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Journal Article (56)

  1. 2020
    MPG.PuRe
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    Kelly, B.; Pearce, E. L.: Amino Assets: How Amino Acids Support Immunity. Cell Metabolism 32 (2020)
  2. MPG.PuRe
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    Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.; Kabat, A.; Stanczak, M.; Curtis, J.; Hässler, F.; Uhl, F. M.; Fabri, M.; Zeiser, R.; Pearce, E. J.; Pearce, E. L.: Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nature Metabolism (2020)
  3. MPG.PuRe
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    Journal Article
    Haring, E.; Uhl, F. M.; Andrieux, G.; Proietti, M.; Bulashevska, A.; Sauer, B.; Braun, L. M.; de Gomez, E. V.; Esser, P. R.; Martin, S. F. et al.; Pfeifer, D.; Follo, M.; Schmitt-Graeff, A.; Büscher, J. M.; Duyster, J.; Grimbacher, B.; Boerries, M.; Pearce, E. L.; Zeiser, R.; Apostolova, P.: Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica (2020)
  4. MPG.PuRe
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    Puleston, D.; Pearce, E. L.: Appetite for Arginine: Metabolic Control of Macrophage Hunger. Cell Metabolism 31, pp. 441 - 442 (2020)
  5. MPG.PuRe
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    Angiari, S.; Runtsch, M. C.; Sutton, C. E.; Palsson-McDermott, E. M.; Kelly, B.; Rana, N.; Kane, H.; Papadopoulou, G.; Pearce, E. L.; Mills, K. H.G. et al.; O'Neill, L. A.J.: Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+-T Cell Pathogenicity and Suppresses Autoimmunity. Cell Metabolism 31, pp. 391 - 405 (2020)
  6. MPG.PuRe
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    Field, C.; Baixauli Celda, F.; Puleston, D.; Kyle, R.; Alana, C.; Sanin, P. D. E.; Hippen, K. L.; Loschi, M.; Thangavelu, G.; Corrado, M. et al.; Edwards-Hicks, J.; Grzes, K.; Pearce, E. J.; Blazar, B. R.; Pearce, E. L.: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function. Cell Metabolism 31, pp. 422 - 437 (2020)
  7. 2019
    MPG.PuRe
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    Journal Article
    O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, pp. 324 - 334 (2019)
  8. MPG.PuRe
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    Cameron, A. M.; Castoldi, A.; Sanin, D. E.; Flachsmann, L. J.; Field, C. S.; Puleston, D. J.; Kyle, R. L.; Patterson, A.; Hassler, F.; Buescher, J. M. et al.; Kelly, B.; Pearce, E. L.; Pearce, E. J.: Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage. Nature Immunology 20, pp. 420 - 432 (2019)
  9. MPG.PuRe
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    Mateo, V.; Baixauli Celda, F.; Pearce, E. L.: Potassium shapes antitumor immunity. Science 363, pp. 1395 - 1396 (2019)
  10. MPG.PuRe
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    Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.; Zhang, Y.; Flachsmann, L. J.; Field, C. S.; Patterson, A. E.; Scherer, S.; Alfei, F.; Baixauli, F.; Austin, S. K.; Kelly, B.; Matsushita, M.; Curtis, J. D.; Grzes, K. M.; Villa, M.; Corrado, M.; Sanin, D. E.; Qiu, J.; Pällman, N.; Paz, K.; Maccari, M. E.; Blazar, B. R.; Mittler, G.; Büscher, J.; Zehn, D.; Rospert, S.; Pearce, E. J.; Balabanov, S.; Pearce, E. L.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, pp. 1 - 12 (2019)
  11. MPG.PuRe
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    Qui, J.; Mateo, V.; Sanin, D. E.; Buck, M. D.; O'Sullivan, D.; Ching, R.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Curtis, J.; Kyle, R.; Van Teijlingen, N.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, pp. 2063 - 2074 (2019)
  12. 2018
    MPG.PuRe
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    Sanin, D. E.; Matsushita, M.; Klein-Geltink, R.; Grzes, K.; van Bakker, N. T.; Corrado, M.; Kabat, A.; Buck, M. D.; Qiu, J.; Lawless, S. J. et al.; Cameron, A.; Villa, M.; Baixauli Celda, F.; Patterson, A. E.; Hässler, F.; Curtis, J. D.; O’Neill, C. M.; O'Sullivan, D.; Wu, D.; Mittler, G.; Huang, S. C.-C.; Pearce, E. L.; Pearce, E. J.: Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity 49, pp. 1021 - 1033 (2018)
