Group Leader

Dr. Eirini Trompouki
Dr. Eirini Trompouki
Group Leader
Phone:+49 761 5108-550

Lab Eirini Trompouki

Selected Publications

1.
Piragyte I, Clapes T, Polyzou A, Klein Geltink RA, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A & Trompouki E (2018)
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
2.
Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI (2018)
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
3.
Clapes T, Lefkopoulos S, Trompouki E (2016)
Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance
4.
Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I (2016)

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

5.
Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI (2011)
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

Laboratory Eirini Trompouki

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Laboratory Eirni Trompouki

Hematopoiesis is the process of generating new cells of all the blood lineages. Exceedingly rare hematopoietic stem cells (HSCs) are responsible for maintaining the balance between different blood lineages and replenishing the system in case of stress such as infection, trauma or irradiation. Signal transduction pathways continuously deliver information to the cells by mediating the actions of signaling transcription factors.

We are particularly interested in inflammatory pathways that have been recently implicated in HSC quiescence and regeneration. HSCs were thought to respond to inflammatory signals indirectly, just to replenish immune hematopoietic cells. Only lately, it has been proven that HSCs can directly sense and respond to inflammatory signals, not only in cases of infection but also under steady state conditions. Acute inflammatory signaling affects HSC quiescence and chronic exposure can lead to HSC exhaustion and may cause hematopoietic malignancies.

Using zebrafish and mice as model organisms we want to understand how these pathways control HSC quiescence, and affect hematopoietic differentiation and regeneration. We are mainly interested in studying how inflammatory signals formulate the transcriptional landscape of HSCs. The ultimate goal is to understand how we can manipulate hematopoietic stem cells and improve hematopoietic outcomes during stress and disease.

 
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