Publications

2017

Journal Article

Aktas, T.; Ilik, I. A.; Maticzka, D.; Bhardwaj, V.; Rodrigues , C. P.; Mittler, G.; Manke, T.; Backofen, R.; Akhtar, A.: DHX9 Suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 544, pp. 115 - 119 (2017)

MPG.PuRe

DOI

2016

Journal Article

Chatterjee, A.; Seyfferth, J.; Lucci, J.; Glisbach, R.; Preissl, S.; Böttinger, L.; Martensson, C. U.; Panhale, A.; Stehle, T.; Kretz, O. et al.; Sahyoun, A. H.; Avilov, S.; Eimer, S.; Hein, L.; Pfanner, N.; Becker, T.; Akhtar, A.: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell 167, pp. 722 - 738 (2016)

MPG.PuRe

DOI

Journal Article

Sheikh, B.N.; Bechtel-Walz, W.; Lucci, J.; Karpuik, O.; Hild, I.; Hartleben, B.; Vornweg, J.; Helmstädter, M.; Sahyoun, A.H.; Bhardwaj, V. et al.; Stehle, T.; Diehl, S.; Kretz, O.; Voss, A.K.; Thomas, T.; Manke, T.; Huber, T.B.; Akhtar, A.: MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35, pp. 2698 - 2710 (2016)

MPG.PuRe

DOI

Journal Article

Quinn, J. J.; Zhang, Q. C.; Georgiev, P.; Ilik, I. A.; Akhtar, A.; Chang, H. Y.: Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes and Development 30, pp. 191 - 207 (2016)

MPG.PuRe

DOI

Journal Article

Chlamydas, S.; Holz, H.; Samata, M.; Chelmicki, T.; Georgiev, P.; Pelechano, V.; Dündar, F.; Dasmeh, P.; Mittler, G.; Tavares Cadete, F. et al.; Ramirez, F.; Conrad, T.; Wei, W.; Raja, S.; Manke, T.; Luscombe, N. M.; Steinmetz, L. M.; Akhtar, A.: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural and Molecular Biology 23, pp. 580 - 589 (2016)

MPG.PuRe

DOI

2015

Journal Article

Ramirez, F.; Lingg, T.; Toscano, S.; Lam, K.-C.; Georgiev, P.; Chung, H.-R.; Lajoie, B. R.; de Wit, E.; Zhan, Y.; de laat, W. et al.; Dekker, J.; Manke, T.; Akhtar, A.: High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell 60, pp. 146 - 162 (2015)

MPG.PuRe

DOI

Journal Article

Meunier, S.; Shvedunova, M.; Van Nguyen, N.; Avila, l.; Vernos, I.; Akhtar, A.: An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications 6, 7889 (2015) (2015)

MPG.PuRe

DOI

Journal Article

Keller, C. I.; Akhtar, A.: The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development 31, pp. 1 - 11 (2015)

MPG.PuRe

DOI

2014

Journal Article

Furdas, S. D.; Hoffmann, I.; Robaa, D.; Herquel, B.; Malinka, W.; Świątek, P.; Akhtar, A.; Sippl, W.; Jung, M.: Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs). Medicinal Chemistry Communications 5, pp. 1856 - 1862 (2014)

MPG.PuRe

DOI

publisher-version

Journal Article

Bassett, A. R.; Akhtar, A.; Barlow, D. P.; Bird, A. P.; Brockdorff, N.; Duboule, D.; Ephrussi, A.; Ferguson-Smith, A. C.; Gingeras, T. R.; Haerty, W. et al.; Higgs, D. R.; Miska, E. A.; Ponting, C. P.: Considerations when investigating IncRNA function in vivo. eLife 3, e03058 (2014)

MPG.PuRe

DOI

Journal Article

Chelmicki, T.; Dündar, F.; Turley, M. J.; Khanam, T.; Aktas, T.; Ramírez, F.; Gendrel, A.-V.; Wright, P. R.; Videm, P.; Backofen, R. et al.; Heard, E.; Manke, T.; Akhtar, A.: MOF-associated complexes ensure stem cell identity and Xist repression. eLife 3, p. e02024 (2014)

MPG.PuRe

publisher-version

Journal Article

Dias, J.; Van Nguyen, N.; Georgiev, P.; Gaub, A.; Brettschneider, J.; Cusack, S.; Kadlec, J.; Akhtar, A.: Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes and Development 28, pp. 929 - 942 (2014)

MPG.PuRe

Journal Article

Quinn, J. J.; Ilik, I. A.; Qu, K.; Georgiev, P.; Chu, C.; Akhtar, A.; Chang, H. Y.: Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature biotechnology 32, pp. 933 - 940 (2014)

