Max Planck Institute of Immunobiology and Epigenetics

Publications

Publications

Lab Jenuwein

2025

Fuhrmann, T.; Shukeir, N.; Ching, R. W.; Erikson, G.; Dou, Y.; Sawitzki, Z.; Onishi-Seebacher, M.; Galan, C.; Jenuwein, T.: The isoflavone genistein selectively stimulates major satellite repeat transcription in mouse heterochromatin. Epigenetics & Chromatin 18, 58 (2025)

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publisher-version

Ching, R. W.; Świst-Rosowska, K. M.; Erikson, G.; Koschorz, B.; Engist, B.; Jenuwein, T.: Forced expression of MSR repeat transcripts above a threshold limit breaks heterochromatin organisation. Nature Communications 16, 6420 (2025)

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publisher-version

2024

Pantier, R.; Brown, M.; Han, S.; Paton, K.; Meek, S.; Montavon, T.; Shukeir, N.; McHugh, T.; Kelly, D. A.; Hochepied, T. et al.; Libert, C.; Jenuwein, T.; Burdon, T.; Bird, A.: MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation. Nature Communications 15, 3880 (2024)

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publisher-version

2023

Djeghloul, D.; Dimond, A.; Cheriyamkunnel, S.; Kramer, H.; Patel, B.; Brown, K.; Montoya, A.; Whilding, C.; Wang, Y.-F.; Futschik, M. E. et al.; Veland, N.; Montavon, T.; Jenuwein, T.; Merkenschlager, M.; Fisher, A. G.: Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis. Nature Structural and Molecular Biology 30, pp. 489 - 501 (2023)

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publisher-version

2022

Baixauli, F.; Piletic, K.; Puleston, D. J.; Villa, M.; Field, C. S.; Flachsmann, L. J.; Quintana, A.; Rana, N.; Edwards-Hicks, J.; Matsushita, M. et al.; Stanczak, M. A.; Grzes, K. M.; Kabat, A. M.; Fabri, M.; Caputa, G.; Kelly, B.; Corrado, M.; Musa, Y.; Duda, K. J.; Mittler, G.; O'Sullivan, D.; Sesaki, H.; Jenuwein, T.; Büscher, J. M.; Pearce, E. J.; Sanin, D. E.; Pearce, E. L.: An LKB1-mitochondria axis controls T_H17 effector function. Nature 610, pp. 555 - 561 (2022)

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publisher-version

2021

Montavon, T.; Shukeir, N.; Erikson, G.; Engist, B.; Onishi-Seebacher, M.; Ryan, D.; Musa, Y.; Mittler, G.; Meyer, A. G.; Genoud, C. et al.; Jenuwein, T.: Complete loss of H3K9 methylation dissolves mouse heterochromatin organization. Nature Communications 12, 4359 (2021)

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publisher-version

Onishi-Seebacher, M.; Erikson, G.; Sawitzki, Z.; Ryan, D.; Greve, G.; Lübbert, M.; Jenuwein, T.: Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia. BMC Medical Genomics 14, 166 (2021)

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publisher-version

Duda, K. J.; Ching, R. W.; Jerabek, L.; Shukeir, N.; Erikson, G.; Engist, B.; Onishi-Seebacher, M.; Perrera, V.; Richter, F.; Mittler, G. et al.; Fritz, K.; Helm, M.; Knuckles, P.; Bühler, M.; Jenuwein, T.: m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin. Nucleic Acids Research (London) 49, pp. 5568 - 5587 (2021)

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publisher-version

2020

Lefkopoulos, S.; Polyzou, A.; Derecka, M.; Bergo, V.; Clapes, T.; Cauchy, P.; Jerez-Longres, C.; Onishi-Seebacher, M.; Yin, N.; Martagon-Calderón, N.-A. et al.; Potts, K. S.; Klaeylé, L.; Liu, F.; Bowman, T. V.; Jenuwein, T.; Mione, M. C.; Trompouki, E.: Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the emergence of Hematopoietic Stem and Progenitor Cells. Immunity 53, pp. 934 - 951 (2020)

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Burton, A.; Brochard, V.; Galan, C.; Ruiz-Morales, E. R.; Rovira, Q.; Rodriguez-Terrones, D.; Kruse, K.; Le Gras, S.; Udayakumar, V. S.; Chin, H. G. et al.; Eid, A.; Liu, X.; Wang, C.; Gao, S.; Pradhan, S.; Vaquerizas, J. M.; Beaujean, N.; Jenuwein, T.; Torres-Padilla, M.-E.: Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3. Nature Cell Biology 22, pp. 767 - 778 (2020)

