Publications

Publications

Lab Akhtar

2021
Clapes, T.; Polyzou, A.; Prater, P.; Sagar; Morales-Hernández, A.; Ferrarini, M. G.; Kehrer, N.; Lefkopoulos, S.; Bergo, V.; Hummel, B. et al.; Obier, N.; Maticzka, D.; Bridgeman, A.; Herman, J. S.; Ilik, I.; Klaeylé, L.; Rehwinkel, J.; McKinney-Freeman, S.; Backofen, R.; Akhtar, A.; Cabezas-Wallscheid, N.; Sawarkar, R.; Rebollo, R.; Grün, D.; Trompouki, E.: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology (2021)
Karoutas, A.; Akhtar, A.: Functional mechanisms and abnormalities of the nuclear lamina. Nature Cell Biology 23, pp. 116 - 126 (2021)
Keller Valsecchi, C. I.; Basilicata, M. F.; Georgiev, P.; Gaub, A.; Seyfferth, J.; Kulkarni, T.; Panhale, A.; Semplicio, G.; Manjunath, V.; Holz, H. et al.; Dasmeh, P.; Akhtar, A.: RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, pp. 137 - 142 (2021)
2020
Pessoa Rodrigues, C.; Shvedunova, M.; Akhtar, A.: Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics 37, pp. 125 - 142 (2020)
Samata, M.; Alexia, A.; Richard, G.; Georgiev, P.; Nuebler, J.; Kulkarni, T.; Renschler, G. V.; Basilicata, M. F.; Zenk, F. L.; Shvedunova, M. et al.; Semplicio, G.; Mirny, L.; Iovino, N.; Akhtar, A.: Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell 182, pp. 127 - 144 (2020)
Sheikh, B. N.; Guhathakurta, S.; Tsang, T. H.; Schwabenland, M.; Renschler, G. V.; Herquel, B.; Bhardwaj, V.; Holz, H.; Stehle, T.; Bondareva, O. et al.; Aizarni, N.; Mossad, O.; Kretz, O.; Reichardt, W.; Chatterjee, A.; Braun, L. J.; Thevenon, J.; Sartelet, H.; Blank, T.; Grün, D.; von Elverfeldt, D.; Huber, T. B.; Vestweber, D.; Avilov, S.; Prinz, M.; Büscher, J. M.; Akhtar, A.: Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology 22, pp. 828 - 841 (2020)
Ilik, I. A.; Aktas, T.; Maticzka, D.; Backofen, R.; Akhtar, A.: FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research 48, p. e15 (2020)
Estrada Mallarino, L.; Engel, C.; Ilik, I. A.; Maticzka, D.; Heyl, F.; Müller, B.; Yakulov, T. A.; Dengjel, J.; Backofen, R.; Akhtar, A. et al.; Walz, G.: Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Scientific Reports 10, pp. 1 - 14 (2020)
Gaub, A.; Sheikh, B. N.; Basilicata, M. F.; Vincent, M.; Nizon, M.; Colson, C.; Bird, M. J.; Bradner, J. E.; Thevenon, J.; Boutros, M. et al.; Akhtar, A.: Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications 11, p. 2243 (2020)
Rodrigues, C. P.; Herman, J. S.; Herquel, B.; Velsecchi Keller, C. I.; Stehle, T.; Grün, D.; Akhtar, A.: Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances 6, p. eaaz4815 (2020)
2019
Sheikh, B. N.; Bondareva, O.; Guhathakurta, S.; Tsang, T. H.; Sikora, K.; Aizarani, N.; Sagar, S.; Holz, H.; Grün, D.; Hein, L. et al.; Akhtar, A.: Systematic Identification of Cell-Cell Communication Networks in the Developing Brain. iScience 21, pp. 273 - 287 (2019)
Renschler, G.; Gautier, R.; Claudia, V.; Toscano, S.; Arrigoni, L.; Ramírez, F.; Akhtar, A.: Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, pp. 1591 - 1612 (2019)
