Reyna Edith Rosales Alvarez

from Toluca, Mexico
IMPRS doctoral researcher since Sept 2019 in Grün lab

Research interests
Molecular variability across individual cells is an intrinsic feature caused by both deterministic and stochastic mechanisms. Gene expression noise, given by stochastic effects in mRNA synthesis, is a major contributor of molecular variability. During cell differentiation, stem cells express early differentiating genes in a random way, promoting cell bias to commit into a particular cell lineage. However, it is still not clear which is the role of gene expression variability in cell fate decision. To gain insights into this question, I am performing in silico analyses of single-cell transcriptomic data. I aim to develop a computational approach for reliable quantification of gene expression variability and to further characterize how this variability changes across differentiation trajectories.
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