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Journal Article (50)

  1. 2020
    Journal Article
    Samata, M.; Alexia, A.; Richard, G.; Georgiev, P.; Nuebler, J.; Kulkarni, T.; Renschler, G. V.; Basilicata, M. F.; Zenk, F. L.; Shvedunova, M. et al.; Semplicio, G.; Mirny, L.; Iovino, N.; Akhtar, A.: Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell 182, pp. 1 - 18 (2020)
  2. Journal Article
    Sheikh, B. N.; Guhathakurta, S.; Tsang, T. H.; Schwabenland, M.; Renschler, G. V.; Herquel, B.; Bhardwaj, V.; Holz, H.; Stehle, T.; Bondareva, O. et al.; Aizarni, N.; Mossad, O.; Kretz, O.; Reichardt, W.; Chatterjee, A.; Braun, L. J.; Thevenon, J.; Sartelet, H.; Blank, T.; Grün, D.; von Elverfeldt, D.; Huber, T. B.; Vestweber, D.; Avilov, S.; Prinz, M.; Büscher, J. M.; Akhtar, A.: Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology (2020)
  3. Journal Article
    Ilik, I. A.; Aktas, T.; Maticzka, D.; Backofen, R.; Akhtar, A.: FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research 48, p. e15 (2020)
  4. Journal Article
    Gaub, A.; Sheikh, B. N.; Basilicata, M. F.; Vincent, M.; Nizon, M.; Colson, C.; Bird, M. J.; Bradner, J. E.; Thevenon, J.; Boutros, M. et al.; Akhtar, A.: Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications 11, p. 2243 (2020)
  5. Journal Article
    Rodrigues, C. P.; Herman, J. S.; Herquel, B.; Velsecchi Keller, C. I.; Stehle, T.; Grün, D.; Akhtar, A.: Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances 6, p. eaaz4815 (2020)
  6. 2019
    Journal Article
    Sheikh, B. N.; Bondareva, O.; Guhathakurta, S.; Tsang, T. H.; Sikora, K.; Aizarani, N.; Sagar, S.; Holz, H.; Grün, D.; Hein, L. et al.; Akhtar, A.: Systematic Identification of Cell-Cell Communication Networks in the Developing Brain. iScience 21, pp. 273 - 287 (2019)
  7. Journal Article
    Karoutas, A.; Szymanski, W.; Rausch, T.; Guhathakurta, S.; Rog-Zielinska, E. A.; Peyronnet, R.; Seyfferth, J.; Chen, H.-R.; de Leeuw, R.; Herquel, B. et al.; Kimura, H.; Mittler, G.; Kohl, P.; Medalia, O.; Korbel, J. O.; Akhtar, A.: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology 21, pp. 1248 - 1260 (2019)
  8. Journal Article
    Bhardwaj, V.; Semplicio, G.; Erdogdu, N. U.; Manke, T.; Akhtar, A.: MapCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications 10, p. 3219 (2019)
  9. Journal Article
    Lam, K.-C.; Chung, H.-R.; Semplicio, G.; Iyer, S. S.; Gaub, A.; Bhardwaj, V.; Holz, H.; Georgiev, P.; Akhtar, A.: The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, pp. 453 - 465 (2019)
  10. Journal Article
    Panhale, A.; Richter , F. M.; Ramírez, F.; Shvedunova, M.; Manke, T.; Mittler, G.; Akhtar, A.: CAPRI enables comparison of evolutionary conserved RNA interacting regions. Nature Communications 10, p. 2682 (2019)
  11. Journal Article
    Renschler, G.; Richard, G.; Keller Valsecchi, C. I.; Toscano, S.; Arrigoni, L.; Ramírez, F.; Akhtar, A.: Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, pp. 1591 - 1612 (2019)
  12. Journal Article
    Sheikh, B.; Akhtar, A.: Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics 20, pp. 7 - 23 (2019)
  13. Journal Article
    Sheikh, B.; Guhathakurta, S.; Akhtar, A.: The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. EMBO Reports, p. e47360 (2019)
  14. 2018
    Journal Article
    Basilicata, M. F.; Bruel, A.-L.; Semplicio, G.; Keller Valsecchi, C. I.; Aktaş, T.; Duffourd, Y.; Rumpf, T.; Morton, J.; Bache, I.; Szymanski, W. G. et al.; Gilissen, C.; Vanakker, O.; Õunap, K.; Mittler, G.; van der Burgt, I.; Chehadeh, S. E.; Cho, M. T.; Pfundt, R.; Tan, T. Y.; Kirchhoff, M.; Menten, B.; Vergult, S.; Lindstrom, K.; Reis, A.; Johnson, D. S.; Fryer, A.; McKay, V.; Study, D.; Fisher, R. B.; Thauvin-Robinet, C.; Francis, D.; Roscioli, T.; Pajusalu, S.; Radtke, K.; Ganesh, J.; Brunner, H. G.; Wilson, M.; Faivre, L.; Kalscheuer, V. M.; Thevenon , J.; Akhtar, A.: De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nature Genetics, pp. 1442 - 1451 (2018)
