Publications of Marina A. Freudenberg

Minguet, S.; Dopfer, E. P.; Pollmer, C.; Freudenberg, M. A.; Galanos, C.; Reth, M.; Huber, M.; Schamel, W. W.: Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. European Journal of Immunology 38, pp. 2475 - 2487 (2008)

Siegemund, S.; Schütze, N.; Freudenberg, M. A.; Lutz, M. B.; Straubinger, R. K.; Alber, G.: Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis. Immunobiology 212, pp. 739 - 750 (2008)

Spiller, S.; Elson, G.; Ferstl, R.; Dreher, S.; Mueller, T.; Freudenberg, M.; Daubeuf, B.; Wagner, H.; Kirschning, C. J.: TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. The Journal of Experimental Medicine 205, pp. 1747 - 1754 (2008)

Fehrenbach, K.; Port, F.; Grochowy, G.; Kalis, C.; Bessler, W.; Galanos, C.; Krystal, G.; Freudenberg, M.; Huber, M.: Stimulation of mast cells via FcεR1 and TLR2: The type of ligand determines the outcome. Molecular Immunology 44, pp. 2087 - 2094 (2007)

Gumenscheimer, M.; Balkow, S.; Simon, M. M.; Jirillo, E.; Galanos, C.; Freudenberg, M. A.: Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections. Medical Microbiology and Immunology 196, pp. 79 - 88 (2007)

Heimesaat, M. M.; Fischer, A.; Jahn, H.-K.; Niebergall, J.; Freudenberg, M.; Blaut, M.; Liesenfeld, O.; Schumann, R. R.; Göbel, U. B.; Bereswill, S.: Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut 56, pp. 941 - 948 (2007)

Heimesaat, M.; Fischer, A.; Siegmund, B.; Kupz, A.; Niebergall, J.; Fuchs, D.; Jahn, H.-K.; Freudenberg, M.; Loddenkemper, C.; Batra, A. et al.; Lehr, H.-A.; Liesenfeld, O.; Blaut, M.; Göbel, U. B.; Schumann, R. R.; Bereswill, S.: Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4. PLoS One 2, pp. 1 - 7 (2007)

Hildenbrand, B.; Sauer, B.; Kalis, O.; Stoll, C.; Freudenberg, M. A.; Niedermann, G.; Giesler, J. M.; Jüttner, E.; Peters, J. H.; Häring, B. et al.; Leo, R.; Unger, C.; Azemar, M.: Immunotherapy of Patients With Hormone-Refractory Prostate Carcinoma Pre-Treated With Interferon-Gamma and Vaccinated With Autologous PSA-Peptide Loaded Dendritic Cells--A Pilot Study. The Prostrate 67, pp. 500 - 508 (2007)

Huber, M.; Kalis, C.; Keck, S.; Jiang, Z.; Georgel, P.; Du, X.; Shamel, L.; Sovath, S.; Mudd, S.; Beutler, B. et al.; Galanos, C.; Freudenberg, M. A.: R-form LPS, the master key to the activation of TLR4/MD-2-positive cells. European Journal of Immunology 36, pp. 701 - 711 (2006)

Liu, B.; Yang, Y.; Dai, J.; Medzhitov, R.; Freudenberg, M. A.; Zhang, P. L.; Li, Z.: TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-Like Autoimmune Disease. The Journal of Immunology 177, pp. 6880 - 6888 (2006)

Jian, Z.; Georgel, P.; Du, X.; Shamel, L.; Sovath, S.; Mudd, S.; Huber, M.; Kalis, C.; Keck, S.; Galanos, C. et al.; Freudenberg, M.; Beutler, B.: CD14 is required for MyD88-independent LPS signaling. Nature Immunology 6, pp. 565 - 570 (2005)

Kalis, C.; Gumenscheimer, M.; Freudenberg, N.; Tchaptchet, S.; Fejer, G.; Heit, A.; Akira, S.; Galanos, C.; Freudenberg, M.: Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes¹. The Journal of Immunology 174, pp. 4295 - 4300 (2005)

Schuetze, N.; Schoeneberger, S.; Mueller, U.; Freudenberg, M. A.; Alber, G.; Straubinger, R. K.: IL-12 family members: differential kinetics of their TLR-4 mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages. International Immunology 17, pp. 649 - 659 (2005)

Zhou, B.-R.; Gumenscheimer, M.; Freudenberg, M. A.; Galanos, C.: Lethal effect and apoptotic DNA fragmentation in response of D-GalN-treated mice to bacterial LPS can be suppressed by pre-exposure to minute amount of bacterial LPS: Dual role of TNF receptor 1. World Journal of Gastroenterology 11, pp. 3398 - 3404 (2005)