  13. MPG.PuRe
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    Mathew, N. R.; Baumgartner, F.; Braun, L.; O'Sullivan, D.; Thomas, S.; Waterhouse, M.; Müller, T. A.; Hanke, K.; Taromi, S.; Apostolova, P. et al.; Illert, A. L.; Melchinger, W.; Duquesne, S.; Schmitt-Graeff, A.; Osswald, L.; Yan, K.-L.; Weber, A.; Tugues, S.; Spath, S.; Pfeifer, D.; Follo, M.; Claus, R.; Lübbert, M.; Rummelt, C.; Bertz, H.; Wäsch, R.; Haag, J.; Schmidts, A.; Schultheiss, M.; Bettinger, D.; Thimme, R.; Ullrich, E.; Tanriver, Y.; Vuong, G. L.; Arnold, R.; Hemmati, P.; Wolf, D.; Ditschkowski, M.; Jilg, C.; Wilhelm, K.; Leiber, C.; Gerull, S.; Halter, J.; Lengerke, C.; Pabst, T.; Schroeder, T.; Kobbe, G.; Rösler, W.; Doostkam, S.; Meckel, S.; Stabla, K.; Metzelder, S. K.; Halbach, S.; Brummer–, T.; Hu, Z.; Dengjel, J.; Hackanson, B.; Schmid, C.; Holtick, U.; Scheid, C.; Spyridonidis, A.; Stölzel, F.; Ordemann, R.; Müller, L. P.; Sicre-de-Fontbrune, F.; Ihorst, G.; Kuball, J.; Ehlert, J. E.; Feger, D.; Wagner, E.-M.; Cahn, J.-Y.; Schnell, J.; Kuchenbauer, F.; Bunjes, D.; Chakraverty, R.; Richardson, S.; Gill, S.; Kröger, N.; Ayuk, F.; Vago–, L.; Ciceri–, F.; Müller, A. M.; Kondo, T.; Teshima, T.; Klaeger, S.; Kuster, B.; Kim, D.; Weisdorf, D.; van der Velden, W.; Dörfel, D.; Bethge, W.; Hilgendorf, I.; Hochhaus, A.; Andrieux, G.; Börries, M.; Busch, H.; Magenau, J.; Reddy, P.; Labopin, M.; Antin, J. H.; Henden, A. S.; Hill–, G. R.; Kennedy, G. A.; Bar, M.; Sarma, A.; McLornan, D.; Mufti, G.; Oran, B.; Rezvani, K.; Shah, O.; Negrin, R. S.; Nagler, A.; Prinz, M.; Burchert, A.; Neubauer, A.; Beelen, D.; Mackensen, A.; von Bubnoff, N.; Herr, W.; Becher, B.; Socié, G.; Caligiuri, M. A.; Ruggiero–, E.; Bonini–, C.; Häcker, G.; Duyster, J.; Finke, J.; Pearce, E. L.; Blazar, B. R.; Zeiser, R.: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT-3-ITD-mutant leukemia cells. Nature Medicine 24, pp. 282 - 291 (2018)
  14. MPG.PuRe
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    Prestipino, A.; Emhardt, A. J.; Aumann, K.; O'Sullivan, D.; Gorantla, S. P.; Duquesne, S.; Melchinger, W.; Braun, L.; Vuckovic, S.; Boerries, M. et al.; Busch, H.; Halbach, S.; Pennisi, S.; Poggio, T.; Apostolova, P.; Veratti, P.; Hettich, M.; Niedermann, G.; Bartholomä, M.; Shoumariyeh, K.; Jutzi, J. S.; Wehrle, J.; Dierks, C.; Becker, H.; Schmitt-Graeff, A.; Follo, M.; Pfeifer, D.; Rohr, J.; Fuchs, S.; Ehl, S.; Hartl, F. A.; Minguet, S.; Miething, C.; Heidel, F. H.; Kröger, N.; Triviai, I.; Brummer, T.; Finke, J.; Illert, A. L.; Ruggiero, E.; Bonini, C.; Duyster, J.; Pahl, H. L.; Lane, S. W.; Hill, G. R.; Blazar, B. R.; von Bubnoff, N.; Pearce, E. L.; Zeiser, R.: Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine 10 (2018)
  15. MPG.PuRe
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    Klein-Geltink, R.; Kyle, R. L.; Pearce, E. L.: Unraveling the Complex Interplay Between T Cell Metabolism and Function. Annual Reviews of Immunology 36, pp. 461 - 488 (2018)
  16. MPG.PuRe
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    Pearce, E. J.; Pearce, E. L.: Immunometabolism in 2017: Driving immunity: all roads lead to metabolism. Nature Reviews Immunology 18, pp. 81 - 82 (2018)
  17. MPG.PuRe
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    Piragyte, I.; Clapes, T.; Polyzou, A.; Geltink, R. I. K.; Lefkopoulos, S.; Yin, N.; Cauchy, P.; Curtis, J. D.; Klaeylé, L.; Langa, X. et al.; Beckmann, C. C. A.; Wlodarski, M. W.; Müller, P.; Essen, D. V.; Rambold, A.; Kapp, F. G.; Mione, M.; Buescher, J. M.; Pearce, E. L.; Polyzos, A.; Trompouki, E.: A metabolic interplay coordinatd by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature Communications 9, p. 3090 (2018)
  18. MPG.PuRe
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    Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function. Trends in Immunology 39, pp. 6 - 18 (2018)
  19. MPG.PuRe
