K.; Annette, E. P.; Klein-Geltink, R.; Amulic, B.; Steward, C. G.; Strathdee, D.; Trompouki, E.; O'Sullivan, D.; Pearce, E. J.; Pearce, E. L.: Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metabolism 32, pp. 981 - 995 (2020)
  7. Journal Article
    Uhl, F. M.; Chen, S.; O'Sullivan, D.; Edwards-Hicks, J.; Richter, G.; Haring, E.; Andrieux, G.; Halbach, S.; Apostalova, P.; Büscher, J. M. et al.; Duquesne, S.; Melchinger, W.; Sauer, B.; Shoumariyeh, K.; Schmitt-Graeff, A.; Kreutz, M.; Lübbert, M.; Duyster, J.; Brummer, T.; Boerries, M.; Madl, T.; Blazar, B. R.; Groß, O.; Pearce, E. L.; Zeiser, R.: Metabolic reprogramming of donor T cells enhances graf-versus-leukemia effects in mice and humans. Science Translational Medicine 12, p. eabb8969 (2020)
  8. Journal Article
    Kelly, B.; Pearce, E. L.: Amino Assets: How Amino Acids Support Immunity. Cell Metabolism 32, pp. 154 - 175 (2020)
  9. Journal Article
    Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.; Kabat, A.; Stanczak, M.; Curtis, J.; Hässler, F.; Uhl, F. M.; Fabri, M.; Zeiser, R.; Pearce, E. J.; Pearce, E. L.: Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nature Metabolism 2, pp. 703 - 716 (2020)
  10. Journal Article
    Haring, E.; Uhl, F. M.; Andrieux, G.; Proietti, M.; Bulashevska, A.; Sauer, B.; Braun, L. M.; de Gomez, E. V.; Esser, P. R.; Martin, S. F. et al.; Pfeifer, D.; Follo, M.; Schmitt-Graeff, A.; Büscher, J. M.; Duyster, J.; Grimbacher, B.; Boerries, M.; Pearce, E. L.; Zeiser, R.; Apostolova, P.: Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica (2020)
  11. Journal Article
    Milam, A. A. V.; Bartleson, J. M.; Buck, M. D.; Chang, C.-H.; Sergushichev, A.; Donermeyer, D. L.; Lam, W. Y.; Pearce, E. L.; Artyomov, M. N.; Allen, P. M.: Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells. ImmunoHorizons 4, pp. 485 - 497 (2020)
  12. Journal Article
    Almeida, R. R.; de Vieira, R. S.; Castoldi, A.; Terra, F. F.; Melo, A. C. L.; Canesso, M. C. C.; Lemos, L.; Cipelli, M.; Rana, N.; Hiyane, M. I. et al.; Pearce, E. L.; Martins, F. d. S.; de Câmara, A. M. C. F. &. N. O. S.: Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity. British Journal of Cancer 123, pp. 534 - 541 (2020)
  13. Journal Article
    Puleston, D.; Pearce, E. L.: Appetite for Arginine: Metabolic Control of Macrophage Hunger. Cell Metabolism 31, pp. 441 - 442 (2020)
  14. Journal Article
    Angiari, S.; Runtsch, M. C.; Sutton, C. E.; Palsson-McDermott, E. M.; Kelly, B.; Rana, N.; Kane, H.; Papadopoulou, G.; Pearce, E. L.; Mills, K. H.G. et al.; O'Neill, L. A.J.: Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+-T Cell Pathogenicity and Suppresses Autoimmunity. Cell Metabolism 31, pp. 391 - 405 (2020)
  15. Journal Article
    Field, C.; Baixauli Celda, F.; Puleston, D.; Kyle, R.; Alana, C.; Sanin, P. D. E.; Hippen, K. L.; Loschi, M.; Thangavelu, G.; Corrado, M. et al.; Edwards-Hicks, J.; Grzes, K.; Pearce, E. J.; Blazar, B. R.; Pearce, E. L.: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function. Cell Metabolism 31, pp. 422 - 437 (2020)
  16. Journal Article
