Publications of Edward J. Pearce

Journal Article (67)

2016
Journal Article
Kannan, Y.; Perez-Lloret, J.; Li, Y.; Entwistle, L. J.; Khoury, H.; Papoutsopoulou, S.; Mahmood, R.; Mansour, N. R.; Huang, S. C.-C.; Pearce, E. J. et al.; de Carvalho, L. P. S.; Ley, S. C.; Wilson, M. S.: TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology. PLoS Pathogens 12, p. e1005783 (2016)
Journal Article
Sergushichev, A. A.; Loboda, A. A.; Jha, A. K.; Vincent, E. E.; Driggers, E. M.; Jones, R. G.; Pearce, E. J.; Artyomov, M. N.: GAM: a web-service for integrated transcriptional and metabolic network analysis. Nucleic Acids Research 125, pp. 4699 - 4713 (2016)
Journal Article
Sergushichev, A. A.; Loboda, A. A.; Jha, A. K.; Vincent, E. E.; Driggers, E. M.; Jones, R. G.; Pearce, E. J.; Artyomov, M. N.: GAM: a web-service for integrated transcriptional and metabolic network analysis. Nucleic Acids Research (London), pp. W194 - W200 (2016)
2015
Journal Article
Chang, C.-H.; Qiu, J.; O'Sullivan, D.; Buck, M.; Noguchi, T.; Curtis, J. D.; Chen, Q.; Gindin, M.; Gubin, M. M.; van der Windt, G. J.W. et al.; Tonc, E.; Schreiber, R. D.; Pearce, E. J.; Pearce, E. L.: Metabolic Competition in the Tumor Microenvironment is a Driver of Cancer Progression. Cell 162, pp. 1229 - 1241 (2015)
Journal Article
Tussiwand, R.; Everts, B.; Grajales-Reyes, G. E.; Kretzer, N. M.; Iwata, A.; Bagaitkar, J.; Wu, X.; Wong, R.; Anderson, D. A.; Murphy, T. L. et al.; Pearce, E. J.; Murphy, K. M.: Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42, pp. 916 - 928 (2015)
Journal Article
Fairfax, K. C.; Everts, B.; Amiel, E.; Smith, A. M.; Schramm, G.; Haas, H.; Randolph, G. J.; Taylor, J. J.; Pearce, E. J.: IL-4-Secreting secondary Tfh cells arise from memory T cells, not persisting Tfh cells, not persisting Tfh cells, through a B cell dependent mechanism. The Journal of Immunology 194, pp. 2999 - 3010 (2015)
Journal Article
Jha, A.K.; Huang, S.C.; Sergushichev, A.; Lampropoulo, V.; Ivanova , Y.; Loginicheva , E.; Chielewski, K.; Stewart, K.M.; Ashali, J.; Everts, B. et al.; Pearce, E.J.; Driggers, E.M.; Artyomov, A.: Network integration of parallel metabolomics and transcirptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42, pp. 419 - 430 (2015)
Journal Article
Monin, L.; Griffiths, K. L.; Lam, W. Y.; Gopal, R.; Kang, D. D.; Ahmed, M.; Rajamanickam, A.; Cruz-Lagunas, A.; Zúñiga, J.; Babu, S. et al.; Kolls, J. K.; Mitreva, M.; Rosa, B. A.; Ramos-Payan, R.; Morrison, T. E.; Murray, P. J.; Rangel-Moreno, J.; Pearce, E. J.; Khader, S. A.: Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. Journal of Clinical Investigation 125, pp. 4699 - 4713 (2015)
Journal Article
Pearce, E. J.; Everts, B.: Dendritic cell metabolism. Nature Reviews Immunology, pp. 18 - 29 (2015)
Journal Article
Pearce, E. J.; Huang, S. C.-C.: The metabolic control of schistosome egg production. Cellular Microbiology 17, pp. 796 - 801 (2015)
2014
Journal Article
Amiel, E.; Everts, B.; Fritz, D.; Beauchamp, S.; Ge, B.; Pearce, E. L.; Pearce, E. J.: Mechanistic target of rapamycin inhition extend cellular lifespan in dendritic cells by preserving mitochondrial function. The Journal of Immunology 193, pp. 2821 - 2830 (2014)
Journal Article
Huang, S. C.-C.; Everts, B.; Ivanova, Y.; O'Sullivan, D.; Nascimento, M.; Smith, A. M.; Beatty, W.; Love-Gregory, L.; Lam, W. Y.; O'Neill, C. M. et al.; Yan, C.; Du, H.; Abumrad, N. A.; Urban, J. F. J.; Artyomov, M. N.; Pearce, E. J.; Pearce, E. L.: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 15, pp. 846 - 855 (2014)
Journal Article
O'Sullivan, D.; van der Windt, G. J.W.; Huang, S. C.-C.; Curtis , J.; Chang, C.-H.; Buck, M. D.; Qiu, J.; Smith, A. M.; Lam, W. Y.; DiPlato, L. M. et al.; Hsu, F.-F.; Birnbaum, M. J.; Pearce, E. J.; Pearce, E. L.: Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, pp. 75 - 88 (2014)
Journal Article
Everts, B.; Amiel, E.; Huang, S. C.-C.; Smith, A. M.; Chang, C.-H.; Lam, W. Y.; Redmann, V.; Freitas, T. C.; Blagih, J.; van der Windt, G. J. W. et al.; Artyomov, M. N.; Jones, R. G.; Pearce, E. L.; Pearce, E. J.: TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nature Immunology 15, pp. 323 - 332 (2014)
Journal Article
Everts, B.; Pearce, E. J.: Metabolic Control of Dendritic Cell Activation and Function: Recent Advances and Clinical Implications. Frontiers in immunology 5, p. 203 (2014)