MPG.PuRe

2013

Journal Article

Ilik, I. A.; Quinn, J.; Georgiev, P.; Tavares-Cadete, F.; Maticzka, D.; Toscano, S.; Wan, Y.; Spitale, R. C.; Luscombe, N.; Backofen, R. et al.; Chang, H. Y.; Akhtar, A.: Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromsome Dosage Compensation in Drosophila. Molecular Cell 51, pp. 156 - 173 (2013)

MPG.PuRe

2012

Journal Article

Hallacli, E.; Lipp, M.; Georgiev, P.; Spielman, C.; Cusack, S.; Akhtar, A.; Kadlec, J.: Msl1-Mediated Dimerization of the Dosage Compensation Complex is Essential for Male X-Chromosome Regulation in Drosophila. Molecular Cell 48, pp. 587 - 600 (2012)

MPG.PuRe

Journal Article

Conrad, T.; Cavalli, F. M. G.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science 337, pp. 742 - 746 (2012)

MPG.PuRe

Journal Article

Lam, K. C.; Mühlpfordt, F.; Vaquerizas, J. M.; Raja, S. J.; Holz, H.; Luscombe, N. M.; Manke, T.; Akhtar, A.: The NSL Complex Regulates Housekeeping Genes in Drosophila. PLoS Genetics 8, p. e1002736 - e1002736 (2012)

MPG.PuRe

Journal Article

Conrad, T.; Cavalli, F. M. G.; Holz, H.; Hallacli, E.; Kind, J.; Ilik, I.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. Developmental Cell 22, pp. 610 - 624 (2012)

MPG.PuRe

Journal Article

Conrad, T.; Akhtar, A.: Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics 13, pp. 123 - 134 (2012)

MPG.PuRe

DOI

2011

Journal Article

Akhtar, A.; Fuchs, E.; Mitchison, T.; Shaw, R. J.; St Johnston, D.; Strasser, A.; Taylor, S.; Walczak, C.; Zerial, M.: A decade of molecular cell biology: achievements and challenges. Nature Reviews Molecular Cell Biology 12, pp. 669 - 674 (2011)

MPG.PuRe

DOI

Journal Article

Georgiev, P.; Chlamydas, S.; Akhtar, A.: Drosophila dosage compensation: males are from Mars, females are from Venus. Fly 5, pp. 147 - 154 (2011)

MPG.PuRe

DOI

Journal Article

Kadlec, J.; Hallacli, E.; Lipp, M.; Holz, H.; Sanchez-Weatherby, J.; Cusack, S.; Akhtar, A.: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Nature Structural & Molecular Biology 18, pp. 142 - 149 (2011)

MPG.PuRe

Journal Article

Arib, G.; Akhtar, A.: Multiple facets of nuclear periphery in gene expression control. Current Opinion in Cell Biology 23, pp. 346 - 353 (2011)

MPG.PuRe

2010

Journal Article

Andersen, D. S.; Raja, S. J.; Colombani, J.; Shaw, R. L.; Langton, P. F.; Akhtar, A.; Tapon, N.: Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. Molecular and Cellular Biology (Washington, DC) 30, pp. 4744 - 4755 (2010)

MPG.PuRe

DOI

Journal Article

Raja, S. J.; Charapitsa, I.; Conrad, T.; Vaquerizas, J. M.; Gebhardt, P.; Holz, H.; Kadlec, J.; Fraterman, S.; Luscombe, N. M.; Akhtar, A.: The Nonspecific Lethal Complex is a Transcriptional Regulator in Drosophila. Molecular Cell 38, pp. 827 - 841 (2010)

MPG.PuRe

Journal Article

Laverty, C.; Lucci, J.; Akhtar, A.: The MSL complex: X chromsome and beyond. Current Opinion in Genetics & Development 20, pp. 171 - 178 (2010)

MPG.PuRe

DOI

Journal Article

Vaquerizas, J. M.; Ritsuko, S.; Kind, J.; Miura, K.; Luscombe, N. M.; Akhtar, A.: Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome. PLoS Genetics 6, p. e1000846 - e1000846 (2010)

MPG.PuRe

2009

Journal Article

Hallacli, E.; Akhtar, A.: X chromosomal regulation in flies: when less is more. Chromosome Research, pp. 603 - 619 (2009)

MPG.PuRe

Journal Article

Ilik, I.; Akhtar, A.: roX RNAs. RNA Biology 6, pp. 113 - 121 (2009)

MPG.PuRe

Journal Article

Zhou, Y.; Schmitz, K.-M.; Mayer, C.; Yuan, X.; Akhtar, A.; Grummt, I.: Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nature Cell Biology 11, pp. 1010 - 1016 (2009)

MPG.PuRe

Publications of Asifa Akhtar

Journal Article (60)