    Castoldi, A.; Monteiro, L. B.; van Bakker, N. T.; Sanin, D. E.; Rana, N.; Corrado, M.; Cameron, A. M.; Hässler, F.; Matsushita, M.; Caputa, G. et al.; Geltink, R. I. K.; Büscher, J.; Edwards-Hicks, J.; Pearce, E. L.; Pearce, E. J.: Triacylglycerol synthesis enhances macrophage inflammatory function. Nature Communications 11, pp. 1 - 11 (2020)
  17. Journal Article
    Kapoor, T.; Corrado, M.; Pearce, E. L.; Pearce, E. J.; Grosschedl, R.: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports 10 (2020)
  18. Journal Article
    Ramamoorthy, S.; Kometani, K.; Herman, J. S.; Bayer, M.; Boller, S.; Edwards-Hicks, J.; Ramachandran, H.; Li, R.; Klein-Geltink, R.; Pearce, E. L. et al.; Grün, D.; Grosschedl, R.: EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes and Development 34, pp. 1503 - 1519 (2020)
  19. 2019
    Journal Article
    O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, pp. 324 - 334 (2019)
  20. Journal Article
    Cameron, A. M.; Castoldi, A.; Sanin, D. E.; Flachsmann, L. J.; Field, C. S.; Puleston, D. J.; Kyle, R. L.; Patterson, A.; Hassler, F.; Buescher, J. M. et al.; Kelly, B.; Pearce, E. L.; Pearce, E. J.: Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage. Nature Immunology 20, pp. 420 - 432 (2019)
  21. Journal Article
    Mateo, V.; Baixauli Celda, F.; Pearce, E. L.: Potassium shapes antitumor immunity. Science 363, pp. 1395 - 1396 (2019)
  22. Journal Article
    Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.; Zhang, Y.; Flachsmann, L. J.; Field, C. S.; Patterson, A. E.; Scherer, S.; Alfei, F.; Baixauli, F.; Austin, S. K.; Kelly, B.; Matsushita, M.; Curtis, J. D.; Grzes, K. M.; Villa, M.; Corrado, M.; Sanin, D. E.; Qiu, J.; Pällman, N.; Paz, K.; Maccari, M. E.; Blazar, B. R.; Mittler, G.; Büscher, J.; Zehn, D.; Rospert, S.; Pearce, E. J.; Balabanov, S.; Pearce, E. L.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, pp. 1 - 12 (2019)
  23. Journal Article
    Qui, J.; Mateo, V.; Sanin, D. E.; Buck, M. D.; O'Sullivan, D.; Ching, R.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Curtis, J.; Kyle, R.; Van Teijlingen, N.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, pp. 2063 - 2074 (2019)
  24. 2018
    Journal Article
    Sanin, D. E.; Matsushita, M.; Klein-Geltink, R.; Grzes, K.; van Bakker, N. T.; Corrado, M.; Kabat, A.; Buck, M. D.; Qiu, J.; Lawless, S. J. et al.; Cameron, A.; Villa, M.; Baixauli Celda, F.; Patterson, A. E.; Hässler, F.; Curtis, J. D.; O’Neill, C. M.; O'Sullivan, D.; Wu, D.; Mittler, G.; Huang, S. C.-C.; Pearce, E. L.; Pearce, E. J.: Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity 49, pp. 1021 - 1033 (2018)
  25. Journal Article
    Mathew, N. R.; Baumgartner, F.; Braun, L.; O'Sullivan, D.; Thomas, S.; Waterhouse, M.; Müller, T. A.; Hanke, K.; Taromi, S.; Apostolova, P. et al.; Illert, A. L.; Melchinger, W.; Duquesne, S.; Schmitt-Graeff, A.; Osswald, L.; Yan, K.