Embryonic patterning via gradients of BMP signaling
Research report (imported) 2003 - Max Planck Institute of Immunobiology and Epigenetics
The Bone morphogenetic proteins (BMP) belong to the TGF-ß family of secreted growth factors and regulate fundamental events in early development of vertebrate as well as invertebrate embryos. In particular, the formation of a functional BMP signalling gradient, established by the localised secretion of BMP antagonists, is essential for the determination of cell fate along the future dorsoventral or back-to-belly body axis. Michale Oelgeschläger and his team have identified a number of new genes that are regulated by the BMP signalling gradient in Xenopus laevis. One of these genes is involved in the regulation of cellular movements rather than cell fate determination and might help to unravel the relationship of cellular movements and cell fate determination during early embryonic development.