Function of neuron-specific 3’ UTRs
Neuron-specific ultra-long 3’UTRs also occur in humans; their function is unknown.
We think that a balanced expression of ultra-long 3’UTRs limits phenotypes of neurodegeneration in disease and in normal aging. Our findings indicate that deleting the neuron-specific part of mRNA sequences can cause serious neurological phenotypes in vivo.
We aim to establish the functional impact of ultra-long 3’UTRs on neuronal function. Approaches include functional genetics, behavior analysis, single-molecule imaging, proteomics and transcriptomics.