Karoutas, A.; Szymanski, W.; Rausch, T.; Guhathakurta, S.; Rog-Zielinska, E. A.; Peyronnet, R.; Seyfferth, J.; Chen, H.-R.; de Leeuw, R.; Herquel, B. et al.; Kimura, H.; Mittler, G.; Kohl, P.; Medalia, O.; Korbel, J. O.; Akhtar, A.: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology 21, pp. 1248 - 1260 (2019)
Bhardwaj, V.; Semplicio, G.; Erdogdu, N. U.; Manke, T.; Akhtar, A.: MapCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications 10, p. 3219 (2019)
Sheikh, B.; Guhathakurta, S.; Akhtar, A.: The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. EMBO Reports 20, p. e47360 (2019)
Lam, K.-C.; Chung, H.-R.; Semplicio, G.; Iyer, S. S.; Gaub, A.; Bhardwaj, V.; Holz, H.; Georgiev, P.; Akhtar, A.: The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, pp. 453 - 465 (2019)
Panhale, A.; Richter , F. M.; Ramírez, F.; Shvedunova, M.; Manke, T.; Mittler, G.; Akhtar, A.: CAPRI enables comparison of evolutionary conserved RNA interacting regions. Nature Communications 10, p. 2682 (2019)
Renschler, G.; Richard, G.; Keller Valsecchi, C. I.; Toscano, S.; Arrigoni, L.; Ramírez, F.; Akhtar, A.: Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, pp. 1591 - 1612 (2019)
Sheikh, B.; Akhtar, A.: Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics 20, pp. 7 - 23 (2019)
2018
Basilicata, M. F.; Bruel, A.-L.; Semplicio, G.; Keller Valsecchi, C. I.; Aktaş, T.; Duffourd, Y.; Rumpf, T.; Morton, J.; Bache, I.; Szymanski, W. G. et al.; Gilissen, C.; Vanakker, O.; Õunap, K.; Mittler, G.; van der Burgt, I.; Chehadeh, S. E.; Cho, M. T.; Pfundt, R.; Tan, T. Y.; Kirchhoff, M.; Menten, B.; Vergult, S.; Lindstrom, K.; Reis, A.; Johnson, D. S.; Fryer, A.; McKay, V.; Study, D.; Fisher, R. B.; Thauvin-Robinet, C.; Francis, D.; Roscioli, T.; Pajusalu, S.; Radtke, K.; Ganesh, J.; Brunner, H. G.; Wilson, M.; Faivre, L.; Kalscheuer, V. M.; Thevenon , J.; Akhtar, A.: De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nature Genetics, pp. 1442 - 1451 (2018)
Akhtar, A.: Finding your way through the science maze. Nature Genetics 20, p. 1000 (2018)
Samata, M.; Akhtar, A.: Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry, pp. 34.1 - 34.28 (2018)
Ramirez, F.; Bhardwaj, V.; Arrigoni, L.; Lam, K. C.; Grüning, B. A.; Villaveces, J.; Habermann, B.; Akhtar, A.; Manke, T.: High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications 9, p. 189 (2018)
Maticzka, D.; Ilik, I. A.; Aktas, T.; Backofen, R.; Akhtar, A.: uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins. Nature Communications 9, p. 1142 (2018)
Valsecchi Keller, C. I.; Basilicata , M. F.; Semplicio, G.; Georgiev, P.; Gutierrez, N. M.; Akhtar, A.: Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nature Communications 9, p. 3926 (2018)
2017
Ilik, I. A.; Maticzka, D.; Georgiev, P.; Gutierrez, N. M.; Backofen, R.; Akhtar, A.: A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes and Development 31, pp. 1973 - 1987 (2017)
Aktas, T.; Ilik, I. A.; Maticzka, D.; Bhardwaj, V.; Rodrigues , C. P.; Mittler, G.; Manke, T.; Backofen, R.; Akhtar, A.: DHX9 Suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 544, pp. 115 - 119 (2017)