Antoniazi, S.; Price, H. P.; Kropf, P.; Freudenberg, M. A.; Galanos, C.; Smith, D. F.; Müller, I.: Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major. Infection and Immunity 72 (9), pp. 5168 - 5174 (2004)

Ehl, S.; Bischoff, R.; Ostler, T.; Vallbracht, S.; Schulte-Mönting, J.; Poltorak, A.; Freudenberg, M.: The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. European Journal of Immunology 34, pp. 1146 - 1153 (2004)

Kropf, P.; Freudenberg, M. A.; Modolell, M.; Price, H. P.; Herath, S.; Antoniazi, S.; Galanos, C.; Smith, D. F.; Müller, I.: Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major. Infection and Immunity 72, pp. 1920 - 1928 (2004)

Kropf, P.; Freudenberg, N.; Kalis, C.; Modolell, M.; Herath, S.; Galanos, C.; Freudenberg, M.; Müller, I.: Infection of C57BL/10ScCr and C57/BL10ScNCR mice with Leishmania major reveals a role for Toll-like receptor 4 in the control of parasite replication. Journal of Leukocyte Biology 76, pp. 48 - 57 (2004)

Echtenacher, B.; Urbaschek, R.; Weigl, K.; Freudenberg, M. A.; Männel, D. N.: Treatment of experimental sepsis-induced immunoparalysis with TNF. Immunobiology 208 (4), pp. 381 - 389 (2003)

Freudenberg, M. A.; Kalis, C.; Chvatchko, Y.; Merlin, T.; Gumenscheimer, M.; Galanos, C.: Role of interferons in LPS hypersensitivity. Journal of Endotoxin Research 9 (5), pp. 308 - 312 (2003)

Kalis, C.; Kanzler, B.; Lembo, A.; Poltorak, A.; Galanos, C.; Freudenberg, M. A.: Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. European Journal of Immunology 33 (3), pp. 798 - 805 (2003)

Lembo, A.; Kalis, C.; Kirschning, C. J.; Mitolo, V.; Jirillo, E.; Wagner, H.; Galanos, C.; Freudenberg, M. A.: Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice. Infection and Immunity 71 (10), pp. 6058 - 6062 (2003)

Schwamberger, G.; Hammerl, P.; Ferber, E.; Freudenberg, M.; Galanos, C.: TNF revisited: TNF-independent antitumor activity in sera of mice sensitized with Propionibacterium acnes and challenged with lipopolysaccharide. Journal of Leukocyte Biology 74 (6), pp. 1056 - 1063 (2003)

Zhou, B.-R.; Gumenscheimer, M.; Freudenberg, M.; Galanos, C.: A striking correlation between lethal activity and apoptotic DNA fragmentation of liver in response of D-galactosamine- sensitized mice to a non-lethal amount of lipopolysaccharide. Acta Pharmacologica Sinica 24 (3), pp. 193 - 198 (2003)

Brunialti, M. K. C.; Kallás, E. G.; Freudenberg, M.; Galanos, C.; Salomao, R.: Influence of EDTA and Heparin on Lipopolysaccharide Binding and Cell Activation, Evaluated at Single-Cell Level in Whole Blood. Cytometry 50 (1), pp. 14 - 18 (2002)

Freudenberg, M. A.; Merlin, T.; Kalis, C.; Chvatchko, Y.; Stübig, H.; Galanos, C.: Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative: Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling¹. The Journal of Immunology 169 (4), pp. 1665 - 1668 (2002)

Gaedicke, S.; Firat-Geier, E.; Constantiniu, O.; Lucchiari-Hartz, M.; Freudenberg, M.; Galanos, C.; Niedermann, G.: Antitumor Effect of the Human Immunodeficiency Virus Protease Inhibitor Ritonavir: Induction of Tumor-Cell Apoptosis Associated with Perturbation of Proteasomal Proteolysis. Cancer Research 62 (23), pp. 6901 - 6908 (2002)

Gumenscheimer, M.; Mitov, I.; Galanos, C.; Freudenberg, M. A.: Beneficial or Deleterious Effects of a Preexisting Hypersensitivity to Bacterial Components on the Course and Outcome of Infection. Infection and Immunity 70 (10), pp. 5596 - 5603 (2002)

Merlin, T.; Woelky-Bruggmann, R.; Fearns, C.; Freudenberg, M.; Landmann, R.: Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes. European Journal of Immunology 32 (3), pp. 761 - 772 (2002)

Salomao, R.; Brunialti, M. K. C.; Kallás, E. G.; Martins, P. S.; Rigato, O.; Freudenberg, M.: Lipopolysaccharide-cell interaction and induced cellular activation in whole blood of septic patients. Journal of Endotoxin Research 8 (5), pp. 371 - 379 (2002)