Journal Article
Gautier, E. L.; Ivanov, S.; Williams, J. W.; Huang, S. C.-C.; Marcelin, G.; Fairfax, K.; Wang, P. L.; Francis, J. S.; Leone, P.; Wilson, D. B. et al.; Artyomov, M. N.; Pearce, E. J.; Randolph, G. J.: Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. Journal of Experimental Medicine 211, pp. 1525 - 1531 (2014)
Journal Article
Nascimento, M.; Huang, S. C.; Smith, A.; Everts, B.; Lam, W.; Bassity, E.; Gautier, E. L.; Randolph, G. J.; Pearce, E. J.: Ly6Chi Monocyte Recruitment is Responsible for Th2 Associated Host-Protective Maxrophage Accumulation in Liver Inflammation due to Schistosomiasis. PLoS Pathogens 10, p. e1004282 (2014)
Journal Article
Reese, T.A.; Wakeman, B.S.; Choi, H.S.; Hufford, M.M.; Huang, S.C.; Zhang, X.; Buck, M.D.; Jezewski, A.; Kambal, A.; Liu, C.Y. et al.; Goel, G.; Murray, P.J.; Xavier, R.J.; Kaplan, M.H.; Renne, R.; Speck, S.H.; Artyomov, M.N.; Pearce, E. J.; Virgin, H.W.: Helminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter. Science 345, pp. 573 - 577 (2014)
2013
Journal Article
van der Windt, G. J. W.; O’Sullivan, D.; Everts, B.; Huang, S. C.-C.; Buck, M. D.; Curtis, J. D.; Chang, C.-H.; Smith, A. M.; Ai, T.; Faubert, B. et al.; Jones, R. G.; Pearce, E. J.; Pearce, E. L.: CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proceedings of the National Academy of Sciences of the United States of America 153, pp. 1239 - 1259 (2013)
Journal Article
Chang, C.-H.; Curtis, J. D.; Maggi Jr., L. B.; Faubert, B.; Villarino, A. V.; O’Sullivan, D.; Huang, S. C.-C.; van der Windt, G. J.W.; Blagih, J.; Qiu, J. et al.; Weber, J. D.; Pearce, E. J.; Jones, R. G.; Pearce, E. L.: Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, pp. 1239 - 1251 (2013)
Journal Article
Pearce, E. L.; Pearce, E. J.: Metabolic pathways in immune cell activation and quiscence. Immunity 38, pp. 633 - 643 (2013)
Journal Article
McCarthy, S. A.; Mufson, R. A.; Pearce, E. J.; Rathmell, J. C.; Howcroft, T. K.: Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biology & Therapy 14, pp. 315 - 318 (2013)
Journal Article
Taylor, C. M.; Wang, Q.; Rosa, B. A.; Huang, S. C.-C.; Powell, K.; Schedl, T.; Pearce, E. J.; Abubucker, S.; Mitreva, M.: Discovery of Anthelminitic Drug Targets and Drugs Using Chokepoints in Nematode Metabolic Pathways. PLoS Pathogens 9, p. e1003505 (2013)
2012
Journal Article
Amiel, E.; Everts, B.; Freitas, T. C.; King, I. L.; Curtis, J. D.; Pearce, E. L.; Pearce, E. J.: Inhibition of mechanistic target of repamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. The Journal of Immunology 189, pp. 2151 - 2158 (2012)
Journal Article
Everts, B.; Amiel, E.; van der Windt, G. J. W.; Freitas, T. C.; Chott, R.; Yarasheski, K. E.; Pearce, E. L.; Pearce, E. J.: Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120, pp. 1422 - 1431 (2012)
Journal Article
van der Windt, G. J.W.; Everts, B.; Chang, C.-H.; Curtis, J. D.; Freitas, T. C.; Amiel, E.; Pearce, E. J.; Pearce, E. L.: Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, pp. 68 - 78 (2012)
Journal Article
Everts, B.; Hussaarts, L.; Driessen, N. N.; Meevissen, M. H.J.; Schramm, G.; van der Ham, A. J.; van der Hoeven, B.; Scholzen, T.; Burgdorf, S.; Mohrs, M. et al.; Pearce, E. J.; Hokke, C. H.; Haas, H.; Smits, H. H.; Yazdanbakhsh, M.: Schistosome-derived omega-1 drives Th2 polarizationm by suppressing protein synthesis following internalization by the mannose receptor. Journal of Experimental Medicine 209, pp. 1753 - 1767 (2012)
Journal Article
Fairfax, K. C.; Amiel, E.; King, I. L.; Freitas, T. C.; Mohrs, M.; Pearce, E. J.: IL-10R Blackade during Chronic Schistosomiasis Mansoni Results in the Loss of B cells from the Liver and Development of Severe Pulmonary Diseases. PLoS Pathogens 8, p. e1002490 (2012)
Journal Article
Huang, S. C.-C.; Freitas, T. C.; Amiel, E.; Everts, B.; Pearce, E. L.; Lok, J. B.; Pearce, E. J.: Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. PLoS Pathogens 8, p. e1002996 (2012)
Journal Article
Perona-Wright, G.; Kohlmeier, J. E.; Bassity, E.; Freitas, T. C.; Mohrs, K.; Cookenham, T.; Situ, H.; Pearce, E. J.; Woodland, D. L.; Mohrs, M.: Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in recall response. Proceedings of the National Academy of Sciences of the United States of America 109, pp. 18535 - 18540 (2012)
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