  15. Journal Article
    Samata, M.; Akhtar, A.: Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry, pp. 34.1 - 34.28 (2018)
  16. Journal Article
    Akhtar, A.: Finding your way through the science maze. Nature Genetics 9 (2018)
  17. Journal Article
    Maticzka, D.; Ilik, I. A.; Aktas, T.; Backofen, R.; Akhtar, A.: uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins. Nature Communications 9, p. 1142 (2018)
  18. Journal Article
    Ramirez, F.; Bhardwaj, V.; Arrigoni, L.; Lam, K. C.; Grüning, B. A.; Villaveces, J.; Habermann, B.; Akhtar, A.; Manke, T.: High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications 9, p. 189 (2018)
  19. Journal Article
    Valsecchi Keller, C. I.; Basilicata , M. F.; Semplicio, G.; Georgiev, P.; Gutierrez, N. M.; Akhtar, A.: Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nature Communications 9, p. 3926 (2018)
  20. 2017
    Journal Article
    Ilik, I. A.; Maticzka, D.; Georgiev, P.; Gutierrez, N. M.; Backofen, R.; Akhtar, A.: A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes and Development, pp. 1973 - 1987 (2017)
  21. Journal Article
    Aktas, T.; Ilik, I. A.; Maticzka, D.; Bhardwaj, V.; Rodrigues , C. P.; Mittler, G.; Manke, T.; Backofen, R.; Akhtar, A.: DHX9 Suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 544, pp. 115 - 119 (2017)
  22. 2016
    Journal Article
    Chatterjee, A.; Seyfferth, J.; Lucci, J.; Glisbach, R.; Preissl, S.; Böttinger, L.; Martensson, C. U.; Panhale, A.; Stehle, T.; Kretz, O. et al.; Sahyoun, A. H.; Avilov, S.; Eimer, S.; Hein, L.; Pfanner, N.; Becker, T.; Akhtar, A.: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell 167, pp. 722 - 738 (2016)
  23. Journal Article
    Sheikh, B.N.; Bechtel-Walz, W.; Lucci, J.; Karpuik, O.; Hild, I.; Hartleben, B.; Vornweg, J.; Helmstädter, M.; Sahyoun, A.H.; Bhardwaj, V. et al.; Stehle, T.; Diehl, S.; Kretz, O.; Voss, A.K.; Thomas, T.; Manke, T.; Huber, T.B.; Akhtar, A.: MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35, pp. 2698 - 2710 (2016)
  24. Journal Article
    Quinn, J. J.; Zhang, Q. C.; Georgiev, P.; Ilik, I. A.; Akhtar, A.; Chang, H. Y.: Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes and Development 30, pp. 191 - 207 (2016)
  25. Journal Article
    Chlamydas, S.; Holz, H.; Samata, M.; Chelmicki, T.; Georgiev, P.; Pelechano, V.; Dündar, F.; Dasmeh, P.; Mittler, G.; Tavares Cadete, F. et al.; Ramirez, F.; Conrad, T.; Wei, W.; Raja, S.; Manke, T.; Luscombe, N. M.; Steinmetz, L. M.; Akhtar, A.: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural and Molecular Biology 23, pp. 580 - 589 (2016)
  26. 2015
    Journal Article
    Ramirez, F.; Lingg, T.; Toscano, S.; Lam, K.-C.; Georgiev, P.; Chung, H.-R.; Lajoie, B. R.; de Wit, E.; Zhan, Y.; de laat, W. et al.; Dekker, J.; Manke, T.; Akhtar, A.: High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell 60, pp. 146 - 162 (2015)
  27. Journal Article
    Meunier, S.; Shvedunova, M.; Van Nguyen, N.; Avila, l.; Vernos, I.; Akhtar, A.: An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications 6, p. 7889 (2015)
  28. Journal Article
    Keller, C. I.; Akhtar, A.: The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development 31, pp. 1 - 11 (2015)
  29. 2014
    Journal Article
    Bassett, A. R.; Akhtar, A.; Barlow, D. P.; Bird, A. P.; Brockdorff, N.; Duboule, D.; Ephrussi, A.; Ferguson-Smith, A. C.; Gingeras, T. R.; Haerty, W. et al.; Higgs, D. R.; Miska, E. A.; Ponting, C. P.: Considerations when investigating IncRNA function in vivo. eLife 3, p. e03058 (2014)
  30. Journal Article
    Chelmicki, T.; Dündar, F.; Turley, M. J.; Khanam, T.; Aktas, T.; Ramírez, F.; Gendrel, A.-V.; Wright, P. R.; Videm, P.; Backofen, R. et al.; Heard, E.; Manke, T.; Akhtar, A.: MOF-associated complexes ensure stem cell identity and Xist repression. eLife 3, p. e02024 (2014)
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