Max Planck Institute of Immunobiology and Epigenetics

Publications of Asifa Akhtar

All genres

Journal Article (63)

2023

Journal Article

Guhathakurta, S.; Erdogdu, N. U.; Hoffmann, J. J.; Grzadzielewska, I.; Schendzielorz, A.; Seyfferth, J.; Mårtensson, C. U.; Corrado, M.; Karoutas, A.; Warscheid, B. et al.; Pfanner, N.; Becker, T.; Akhtar, A.: COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nature Metabolism (2023)

MPG.PuRe

publisher-version

Journal Article

Tsang, T. H.; Wiese, M.; Helmstädter, M.; Stehle, T.; Seyfferth, J.; Shvedunova, M.; Holz, H.; Walz, G.; Akhtar, A.: Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells. Science Advances 9, eadh5598 (2023)

MPG.PuRe

publisher-version

Journal Article

Iyer, S. S.; Sun, Y.; Seyfferth, J.; Manjunath, V.; Samata, M.; Alexiadis, A.; Kulkarni, T.; Gutierrez, N.; Georgiev, P.; Shvedunova, M. et al.; Akhtar, A.: The NSL complex is required for piRNA production from telomeric clusters. Life science alliance 6, e202302194 (2023)

MPG.PuRe

publisher-version

Journal Article

Akhtar, A.: Asifa Akhtar. Current Biology 33, pp. R286 - R287 (2023)

MPG.PuRe

2022

Journal Article

Shvedunova, M.; Akhtar, A.: Modulation of cellular processes by histone and non-histone protein acetylation. Nature Reviews Molecular Cell Biology 23, pp. 329 - 349 (2022)

MPG.PuRe

2021

Journal Article

Pessoa Rodrigues, C.; Chatterjee, A.; Wiese, M.; Stehle, T.; Szymanski, W. G.; Shvedunova, M.; Akhtar, A.: Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice. Nature Communications 12, 6212 (2021)

MPG.PuRe

publisher-version

Journal Article

Pessoa Rodrigues, C.; Akhtar, A.: Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science Advances 7 (32), eabi5987 (2021)

MPG.PuRe

publisher-version

Journal Article

Keller Valsecchi, C. I.; Marois, E.; Basilicata, M. F.; Georgiev, P.; Akhtar, A.: Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life science alliance 4, e202000996 (2021)

MPG.PuRe

publisher-version

Journal Article

Clapes, T.; Polyzou, A.; Prater, P.; Sagar; Morales-Hernández, A.; Ferrarini, M. G.; Kehrer, N.; Lefkopoulos, S.; Bergo, V.; Hummel, B. et al.; Obier, N.; Maticzka, D.; Bridgeman, A.; Herman, J. S.; Ilik, I.; Klaeylé, L.; Rehwinkel, J.; McKinney-Freeman, S.; Backofen, R.; Akhtar, A.; Cabezas-Wallscheid, N.; Sawarkar, R.; Rebollo, R.; Grün, D.; Trompouki, E.: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology 23, pp. 704 - 717 (2021)

MPG.PuRe

publisher-version

publisher-version

Journal Article

Karoutas, A.; Akhtar, A.: Functional mechanisms and abnormalities of the nuclear lamina. Nature Cell Biology 23, pp. 116 - 126 (2021)

MPG.PuRe

2020

Journal Article

Keller Valsecchi, C. I.; Basilicata, M. F.; Georgiev, P.; Gaub, A.; Seyfferth, J.; Kulkarni, T.; Panhale, A.; Semplicio, G.; Manjunath, V.; Holz, H. et al.; Dasmeh, P.; Akhtar, A.: RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, pp. 137 - 142 (2020)

MPG.PuRe

Journal Article

Pessoa Rodrigues, C.; Shvedunova, M.; Akhtar, A.: Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics 37, pp. 125 - 142 (2020)

MPG.PuRe

publisher-version

Journal Article

Samata, M.; Alexia, A.; Richard, G.; Georgiev, P.; Nuebler, J.; Kulkarni, T.; Renschler, G. V.; Basilicata, M. F.; Zenk, F. L.; Shvedunova, M. et al.; Semplicio, G.; Mirny, L.; Iovino, N.; Akhtar, A.: Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell 182, pp. 127 - 144 (2020)

MPG.PuRe

Journal Article

Sheikh, B. N.; Guhathakurta, S.; Tsang, T. H.; Schwabenland, M.; Renschler, G. V.; Herquel, B.; Bhardwaj, V.; Holz, H.; Stehle, T.; Bondareva, O. et al.; Aizarni, N.; Mossad, O.; Kretz, O.; Reichardt, W.; Chatterjee, A.; Braun, L. J.; Thevenon, J.; Sartelet, H.; Blank, T.; Grün, D.; von Elverfeldt, D.; Huber, T. B.; Vestweber, D.; Avilov, S.; Prinz, M.; Büscher, J. M.; Akhtar, A.: Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology 22, pp. 828 - 841 (2020)

