Laboratory Eirni Trompouki
Hematopoiesis is the process of generating new cells of all the blood lineages. Exceedingly rare hematopoietic stem cells (HSCs) are responsible for maintaining the balance between different blood lineages and replenishing the system in case of stress such as infection, trauma or irradiation. Signal transduction pathways continuously deliver information to the cells by mediating the actions of signaling transcription factors.
We are particularly interested in inflammatory pathways that have been recently implicated in HSC quiescence and regeneration. HSCs were thought to respond to inflammatory signals indirectly, just to replenish immune hematopoietic cells. Only lately, it has been proven that HSCs can directly sense and respond to inflammatory signals, not only in cases of infection but also under steady state conditions. Acute inflammatory signaling affects HSC quiescence and chronic exposure can lead to HSC exhaustion and may cause hematopoietic malignancies.
Using zebrafish and mice as model organisms we want to understand how these pathways control HSC quiescence, and affect hematopoietic differentiation and regeneration. We are mainly interested in studying how inflammatory signals formulate the transcriptional landscape of HSCs. The ultimate goal is to understand how we can manipulate hematopoietic stem cells and improve hematopoietic outcomes during stress and disease.