
Publikationen
Labor Akhtar
2025
KANSL3 directs transcriptional programs essential for hepatic metabolism and differentiation. Life science alliance 8 (2025)
Protocol to isolate stress granules in HeLa cells using fluorescence-activated non-membrane condensate isolation. STAR Protocols 6, 103987 (2025)
Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis. Nature Cell Biology 27, S. 1482 - 1495 (2025)
2024
Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes. Immunity 57, S. 2216 - 2231 (2024)
MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation. Cell Reports 43, 114682 (2024)
YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment. Cell Reports 43, 114456 (2024)
Nuclei facing the tissue surface get fuel for development. Nature 630, S. 312 - 314 (2024)
RNA damage compartmentalization by DHX9 stress granules. Cell 187, S. 1701 - 1718 (2024)
2023
MSL2 ensures biallelic gene expression in mammals. Nature 624, S. 173 - 181 (2023)
COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nature Metabolism 5, S. 1931 - 1952 (2023)
Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells. Science Advances 9, eadh5598 (2023)
The NSL complex is required for piRNA production from telomeric clusters. Life science alliance 6, e202302194 (2023)
Asifa Akhtar. Current Biology 33, S. R286 - R287 (2023)
2022
Modulation of cellular processes by histone and non-histone protein acetylation. Nature Reviews Molecular Cell Biology 23, S. 329 - 349 (2022)
2021
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice. Nature Communications 12, 6212 (2021)
Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science Advances 7 (32), eabi5987 (2021)
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life science alliance 4, e202000996 (2021)
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology 23, S. 704 - 717 (2021)
Functional mechanisms and abnormalities of the nuclear lamina. Nature Cell Biology 23, S. 116 - 126 (2021)
2020
RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, S. 137 - 142 (2020)
Epigenetic Regulators as the Gatekeepers of Hematopoiesis. Trends in Genetics 37, S. 125 - 142 (2020)
Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell 182, S. 127 - 144 (2020)
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nature Cell Biology 22, S. 828 - 841 (2020)
FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucelic Acids Research 48, S. e15 (2020)
Nephronophthisis gene products display RNA-binding properties and are recruited to stress granules. Scientific Reports 10, S. 1 - 14 (2020)
Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications 11, S. 2243 (2020)
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances 6, S. eaaz4815 (2020)
2019
Systematic Identification of Cell-Cell Communication Networks in the Developing Brain. iScience 21, S. 273 - 287 (2019)
Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, S. 1591 - 1612 (2019)
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology 21, S. 1248 - 1260 (2019)
MapCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications 10, S. 3219 (2019)
CAPRI enables comparison of evolutionary conserved RNA interacting regions. Nature Communications 10, 2682 (2019) (2019)
The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. EMBO Reports 20, S. e47360 (2019)
The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, S. 453 - 465 (2019)
Many lives of KATs - detector, integrator and modulator of cellular environment. Nature Reviews Genetics 20, S. 7 - 23 (2019)
2018
De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation. Nature Genetics, S. 1442 - 1451 (2018)
Finding your way through the science maze. Nature Genetics 20, S. 1000 (2018)
Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry 87, S. 323 - 350 (2018)
High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications 9, S. 189 (2018)
uvCLAP is a fast and non-radioactive method to identify in vivo targets of RNA-binding proteins. Nature Communications 9, S. 1142 (2018)
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nature Communications 9, S. 3926 (2018)
2017
A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes and Development 31, S. 1973 - 1987 (2017)
DHX9 Suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature 544, S. 115 - 119 (2017)
2016
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell 167, S. 722 - 738 (2016)
MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35, S. 2698 - 2710 (2016)
Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes and Development 30, S. 191 - 207 (2016)
Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural and Molecular Biology 23, S. 580 - 589 (2016)
2015
High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell 60, S. 146 - 162 (2015)
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications 6, 7889 (2015) (2015)
The MSL complex: juggling RNA-protein interaction for dosage compensation and beyond. Current Opinion in Genetics & Development 31, S. 1 - 11 (2015)
2014
Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs). Medicinal Chemistry Communications 5, S. 1856 - 1862 (2014)
Considerations when investigating IncRNA function in vivo. eLife 3, e03058 (2014)
MOF-associated complexes ensure stem cell identity and Xist repression. eLife 3, S. e02024 (2014)
Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes and Development 28, S. 929 - 942 (2014)
Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature biotechnology 32, S. 933 - 940 (2014)
2013
Tandem Stem-Loops in roX RNAs Act Together to Mediate X Chromsome Dosage Compensation in Drosophila. Molecular Cell 51, S. 156 - 173 (2013)
2012
Msl1-Mediated Dimerization of the Dosage Compensation Complex is Essential for Male X-Chromosome Regulation in Drosophila. Molecular Cell 48, S. 587 - 600 (2012)
Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters. Science 337, S. 742 - 746 (2012)
The NSL Complex Regulates Housekeeping Genes in Drosophila. PLoS Genetics 8, S. e1002736 - e1002736 (2012)
The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex. Developmental Cell 22, S. 610 - 624 (2012)
Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics 13, S. 123 - 134 (2012)
2011
A decade of molecular cell biology: achievements and challenges. Nature Reviews Molecular Cell Biology 12, S. 669 - 674 (2011)
Drosophila dosage compensation: males are from Mars, females are from Venus. Fly 5, S. 147 - 154 (2011)
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Nature Structural & Molecular Biology 18, S. 142 - 149 (2011)
Multiple facets of nuclear periphery in gene expression control. Current Opinion in Cell Biology 23, S. 346 - 353 (2011)
2010
Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. Molecular and Cellular Biology (Washington, DC) 30, S. 4744 - 4755 (2010)
The Nonspecific Lethal Complex is a Transcriptional Regulator in Drosophila. Molecular Cell 38, S. 827 - 841 (2010)
The MSL complex: X chromsome and beyond. Current Opinion in Genetics & Development 20, S. 171 - 178 (2010)
Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome. PLoS Genetics 6, S. e1000846 - e1000846 (2010)
2009
X chromosomal regulation in flies: when less is more. Chromosome Research, S. 603 - 619 (2009)
roX RNAs. RNA Biology 6, S. 113 - 121 (2009)
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nature Cell Biology 11, S. 1010 - 1016 (2009)
2011
Large-scale nuclear architecture and transcriptional control. In: Subcellular Biochemistry, Bd. 12, S. 669 - 674. Springer (2011)
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