Research interests
The combinatorial nature of histone posttranslational modifications (PTM) as well as their ever-growing number, led to the hypothesis of the ‘histone code’. PTM profiles indeed reflect a certain chromatin state, which indicates a partial responsibility of histone PTMs regarding regulation and function of chromatin states. Misregulation in these PTM profiles have already been shown to impact pathways related to a number of diseases like cancer. Through LC-MS, I aim to monitor changes of all prominent histone H3 marks as well as changes in the protein composition of chromatin, during epithelial to mesenchymal transition using MCF10a breast cancer cells as a model.