2016
Chatterjee, A.; Seyfferth, J.; Lucci, J.; Glisbach, R.; Preissl, S.; Böttinger, L.; Martensson, C. U.; Panhale, A.; Stehle, T.; Kretz, O. et al.; Sahyoun, A. H.; Avilov, S.; Eimer, S.; Hein, L.; Pfanner, N.; Becker, T.; Akhtar, A.: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell 167, pp. 722 - 738 (2016)
Sheikh, B.N.; Bechtel-Walz, W.; Lucci, J.; Karpuik, O.; Hild, I.; Hartleben, B.; Vornweg, J.; Helmstädter, M.; Sahyoun, A.H.; Bhardwaj, V. et al.; Stehle, T.; Diehl, S.; Kretz, O.; Voss, A.K.; Thomas, T.; Manke, T.; Huber, T.B.; Akhtar, A.: MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35, pp. 2698 - 2710 (2016)
Quinn, J. J.; Zhang, Q. C.; Georgiev, P.; Ilik, I. A.; Akhtar, A.; Chang, H. Y.: Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes and Development 30, pp. 191 - 207 (2016)
Chlamydas, S.; Holz, H.; Samata, M.; Chelmicki, T.; Georgiev, P.; Pelechano, V.; Dündar, F.; Dasmeh, P.; Mittler, G.; Tavares Cadete, F. et al.; Ramirez, F.; Conrad, T.; Wei, W.; Raja, S.; Manke, T.; Luscombe, N. M.; Steinmetz, L. M.; Akhtar, A.: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural and Molecular Biology 23, pp. 580 - 589 (2016)
2015
Ramirez, F.; Lingg, T.; Toscano, S.; Lam, K.-C.; Georgiev, P.; Chung, H.-R.; Lajoie, B. R.; de Wit, E.; Zhan, Y.; de laat, W. et al.; Dekker, J.; Manke, T.; Akhtar, A.: High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell 60, pp. 146 - 162 (2015)
Meunier, S.; Shvedunova, M.; Van Nguyen, N.; Avila, l.; Vernos, I.; Akhtar, A.: An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications 6, p. 7889 (2015)
Keller, C. I.; Akhtar, A.: The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development 31, pp. 1 - 11 (2015)
2014
Bassett, A. R.; Akhtar, A.; Barlow, D. P.; Bird, A. P.; Brockdorff, N.; Duboule, D.; Ephrussi, A.; Ferguson-Smith, A. C.; Gingeras, T. R.; Haerty, W. et al.; Higgs, D. R.; Miska, E. A.; Ponting, C. P.: Considerations when investigating IncRNA function in vivo. eLife 3, p. e03058 (2014)
Chelmicki, T.; Dündar, F.; Turley, M. J.; Khanam, T.; Aktas, T.; Ramírez, F.; Gendrel, A.-V.; Wright, P. R.; Videm, P.; Backofen, R. et al.; Heard, E.; Manke, T.; Akhtar, A.: MOF-associated complexes ensure stem cell identity and Xist repression. eLife 3, p. e02024 (2014)
Dias, J.; Van Nguyen, N.; Georgiev, P.; Gaub, A.; Brettschneider, J.; Cusack, S.; Kadlec, J.; Akhtar, A.: Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes and Development 28, pp. 929 - 942 (2014)
Quinn, J. J.; Ilik, I. A.; Qu, K.; Georgiev, P.; Chu, C.; Akhtar, A.; Chang, H. Y.: Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature biotechnology 32, pp. 933 - 940 (2014)
2013
Ilik, I. A.; Quinn, J.; Georgiev, P.; Tavares-Cadete, F.; Maticzka, D.; Toscano, S.; Wan, Y.; Spitale, R. C.; Luscombe, N.; Backofen, R. et al.; Chang, H. Y.; Akhtar, A.: Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromsome Dosage Compensation in Drosophila. Molecular Cell 51, pp. 156 - 173 (2013)
2012
