Wound healing proceeds along a precisely orchestrated sequence of events. Failure to properly execute these events causes wound healing pathologies and chronic wounds. Strikingly, many patients with metabolic disorders or inflammatory diseases, such as diabetes or obesity, will be facing wound healing difficulties in the course of their life and, as a potential consequence, amputation of lower extremities. The molecular and cellular mechanisms underlying impaired wound healing and their link to metabolic dysregulation are not well understood. Therefore, by using well-established in vivo models of wound healing and epithelial regeneration in Drosophila, I aim to create a functional map of acute and chronic wound metabolism with a specific focus on adaptations of Insulin signaling during wound healing.