MPG.PuRe

Journal Article

Ilik, I. A.; Aktas, T.; Maticzka, D.; Backofen, R.; Akhtar, A.: FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research 48, p. e15 (2020)

MPG.PuRe

Journal Article

Estrada Mallarino, L.; Engel, C.; Ilik, I. A.; Maticzka, D.; Heyl, F.; Müller, B.; Yakulov, T. A.; Dengjel, J.; Backofen, R.; Akhtar, A. et al.; Walz, G.: Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Scientific Reports 10, pp. 1 - 14 (2020)

MPG.PuRe

Journal Article

Gaub, A.; Sheikh, B. N.; Basilicata, M. F.; Vincent, M.; Nizon, M.; Colson, C.; Bird, M. J.; Bradner, J. E.; Thevenon, J.; Boutros, M. et al.; Akhtar, A.: Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications 11, p. 2243 (2020)

MPG.PuRe

Journal Article

Rodrigues, C. P.; Herman, J. S.; Herquel, B.; Velsecchi Keller, C. I.; Stehle, T.; Grün, D.; Akhtar, A.: Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances 6, p. eaaz4815 (2020)

MPG.PuRe

2019

Journal Article

Sheikh, B. N.; Bondareva, O.; Guhathakurta, S.; Tsang, T. H.; Sikora, K.; Aizarani, N.; Sagar, S.; Holz, H.; Grün, D.; Hein, L. et al.; Akhtar, A.: Systematic Identification of Cell-Cell Communication Networks in the Developing Brain. iScience 21, pp. 273 - 287 (2019)

MPG.PuRe

Journal Article

Renschler, G.; Gautier, R.; Claudia, V.; Toscano, S.; Arrigoni, L.; Ramírez, F.; Akhtar, A.: Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, pp. 1591 - 1612 (2019)

MPG.PuRe

Journal Article

Karoutas, A.; Szymanski, W. G.; Rausch, T.; Guhathakurta, S.; Rog-Zielinska, E. A.; Peyronnet, R.; Seyfferth, J.; Chen, H.-R.; de Leeuw, R.; Herquel, B. et al.; Kimura, H.; Mittler, G.; Kohl, P.; Medalia, O.; Korbel, J. O.; Akhtar, A.: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology 21, pp. 1248 - 1260 (2019)

MPG.PuRe

Journal Article

Bhardwaj, V.; Semplicio, G.; Erdogdu, N. U.; Manke, T.; Akhtar, A.: MapCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications 10, p. 3219 (2019)

MPG.PuRe

Journal Article

Panhale, A.; Richter , F. M.; Ramírez, F.; Shvedunova, M.; Manke, T.; Mittler, G.; Akhtar, A.: CAPRI enables comparison of evolutionary conserved RNA interacting regions. Nature Communications 10, 2682 (2019) (2019)

MPG.PuRe

Journal Article

Sheikh, B.; Guhathakurta, S.; Akhtar, A.: The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. EMBO Reports 20, p. e47360 (2019)

MPG.PuRe

Journal Article

Lam, K.-C.; Chung, H.-R.; Semplicio, G.; Iyer, S. S.; Gaub, A.; Bhardwaj, V.; Holz, H.; Georgiev, P.; Akhtar, A.: The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, pp. 453 - 465 (2019)

MPG.PuRe

Journal Article

Sheikh, B.; Akhtar, A.: Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics 20, pp. 7 - 23 (2019)

MPG.PuRe

2018

Journal Article

Basilicata, M. F.; Bruel, A.-L.; Semplicio, G.; Keller Valsecchi, C. I.; Aktaş, T.; Duffourd, Y.; Rumpf, T.; Morton, J.; Bache, I.; Szymanski, W. G. et al.; Gilissen, C.; Vanakker, O.; Õunap, K.; Mittler, G.; van der Burgt, I.; Chehadeh, S. E.; Cho, M. T.; Pfundt, R.; Tan, T. Y.; Kirchhoff, M.; Menten, B.; Vergult, S.; Lindstrom, K.; Reis, A.; Johnson, D. S.; Fryer, A.; McKay, V.; Study, D.; Fisher, R. B.; Thauvin-Robinet, C.; Francis, D.; Roscioli, T.; Pajusalu, S.; Radtke, K.; Ganesh, J.; Brunner, H. G.; Wilson, M.; Faivre, L.; Kalscheuer, V. M.; Thevenon , J.; Akhtar, A.: De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nature Genetics, pp. 1442 - 1451 (2018)

MPG.PuRe

Journal Article

Akhtar, A.: Finding your way through the science maze. Nature Genetics 20, p. 1000 (2018)

MPG.PuRe

Journal Article

Samata, M.; Akhtar, A.: Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry 87, pp. 323 - 350 (2018)

MPG.PuRe

Journal Article

Ramirez, F.; Bhardwaj, V.; Arrigoni, L.; Lam, K. C.; Grüning, B. A.; Villaveces, J.; Habermann, B.; Akhtar, A.; Manke, T.: High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications 9, p. 189 (2018)

MPG.PuRe