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    Villa, M.; Jing, Q.; Pearce, E. L.: A Sweet Deal for Diabetes. Trends in Endocrinology and Metabolism 29, pp. 1 - 2 (2018)
  20. 2017
    MPG.PuRe
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    Gubin, M. M.; Zhang, X.; Schuster, H.; Caron, E.; Ward, J. P.; Noguchi, T.; Ivanova, Y.; Hundal, J.; Arthur, C. D.; Krebber, W.-J. et al.; Mulder, G. E.; Toebes, M.; Vesely, M. D.; Lam, S. S. K.; Korman, A. J.; Allison, J. P.; Freeman, G. J.; Sharpe, A. H.; Pearce, E. L.; Schumacher, T. N.; Aebersold, R.; Rammensee, H.-G.; Melief, C. J. M.; Mardis, E. R.; Gillanders, W. E.; Artyomov, M. N.; Schreiber, R. D.: Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, pp. 577 - 581 (2017)
  21. MPG.PuRe
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    Geltink, R. I. K.; O’Sullivan, D.; Corrado, M.; Bremser, A.; Buck, M. D.; Buescher, J. M.; Firat, E.; Zhu, X.; Niedermann, G.; Caputa, G. et al.; Kelly, B.; Warthorst, U.; Rensing-Ehl, A.; Kyle, R. L.; Vandersarren, L.; Curtis, J. D.; Patterson, A. E.; Lawless, S.; Grzes, K.; Qiu, J.; Sanin, D. E.; Kretz, O.; Huber, T. B.; Janssens, S.; Lambrecht, B. N.; Rambold, A.; Pearce, E. J.; Pearce, E. L.: Mitochondrial Priming by CD28. Cell 171, pp. 385 - 397 (2017)
  22. MPG.PuRe
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    Puleston, D.; Mateo, V.; Pearce, E. L.: Ancillary Activity: Beyond Core Metabolism in Immune Cells. Cell Metabolism 26, pp. 131 - 141 (2017)
  23. MPG.PuRe
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    Buck, M.; Sowell, R. T.; Kaech, S. M.; Pearce, E. L.: Metabolic Instruction of Immunity. Cell, pp. 570 - 586 (2017)
  24. MPG.PuRe
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    Klein-Geltink, R.; O'Sullivan, D.; Pearce, E. L.: Caught in the cROssfire: GSH Controls T Cell Metabolic Reprogramming. Immunity 46, pp. 525 - 527 (2017)
  25. 2016
    MPG.PuRe
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    Huang, S. C.-C.; Smith, A. M.; Everts, B.; Colonna, M.; Pearce, E. L.; Schilling, J. D.; Pearce, E. J.: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation. Immunity 45, pp. 817 - 830 (2016)
  26. MPG.PuRe
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    Journal Article
    O'Sullivan, D.; Kelly, B.; Pearce, E. L.: When Hexokinase Gets that NAG-ing Feeling. Cell Metabolism 24, pp. 198 - 200 (2016)
  27. MPG.PuRe
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    Lam, W. Y.; Becker, A. M.; Kennerly, K. M.; Wong, R.; Curtis, J. D.; Llufrio, E. M.; McCommis, K. S.; Fahrmann, J.; Pizzato, H. A.; Nunley, R. M. et al.; Lee, J.; Wolfgang, M. J.; Patti, G. J.; Finck, B. N.; Pearce, E. L.; Bhattacharya, D.: Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity 45, pp. 60 - 73 (2016)
  28. MPG.PuRe
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    Buck, M. D.; O’Sullivan, D.; Geltink, R. I. K.; Curtis, J. D.; Chang, C.-H.; Sanin, D. E.; Qiu, J.; Kretz, O.; Braas, D.; van der Windt, G. J.W. et al.; Chen, Q.; Huang, S. C.-C.; O’Neill, C. M.; Edelson, B. T.; Pearce, E. J.; Sesaki, H.; Huber, T. B.; Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell 166, pp. 63 - 76 (2016)
  29. MPG.PuRe
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    Kaiko, G. E.; Ryu, S. H.; Koues, O. I.; Collins, P. L.; Solnica-Krezel, L.; Pearce, E. J.; Pearce, E. L.; Oltz, E. M.; Stappenbeck, T. S.: The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell 167, pp. 1708 - 1720 (2016)
  30. MPG.PuRe
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    Monticelli, L. A.; Buck, M. D.; Flamar, A.-L.; Saenz, S. A.; Wojno, E. D. T.; Yudanin, N. A.; Osborne, L. C.; Hepworth, M. R.; Tran, S. V.; Rodewald, H.-R. et al.; Shah, H.; Cross, J. R.; Diamond, J. M.; Cantu, E.; Christie, J. D.; Pearce, E. L.; Artis, D.: Arginase 1 is an innate lymphoid-cell intrinisic metabolic checkpoint controlling type 2 inflammation. Nature Immunology 17, pp. 656 - 665 (2016)
 
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