Thomas Boehm receives the 2021 Heinrich Wieland Prize

Max Planck researcher honored for groundbreaking research

October 18, 2021

This year’s Heinrich Wieland Prize is awarded to immunologist Thomas Boehm from the Max Planck Institute for Immunobiology and Epigenetics in Freiburg. With this internationally renowned research prize, endowed with 100,000 euros, the Boehringer Ingelheim Foundation recognizes Boehm’s pioneering contributions to our current understanding of the development and evolution of the immune system in vertebrates.

The outstanding scientific work of immunologist Thomas Boehm is being honored once again. He is recognized by the Boehringer Ingelheim Foundation for his pioneering contributions to our understanding of the immune system. His research focuses primarily on the development and function of the thymus and T cells as well as the evolution of adaptive immunity.

Using an impressive spectrum of model organisms, he discovered general design principles of cellular immunity in vertebrates, shifting existing paradigms, and offering entirely new perspectives on adaptive immunity.

He identified the transcription factor Foxn1 as an evolutionarily conserved master regulator of epithelial cell differentiation in the thymus. In the thymus, haematopoietic progenitor cells arriving from the bone marrow develop into T cells, which are equipped with all the necessary facilities to fight off pathogens. Boehm was able to show that Foxn1 is necessary for the development of the thymus and thus for immunity in vertebrates. “With this finding from Thomas Boehm, it was possible for the first time to genetically study how T cells develop instead of just describing it. This advance from a then early career researcher had a significant impact on the field of immunology”, says F.-Ulrich Hartl, chair of the Wieland Prize selection committee.

Design principles of adaptive immunity revealed

In studies dedicated to the evolution of the thymus, he also discovered the long-sought thymus equivalent in jawless vertebrates, resolving a century-old debate about the nature of the immune system in this vertebrate lineage. Using comparative studies of phylogenetically diverse model organisms ranging from lampreys to sharks to mice and humans, he reconstructed the evolutionary trajectory of the genetic networks controlling T cell development and recapitulated their step-wise development in vivo. Thus, he was able to identify common design features of the immune systems of all vertebrates and the fundamentals of their adaptability.

Key publications by the Boehm Lab

Thomas Boehm also discovered an olfactory mechanism by which animals as different as fish and mammals evaluate the composition of major histocompatibility complex (MHC) molecules. All cells of the body are equipped with MHC molecules on their surface. They differ from individual to individual and serve in a sense as identification cards, because they help the immune system to distinguish self from non-self. Thomas Boehm showed that MHC peptides not only assist decision-making in the immune system, but also signal genetic relatedness during mate selection, helping to explain why vertebrates are capable of maintaining a diverse repertoire of MHC genes.

Paradigm shifts in evolutionary immunology

Most recently, Thomas Boehm uncovered that deep-sea anglerfishes have switched off-key players of their adaptive immunity, such as the RAG genes, which orchestrate antigen receptor assembly. Switching off adaptive immunity was previously considered to be highly unlikely, as innate and adaptive immune systems were thought to have become inextricably intertwined over vertebrate evolution. The immunogenetic adaptation in these species enables males to permanently fuse with their much larger female partners, a form of tissue chimaerism that is otherwise unknown in nature. These results demonstrate that co-evolution of innate and adaptive immunity can come to an abrupt end, breaking a central paradigm of evolutionary immunology. However, the findings also indicate that new forms of innate immunity can evolve to protect vertebrates from infection, potentially relevant for a better understanding of organ transplantation.

The award ceremony will take place on 21 October, following a scientific symposium organized by the Boehringer Ingelheim Foundation. At the event, which will be held in English at Schloss Nymphenburg in Munich, the prize winner of 2020, Professor Craig M. Crews from Yale University in the United States, will be presented the award as well.

Award Symposium

The Wieland Prize winner at Berlin Science Week

As a special highlight, 2021 Wieland Laureate Thomas Boehm will take part in a digital panel discussion addressing the wider public. The event takes place online on 2 November from 4-5 pm CET as part of Berlin Science Week. This event will be in German and includes a discussion between Thomas Boehm and renowned philosopher Professor Markus Gabriel of the University of Bonn, Germany, about human vulnerability in the context of disease and society.

Berlin Science Week - Panel discussion: New hope by immune research

CV Thomas Boehm

Thomas Boehm studied human medicine at the Johann Wolfgang Goethe University in Frankfurt am Main, and received additional training at Columbia University in New York (USA) and the Royal Marsden Hospital in London (England). Thomas Boehm graduated in Frankfurt in 1982, where he also qualified as a university lecturer in 1988. After clinical training in pediatrics and human genetics, and research at the MRC Laboratory of Molecular Biology in Cambridge (England), he took up professorships for Medical Molecular Biology at the Albert-Ludwigs University Freiburg and Experimental Therapy at the German Cancer Research Center in Heidelberg. Since January 1998, Thomas Boehm is director at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and an Honorary Professor at the Medical Faculty of the University of Freiburg. Thomas Boehm is a member of several learned societies, including the European Molecular Biology Organization, the German Academy of Sciences, the Heidelberg Academy of Sciences and Humanities as well as the American Academy of Arts and Sciences. In 2018, he has been appointed Chairman of Scientific Council of the Paul Ehrlich-Foundation. He is the recipient of several awards, including Paul Ehrlich and Ludwig Darmstaedter Prize for Young Researchers, the Gottfried-Wilhelm-Leibniz Prize of the German Science Foundation, the Ernst Jung Prize for Medicine and the German Immunology Award.

The Heinrich Wieland Prize

The Heinrich Wieland Prize is an internationally renowned science award honoring outstanding research on biologically active molecules and systems in the fields of chemistry, biochemistry, and physiology as well as their clinical importance. The 100,000-euro prize is named after the Nobel Laureate Heinrich Otto Wieland (1877–1957) and has been awarded annually since 1964. Among the awardees – selected by a scientific Board of Trustees – are four subsequent Nobel Laureates. Since 2011, the prize has been endowed by the Boehringer Ingelheim Foundation.

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