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Healton, S. E.; Pinto, H. D.; Mishra, L. N.; Hamilton, G. A.; Wheat, J. C.; Swist-Rosowska, K.; Nicholas, S.; Dou, Y.; Steidl, U.; Jenuwein, T. et al.; Gamble, M. J.; Skoultchi, A. I.: H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction. Proceedings of the National Academy of Sciences of the United States of America 117, pp. 14251 - 14258 (2020)

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Walther, M.; Schrahn, S.; Krauss, V.; Lein, S.; Kessler, J.; Jenuwein, T.; Reuter, G.: Heterochromatin formation in Drosophila requires genome-wide histone deacetylation in cleavage chromatin before mid-blastula transition in early embryogenesis. Chromosoma: Biology of the Nucleus 129, pp. 83 - 98 (2020)

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2019

Qiu, J.; Villa, M.; Sanin, P. D. E.; Buck, M. D.; O’Sullivan, D.; Ching, R. W.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Jonathan, D. C.; Kyle, R. L.; Bakker, N. V. T.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, pp. 2063 - 2074 (2019)

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Nicetto, D.; Donahue, G.; Jain, T.; Peng, T.; Sidoli, S.; Sheng, L.; Montavon, T.; Becker, J. S.; Grindheim, J. M.; Blahnik, K. et al.; Garcia, B. A.; Tan, K.; Bonasio, R.; Jenuwein, T.; Zaret, K. S.: H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification. Science 363, pp. 294 - 297 (2019)

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2018

Santos-Barriopedro, I.; Bosch-Presegue, L.; Marazuela-Duque, A.; de la Torre, C.; Colomer, C.; Vazquez, B. N.; Fuhrmann, T.; Martinez-Pastor, B.; Lu, W.; Braun, T. et al.; Bober, E.; Jenuwein, T.; Serrano, L.; Esteller, M.; Chen, Z.; Barcelo-Batllori, S.; Mostoslavsky, R.; Espinosa, L.; Vaquero, A.: SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-kappa B pathway. Nature Communications 9, 101 (2018) (2018)

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2017

Costantino, S.; Paneni, F.; Virdis, A.; Hussain, S.; Mohammed, S. A.; Capretti, G.; Akhmedov, A.; Dalgaard, K.; Chiandotto, S.; Pospisilik, J. A. et al.; Jenuwein, T.; Giorgio, M.; Volpe, M.; Taddei, S.; Lüscher, T. F.; Cosentino, F.: Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66^Shc transcription and vascular oxidative stress in obesity. European Heart Journal 40, pp. 383 - 391 (2017)

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Camacho, O. V.; Galan, C.; Swist-Rosowska, K.; Ching, R.; Gamalinda, M.; Karabiber, F.; De la Rosa-Velazquez, I. A.; Engist, B.; Koschorz, B.; Shukeir, N. et al.; Onishi-Seebacher, M.; van de Nobelen, S.; Jenuwein, T.: Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome assocation and RNA:DNA hybrid formation. eLife, p. e25293 (2017)

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Fan, Z.; Li, L.; Li, M.; Zhang, X.; Hao, C.; Yu, L.; Zeng, S.; Xu, H.; Fang, M.; Shen, A. et al.; Jenuwein, T.; Xu, Y.: The Histone Methyltransferase Suv39h2 Contributes to Nonalcoholic Steatohepatitis in Mice. Hepatology 65, pp. 1904 - 1919 (2017)

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Nguyen, D. T.; Voon, H. P. J.; Xella, B.; Scott, C.; Clynes, D.; Babbs, C.; Ayyub, H.; Kerry, J.; Sharpe, J. A.; Sloane‐Stanley, J. A. et al.; Butler, S.; Fisher, C. A.; Gray, N. E.; Jenuwein, T.; Higgs, D. R.; Gibbons, R. J.: The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats. EMBO Reports 18, pp. 914 - 928 (2017)

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Yang, G.; Weng, X.; Zhao, Y.; Zhang, X.; Hu, Y.; Dai, X.; Liang, P.; Wang, P.; Ma, L.; Sun, X. et al.; Hou, L.; Xu, H.; Fang, M.; Li, Y.; Jenuwein, T.; Xu, Y.; Sun, A.: The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction. Nature Communications 8, 14941 (2017) (2017)