Hallacli, E.; Lipp, M.; Georgiev, P.; Spielman, C.; Cusack, S.; Akhtar, A.; Kadlec, J.: Msl1-Mediated Dimerization of the Dosage Compensation Complex is Essential for Male X-Chromosome Regulation in Drosophila. Molecular Cell 48, pp. 587 - 600 (2012)
Conrad, T.; Cavalli, F. M. G.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science 337, pp. 742 - 746 (2012)
Lam, K. C.; Mühlpfordt, F.; Vaquerizas, J. M.; Raja, S. J.; Holz, H.; Luscombe, N. M.; Manke, T.; Akhtar, A.: The NSL Complex Regulates Housekeeping Genes in Drosophila. PLoS Genetics 8, p. e1002736 - e1002736 (2012)
Conrad, T.; Cavalli, F. M. G.; Holz, H.; Hallacli, E.; Kind, J.; Ilik, I.; Vaquerizas, J. M.; Luscombe, N. M.; Akhtar, A.: The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. Developmental Cell 22, pp. 610 - 624 (2012)
Conrad, T.; Akhtar, A.: Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews: Genetics 13, pp. 123 - 134 (2012)
2011
Akhtar, A.; Fuchs, E.; Mitchison, T.; Shaw, R. J.; St Johnston, D.; Strasser, A.; Taylor, S.; Walczak, C.; Zerial, M.: A decade of molecular cell biology: achievements and challenges. Nature Reviews: Molecular Cell Biology 12, pp. 669 - 674 (2011)
Kadlec, J.; Hallacli, E.; Lipp, M.; Holz, H.; Sanchez-Weatherby, J.; Cusack, S.; Akhtar, A.: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Nature Structural & Molecular Biology 18, pp. 142 - 149 (2011)
Arib, G.; Akhtar, A.: Multiple facets of nuclear periphery in gene expression control. Current Opinion in Cell Biology 23, pp. 346 - 353 (2011)
Georgiev, P.; Chlamydas, S.; Akhtar, A.: Drosophila dosage compensation. Fly 5, pp. 147 - 154 (2011)
2010
Andersen, D. S.; Raja, S. J.; Colombani, J.; Shaw, R. L.; Langton, P. F.; Akhtar, A.; Tapon, N.: Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. Molecular and Cellular Biology 30, pp. 4744 - 4755 (2010)
Raja, S. J.; Charapitsa, I.; Conrad, T.; Vaquerizas, J. M.; Gebhardt, P.; Holz, H.; Kadlec, J.; Fraterman, S.; Luscombe, N. M.; Akhtar, A.: The Nonspecific Lethal Complex is a Transcriptional Regulator in Drosophila. Molecular Cell 38, pp. 827 - 841 (2010)
Laverty, C.; Lucci, J.; Akhtar, A.: The MSL complex: X chromsome and beyond. Current Opinion in Genetics & Development 20, pp. 171 - 178 (2010)
Vaquerizas, J. M.; Ritsuko, S.; Kind, J.; Miura, K.; Luscombe, N. M.; Akhtar, A.: Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome. PLoS Genetics 6, p. e1000846 - e1000846 (2010)
2009
Hallacli, E.; Akhtar, A.: X chromosomal regulation in flies: when less is more. Chromosome Research, pp. 603 - 619 (2009)
Ilik, I.; Akhtar, A.: roX RNAs. RNA Biology 6, pp. 113 - 121 (2009)
Zhou, Y.; Schmitz, K.-M.; Mayer, C.; Yuan, X.; Akhtar, A.; Grummt, I.: Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nature Cell Biology 11, pp. 1010 - 1016 (2009)
2011
Vaquerizas, J. M.; Akhtar, A.; Luscombe, N. M.: Large-scale nuclear architecture and transcriptional control. In: Subcellular Biochemistry, Vol. 12, pp. 669 - 674. Springer (2011)

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