-L.; Weber, A.; Tugues, S.; Spath, S.; Pfeifer, D.; Follo, M.; Claus, R.; Lübbert, M.; Rummelt, C.; Bertz, H.; Wäsch, R.; Haag, J.; Schmidts, A.; Schultheiss, M.; Bettinger, D.; Thimme, R.; Ullrich, E.; Tanriver, Y.; Vuong, G. L.; Arnold, R.; Hemmati, P.; Wolf, D.; Ditschkowski, M.; Jilg, C.; Wilhelm, K.; Leiber, C.; Gerull, S.; Halter, J.; Lengerke, C.; Pabst, T.; Schroeder, T.; Kobbe, G.; Rösler, W.; Doostkam, S.; Meckel, S.; Stabla, K.; Metzelder, S. K.; Halbach, S.; Brummer–, T.; Hu, Z.; Dengjel, J.; Hackanson, B.; Schmid, C.; Holtick, U.; Scheid, C.; Spyridonidis, A.; Stölzel, F.; Ordemann, R.; Müller, L. P.; Sicre-de-Fontbrune, F.; Ihorst, G.; Kuball, J.; Ehlert, J. E.; Feger, D.; Wagner, E.-M.; Cahn, J.-Y.; Schnell, J.; Kuchenbauer, F.; Bunjes, D.; Chakraverty, R.; Richardson, S.; Gill, S.; Kröger, N.; Ayuk, F.; Vago–, L.; Ciceri–, F.; Müller, A. M.; Kondo, T.; Teshima, T.; Klaeger, S.; Kuster, B.; Kim, D.; Weisdorf, D.; van der Velden, W.; Dörfel, D.; Bethge, W.; Hilgendorf, I.; Hochhaus, A.; Andrieux, G.; Börries, M.; Busch, H.; Magenau, J.; Reddy, P.; Labopin, M.; Antin, J. H.; Henden, A. S.; Hill–, G. R.; Kennedy, G. A.; Bar, M.; Sarma, A.; McLornan, D.; Mufti, G.; Oran, B.; Rezvani, K.; Shah, O.; Negrin, R. S.; Nagler, A.; Prinz, M.; Burchert, A.; Neubauer, A.; Beelen, D.; Mackensen, A.; von Bubnoff, N.; Herr, W.; Becher, B.; Socié, G.; Caligiuri, M. A.; Ruggiero–, E.; Bonini–, C.; Häcker, G.; Duyster, J.; Finke, J.; Pearce, E. L.; Blazar, B. R.; Zeiser, R.: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT-3-ITD-mutant leukemia cells. Nature Medicine 24, pp. 282 - 291 (2018)
  26. Journal Article
    Prestipino, A.; Emhardt, A. J.; Aumann, K.; O'Sullivan, D.; Gorantla, S. P.; Duquesne, S.; Melchinger, W.; Braun, L.; Vuckovic, S.; Boerries, M. et al.; Busch, H.; Halbach, S.; Pennisi, S.; Poggio, T.; Apostolova, P.; Veratti, P.; Hettich, M.; Niedermann, G.; Bartholomä, M.; Shoumariyeh, K.; Jutzi, J. S.; Wehrle, J.; Dierks, C.; Becker, H.; Schmitt-Graeff, A.; Follo, M.; Pfeifer, D.; Rohr, J.; Fuchs, S.; Ehl, S.; Hartl, F. A.; Minguet, S.; Miething, C.; Heidel, F. H.; Kröger, N.; Triviai, I.; Brummer, T.; Finke, J.; Illert, A. L.; Ruggiero, E.; Bonini, C.; Duyster, J.; Pahl, H. L.; Lane, S. W.; Hill, G. R.; Blazar, B. R.; von Bubnoff, N.; Pearce, E. L.; Zeiser, R.: Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine 10 (2018)
  27. Journal Article
    Klein-Geltink, R.; Kyle, R. L.; Pearce, E. L.: Unraveling the Complex Interplay Between T Cell Metabolism and Function. Annual Reviews of Immunology 36, pp. 461 - 488 (2018)
  28. Journal Article
    Pearce, E. J.; Pearce, E. L.: Immunometabolism in 2017: Driving immunity: all roads lead to metabolism. Nature Reviews Immunology 18, pp. 81 - 82 (2018)
  29. Journal Article
    Piragyte, I.; Clapes, T.; Polyzou, A.; Geltink, R. I. K.; Lefkopoulos, S.; Yin, N.; Cauchy, P.; Curtis, J. D.; Klaeylé, L.; Langa, X. et al.; Beckmann, C. C. A.; Wlodarski, M. W.; Müller, P.; Essen, D. V.; Rambold, A.; Kapp, F. G.; Mione, M.; Buescher, J. M.; Pearce, E. L.; Polyzos, A.; Trompouki, E.: A metabolic interplay coordinatd by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature Communications 9, p. 3090 (2018)
  30. Journal Article
    Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function. Trends in Immunology 39, pp. 6 - 18 (2018)
 
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