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2016

Allis, C. D.; Jenuwein, T.: The molecular hallmarks of epigenetic control. Nature Reviews Genetics 17, pp. 487 - 500 (2016)

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Hiragami-Hamada, K.; Sörös, S.; Nikolov, M.; Wilkins, B.; Kreuz, S.; Chen, C.; De La Rosa-Velazquez, I. A.; Zenn, H. M.; Kost, N.; Pohl, W. et al.; Chernev, A.; Schwarzer, D.; Jenuwein, T.; Lorincz, M.; Zimmermann, B.; Walla, P. J.; Neumann, H.; Baubec, T.; Urlaub, H.; Fischle, W.: Dynamic and flexible H3K9me3 bridging via HP1beta dimerization establishes a plastic state of condensed chromatin. Nature Communications 7, 11310 (2016) (2016)

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Dalgaard, K.; Landgraf, K.; Heyne, S.; Lempradl, A.; Longinotto, J.; Gossens, K.; Ruf, M.; Orthofer, M.; Strogantsev, R.; Selvaraj, M. et al.; Lu, T. T.-H.; Casas, E.; Teperino, R.; Surani, M. A.; Zvetkova, I.; Rimmington, D.; Tung, Y.C. L.; Lam, B.; Larder, R.; Yeo, G. S.H.; O’Rahilly, S.; Vavouri, T.; Whitelaw, E.; Penninger, J. M.; Jenuwein, T.; Cheung, C.-L.; Ferguson-Smith, A. C.; Coll, A. P.; Körner, A.; Pospisilik, J. A.: Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell 164, pp. 353 - 364 (2016)

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Foti, R.; Gnan, S.; Cornacchia, D.; Dileep, V.; Bulut-Karslioglu, A.; Diehl, S.; Buness, A.; Klein, F. A.; Huber, W.; Johnstone, E. et al.; Loos, R.; Bertone, P.; Gilbert, D. M.; Manke, T.; Jenuwein, T.; Buonomo, S. C.B.: Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program. Molecular Cell 61, pp. 260 - 273 (2016)

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2015

Voon, H. P.J.; Hughes, J. R.; Rode, C.; De La Rosa-Velázquez, I. A.; Jenuwein, T.; Feil, R.; Higgs, D. R.; Gibbons, R. J.: ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes. Cell Reports 11, pp. 405 - 418 (2015)

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2014

Sone, K.; Piao, L.; Nakakido, M.; Ueda, K.; Jenuwein, T.; Nakamura, Y.; Hamamoto, R.: Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nature Communications 5, 5691 (2014), p. 5691 (2014)

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Bulut-Karslioglu, A.; De la Rosa-Velazquez, I. A.; Ramirez, F.; Barenboim, M.; Onishi-Seebacher, M.; Arand, J.; Galán, C.; Winter, G. E.; Engist, B.; Gerle, B. et al.; O'Sullivan, R. J.; Martens, J. H. A.; Walter, J.; Manke, T.; Lachner, M.; Jenuwein, T.: Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells. Molecular Cell 55, pp. 277 - 290 (2014)

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2013

Millanes-Romero, A.; Herranz, N.; Perrera, V.; Iturbide, A.; Loubat-Casanovas, J.; Jesús, G.; Jenuwein, T.; García de Herreros, A.; Peiró, S.: Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition. Molecular Cell 52, pp. 746 - 757 (2013)

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2012

Bulut-Karslioglu, A.; Perrera, V.; Scaranaro, M.; de la Rosa-Velazquez, I. A.; van de Nobelen, S.; Shukeir, N.; Popow, J.; Gerle, B.; Opravil, S.; Pagani, M. et al.; Meidhof, S.; Brabletz, T.; Manke, T.; Lachner, M.; Jenuwein, T.: A transcription factor-based mechanism for mouse heterochromatin formation. Nature Structural and Molecular Biology 19, pp. 1023 - 1030 (2012)

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Pinheiro, I.; Margueron, R.; Shukeir, N.; Eisold, M.; Fritzsch, C.; Richter, F. M.; Mittler, G.; Genoud, C.; Goyama, S.; Kurokawa, M. et al.; Son, J.; Reinberg, D.; Lachner, M.; Jenuwein, T.: Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity. Cell 150, pp. 948 - 960 (2012)

