
Publikationen
Labor Boehm
2025
Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells. Nature Communications 16, 6503 (2025)
Lamprey FOXN1 rescues the block of thymic epithelial cell development in the mouse Foxn1-deficient thymic rudiment. Proceedings of the National Academy of Sciences of the United States of America 122, e2520664122 (2025)
Developmental trajectory and evolutionary origin of thymic mimetic cells. Nature 643, S. 1066 - 1075 (2025)
2024
Understanding vertebrate immunity through comparative immunology. Nature Reviews Immunology 25, S. 141 - 152 (2024)
Probing TCR Specificity Using Artificial In Vivo Diversification of CDR3 Regions. European Journal of Immunology 55, e202451434 (2024)
Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications Biology 7, 31 (2024)
2023
The chilling origin of germinal centers. Science Immunology 8, eadl1470 (2023)
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system. Trends in Immunology 44, S. 372 - 383 (2023)
Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE. Cell Reports 42, 112933 (2023)
Origin and evolutionary malleability of T cell receptor α diversity. Nature 619, S. 193 - 200 (2023)
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells. Nature Communications 14, 3645 (2023)
MHC I tetramer staining tends to overestimate the number of functionally relevant self-reactive CD8 T cells in the pre-immune repertoire. European Journal of Immunology 53, 2350402 (2023)
A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons. BMC Immunology 24, 20 (2023)
Lymphocyte pathway analysis using naturally lymphocyte-deficient fish. European Journal of Immunology 53, e2350577 (2023)
2022
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Genes and Development 36, S. 901 - 915 (2022)
Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice. Communications Biology 5, 1037 (2022)
Stage-specific and cell type-specific requirements of ikzf1 during haematopoietic differentiation in zebrafish. Scientific Reports 12, 21401 (2022)
Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding. Communications Biology 5, 911 (2022)
Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Scientific Reports 12, 13554 (2022)
Developmental dynamics of two bipotent thymic epithelial progenitor types. Nature 606, S. 165 - 171 (2022)
2021
Male validation factor for three-spined stickleback (Gasterosteus aculeatus) mate choice likely evolutionarily conserved since 50 thousand years. Ethology, Ecology & Evolution 33, S. 25 - 36 (2021)
Antigen receptor repertoires of one of the smallest known vertebrates. Science Advances 7, eabd8180 (2021)
Evolution of thymopoietic microenvironments. Open Biology 11, 200383 (2021)
Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications Biology 4, 1201 (2021)
2020
Transgenerational inheritance of impaired larval T cell development in zebrafish. Nature Communications 11, S. 4505 (2020)
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience 23, 101260 (2020)
Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development. EBioMedicine 59, 102961 (2020)
Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Proceedings of the National Academy of Sciences of the United States of America 117, S. 15799 - 15808 (2020)
Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys. Science Immunology 5, eaba0925 (2020)
Lymphocyte-Specific Function of the DNA Plymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles. Cell Reports 31, 107756 (2020)
The immunogenetics of sexual parasitism. Science 369, S. 1608 - 1615 (2020)
Retracing the evolutionary emergence of thymopoiesis. Science Advances 6, eabd9585 (2020)
Co-evolution of mutagenic genome deditors and vertebrate adaptive immunity. Current Opinion in Immunology 65, S. 32 - 41 (2020)
2019
Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development. Proceedings of the National Academy of Sciences of the United States of America 116, S. 26759 - 26767 (2019)
2018
Evolution of Alternative Adaptive Immune Systems in Vertebrates. Annual Review of Immunology 36, S. 19 - 42 (2018)
Female assortative mate choice functionally validates synthesized male odours of evolving stickleback river–lake ecotypes. Biology Letters 14 (12), 20180730, S. 20180730 (2018)
Fundamental parameters of the developing thymic epithelium in the mouse. Scientific Reports 8, S. 11095 (2018)
Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys. Proceedings of the National Academy of Sciences of the United States of America 115, S. e3211 - e3220 (2018)
Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity. Proceedings of the National Academy of Sciences of the United States of America 115, S. E3201 - E3210 (2018)
Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. Journal of Experimental Medicine 215, S. 595 - 610 (2018)
Immunological tolerance to LCMV antigens differently affects control of acute and chronic virus infection in mice. European Journal of Immunology 48, S. 120 - 127 (2018)
2017
Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells. Methods in Cell Biology 138, S. 151 - 161 (2017)
Genetic and non-genetic determinants of thymic epithelial cell number and function. Scientific Reports 7, 10314 (2017)
Autoimmunity associated with chemically induced thymic dysplasia. International Immunology 29, S. 385 - 390 (2017)
Elevated levels of Wnt signaling disrupt thymus morphogenesis and function. Scientific Reports 7, S. 785 - 902 (2017)
Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size fo the functionally active thymic epithelial compartment. Scientific Reports 7, S. 8492 - 8496 (2017)
2016
Form follows function, function follows form: how lymphoid tissues enable and constrain immune reactions. Immunological Reviews 271, S. 4 - 9 (2016)
Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish. Scientific Reports 6, 19634 (2016)
Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports 17, S. 2259 - 2270 (2016)
2014
Origin and Evolution of Adaptive Immunity. Annual Review of Animal BioScience 2, S. 259 - 283 (2014)
Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates. Proceedings of the National Academy of Sciences of the United States of America 111, S. 14828 - 14833 (2014)
Selection of the lamprey VLRC antigen receptor repertoire. Proceedings of the National Academy of Sciences of the United States of America 111, S. 14834 - 14839 (2014)
Conversion of the Thymus into a Bipotent Lymphoid Organ by Replacement of Foxn1 with its Paralog Foxn4. Cell Reports 8, S. 1184 - 1197 (2014)
On the Origin of SCPP genes. Evolution and Development 16, S. 125 - 126 (2014)
Elephant shark genome provides unique insights into gnathostome evolution. Nature 505, S. 174 - 179 (2014)
2013
Sensory Biology. Nature 496, S. 304 - 305 (2013)
Same Function, Different Origins: Multipotent Stromal Precursors in Lymphoid Tissue. Cell Stem Cell 12, S. 501 - 503 (2013)
Thymus involution and regeneration: two sides of the same coin? Nature Reviews Immunology 13, S. 831 - 838 (2013)
Organization of lamprey variable lymphocyte receptor C locus and repertoire development. Proceedings of the National Academy of Sciences of the United States of America 110, S. 6043 - 6048 (2013)
Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Proceedings of the National Academy of Sciences of the United States of America 110, S. 4327 - 4332 (2013)
Evolutionary implications of a third lymphocyte lineage in lampreys. Nature 501, S. 435 - 438 (2013)
Major histocompatibility complex peptide ligands as olfactory cues in human body odour assessment. Proceedings of the Royal Society B: Biological Sciences 280, 20122889 (2013)
2012
Caught in the Act: Reprogramming of Adipocytes into Lymph-Node Stroma. Immunity 37, S. 596 - 598 (2012)
Evolution of Vertebrate Immunity. Current Biology 22, S. R722 - R732 (2012)
Self-renewal of thymocytes in the absence of competitive precursor replenishment. Journal of Experimental Medicine 209, S. 1397 - 1400 (2012)
Evolution of lymphoid tissues. Trends in Immunology 33, S. 315 - 321 (2012)
Evolution of the Immune System in the Lower Vertebrates. Annual Review of Genomics and Human Genetics 13, S. 127 - 149 (2012)
VLR-Based Adaptive Immunity. Annual Review of Immunology 30, S. 203 - 220 (2012)
Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments. Cell 149, S. 159 - 172 (2012)
Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions. Immunity 36, S. 298 - 309 (2012)
Regenerative capacity of adult cortical thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 109, S. 3463 - 3468 (2012)
2011
A thymus candidate in lampreys. Nature 470, S. 90 - 94 (2011)
Design principles of adaptive immune systems. Nature Reviews Immunology 11, S. 307 - 317 (2011)
Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proceedings of the National Academy of Sciences of the United States of America 108, S. 7517 - 7522 (2011)
Genetic Evidence for an Evolutionarily Conserved Role of IL-7 Signaling in T Cell Development of Zebrafish. Journal of Immunology 186, S. 7060 - 7066 (2011)
2010
Characterization of mononuclear phagocytic cells in medaka fish transgenic for a cxcr3a:gfp reporter. Proceedings of the National Academy of Sciences of the United States of America 107, S. 18079 - 18084 (2010)
Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage. Proceedings of the National Academy of Sciences of the United States of America 107, S. 16613 - 16618 (2010)
Costly major histocompatibility complex signals produced only by reproductively active males, but not females, must be validated by a "maleness signal" in three-spined sticklebacks. Proceedings of the Royal Society B: Biological Sciences 277, S. 391 - 398 (2010)
Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America 107, S. 17304 - 17308 (2010)
2009
Genetic Evidence for Monozygotic Twinning in Medaka Fish. Molecular Reproduction and Development 76, S. 430 (2009)
Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates. Cell 138, S. 186 - 197 (2009)
The adaptive phenotype of cortical thymic epithelial cells. European Journal of Immunology 39, S. 944 - 947 (2009)
One problem, two solutions. Nature Immunology 10, S. 811 - 813 (2009)
Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nature Neuroscience 12, S. 1551 - 1558 (2009)
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nature Genetics 41, S. 101 - 105 (2009)
Everything in its Place. Immunity 31, S. 856 - 858 (2009)
2008
Thymus development and function. Current Opinion in Immunology 20, S. 178 - 184 (2008)
Ltβr Signaling Does Not Regulate Aire-Dependent Transcripts in Medullary Thymic Epithelial Cells. Journal of Immunology 181, S. 400 - 407 (2008)
Maintenance of Thymic Epithelial Phenotype Requires Extrinsic Signals in Mouse and Zebrafish. Journal of Immunology 181, S. 5272 - 5277 (2008)
2007
Two in one: dual function of an invertebrate antigen receptor. Nature Immunology 8, S. 1031 - 1033 (2007)
The evolutionary history of lymphoid organs. Nature Immunology 8 (2), S. 131 - 135 (2007)
Back to the beginning - the quest for thymic epithelial stem cells. European Journal of Immunology 37, S. 2364 - 2366 (2007)
2006
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441, S. 992 - 996 (2006)
Quality Control in Self/Nonself Discrimination. Cell 125, S. 845 - 858 (2006)
Co-evolution of a primordial peptide-presentation system and cellular immunity. Nature Reviews Immunology 6, S. 79 - 84 (2006)
Thymus-homing precursors and the thymic microenvironment. Trends in Immunology 27, S. 477 - 484 (2006)
MHC peptides and the sensory evaluation of genotype. Trends in Neurosciences 29, S. 100 - 107 (2006)
Conserved Functions of Ikaros in Vertebrate Lymphocyte Development: Genetic Evidence for Distinct Larval and Adult Phases of T Cell Development and Two Lineages of B Cells in Zebrafish. Journal of Immunology 177, S. 2463 - 2476 (2006)
Essential Role of the Main Olfactory System in Social Recognition of Major Histocompatibility Complex Peptide Ligands. The Journal of Neuroscience 26, S. 1961 - 1970 (2006)
Weitere Publikationen von Thomas Boehm auf Pubmed.