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Arand, J.; Spieler, D.; Karius, T.; Branco, M. R.; Meilinger, D.; Meissner, A.; Jenuwein, T.; Xu, G.; Leonhardt, H.; Wolf, V. et al.; Walter, J.: In vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases. PLoS Genetics 8, e1002750 (2012)

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2011

Jin, C.; Li, J.; Green, C. D.; Yu, X.; Tang, X.; Han, D.; Xian, B.; Wang, D.; Huang, X.; Cao, X. et al.; Yan, Z.; Hou, L.; Liu, J.; Shukeir, N.; Khaitovich, P.; Chen, C. D.; Zhang, H.; Jenuwein, T.; Han, J.-d. J.: Histone Demethylase UTX-1 Regulates C.elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway. Cell Metabolism 14, pp. 161 - 172 (2011)

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Lu, F.; Cui, X.; Zhang, S.; Jenuwein, T.; Cao, X.: Arabidopsis REF6 is a histone H3 lysine 27 demethylase. Nature Genetics 43, pp. 715 - 719 (2011)

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2010

Fodor, B. D.; Shukeir, N.; Reuter, G.; Jenuwein, T.: Mammalian Su(var) Genes in Chromatin Control. Annual Review of Cell and Developmental Biology 26, pp. 471 - 501 (2010)

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Feng, W.; Yonezawa, M.; Ye, J.; Jenuwein, T.; Grummt, I.: PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nature Structural and Molecular Biology 17, pp. 445 - 450 (2010)

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Huang, J.; Dorsey, J.; Schikov, S.; Zhang, X.; Jenuwein, T.; Reinberg, D.; Berger, S.: G9a and Glp Methylate lysine 373 in the Tumor Suppressor p53. The Journal of Biological Chemistry 285, pp. 9636 - 9641 (2010)

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Reimann, M.; Lee, S.; Loddenkemper, C.; Dörr, J. R.; Tabor, V.; Aichele, P.; Stein, H.; Dörken, B.; Jenuwein, T.; Schmitt, C. A.: Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphoma-genesis via Suv39h1-Dependent Senescence. Cancer Cell 17, pp. 262 - 272 (2010)

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Chen, L.; Li, Z.; Zwolinska, A. K.; Smith, M. A.; Cross, B.; Koomen, J.; Yuan, Z.-M.; Jenuwein, T.; Marine, J.-C.; Wright, K. L. et al.; Chen, J.: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. The EMBO Journal 29, pp. 2538 - 2552 (2010)

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2009

Trojer, P.; Zhang, J.; Schmidt, A.; Zheng, H.; Jenuwein, T.; Reinberg, D.: Dynamics Histone H1 Isotype 4 Methylation and Demthylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji domain-containing JMJD2/KDM4 Proteins. The Journal of Biological Chemistry 284, pp. 8395 - 8405 (2009)

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Savarese, F.; Dávila, A.; Nechanitzky, R.; De la Rosa-Velazquez, I. A.; Pereira, C. F.; Engelke, R.; Takahashi, K.; Jenuwein, T.; Kohwi-Shigematsue, T.; Fisher, A. et al.; Grosschedl, R.: Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes and Development 23, pp. 2625 - 2638 (2009)

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2008

Pauler, F. M.; Sloane, M. A.; Huang, R.; Regha, K.; Koerner, M. V.; Tamir, I.; Sommer, A.; Aszodi, A.; Jenuwein, T.: H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Research 19, pp. 221 - 233 (2008)

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Pannetier, M.; Julien, E.; Schotta, G.; Mathieu, T.; Sardet, C.; Jenuwein, T.; Feil, R.: PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse. EMBO Reports 9, pp. 998 - 1005 (2008)

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Schotta, G.; Sengupta, R.; Kubicek, S.; Malin, S.; Kauer, M.; Callén, E.; Celeste, A.; Pagani, M.; Opravil, S.; De La Rosa-Velazquez, I. A. et al.; Espejo, A.; Bedford, M. T.; Nussenzweig, A.; Busslinger, M.; Jenuwein, T.: A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development 22, pp. 2048 - 2061 (2008)

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2007

Wissmann, M.; Yin, N.; Müller, J. M.; Greshik, H.; Fodor, B. D.; Jenuwein, T.; Vogler, C.; Schneider, R.; Günther, T.; Buettner, R. et al.; Metzger, E.; Schüle, R.: Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nature Cell Biology 9, pp. 347 - 353 (2007)

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