Publikationen von Edward Jonathen Pearce

Zeitschriftenartikel (67)

2021
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Stanczak, M. A.; Sanin, P. D. E.; Apostolova, P.; Nerz, G.; Lampaki, D.; Hofmann, M.; Steinmann, D.; Krohn-Grimberghe, M.; Thimme, R.; Mittler, G. et al.; Waller, C. F.; Pearce, E. J.; Pearce, E. L.: IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications 12, S. 2133 (2021)
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Dudek, M.; Pfister, D.; Donakonda, S.; Filpe, P.; Schneider, A.; Laschinger, M.; Hartmann, D.; Hüser, N.; Meiser, P.; Bayerl, F. et al.; Inverso, D.; Wigger, J.; Sebode, M.; Öllinger, R.; Rad, R.; Hegenbarth, S.; Anton, M.; Guillot, A.; Bowman, A.; Heide, D.; Müller, F.; Ramadori, P.; Leone, V.; Garcia-Caceres, C.; Gruber, T.; Seifert, G.; Kabat, A.; Malm, J.-P.; Reider, S.; Effenberger, M.; Roth, S.; Billeter, A. T.; Müller-Stich, B.; Pearce, E. J.; Koch-Nolte, F.; Käser, R.; Tilg, H.; Thimme, R.; Böttler, T.; Tacke, F.; Dufour, J.-F.; Haller, D.; Murray, P. J.; Heeren, R.; Zehn, D.; Böttcher, J. P.; Knolle, M. H. P. A.: Auto-aggressive CXCR6 CD8 T cells cause liver immune pathology in NASH. Nature 592, S. 444 - 449 (2021)
2020
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Kapoor, T.; Corrado, M.; Pearce, E. L.; Pearce, E. J.; Grosschedl, R.: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports 10, 21626 (2020) (2020)
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Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.; Quintana, A.; Jonathan, C.; Clapes, T.; Grzes, K.; Kabat, A.; Ryan, K.; Annette, E. P.; Klein-Geltink, R.; Amulic, B.; Steward, C. G.; Strathdee, D.; Trompouki, E.; O'Sullivan, D.; Pearce, E. J.; Pearce, E. L.: Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metabolism 32, S. 981 - 995 (2020)
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Remmerie, A.; Martens, L.; ́Thone, T.; Castoldi, A.; Seurinck, R.; Pavie, B.; Roels, J.; Vanneste, B.; Prijck, S. D.; Vanhockerhout, M. et al.; Latib, M. B. A.; Devisscher, L.; Hoorens, A.; Bonnardel, J.; Vandamme, N.; Kremer, A.; Borghgraef, P.; Vlierberghe, H. V.; Lippens, S.; Pearce, E. J.; Saeys, Y.; Scott, a. C. L.: Osteopontin Expression Identifies a Subsetof Recruited Macrophages Distinctfrom Kupffer Cells in the Fatty Liver. Immunity 53, S. 641 - 657 (2020)
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Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.; Kabat, A.; Stanczak, M.; Curtis, J.; Hässler, F.; Uhl, F. M.; Fabri, M.; Zeiser, R.; Pearce, E. J.; Pearce, E. L.: Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nature Metabolism 2, S. 703 - 716 (2020)
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van Teijlingen Bakker, N.; Pearce, E. J.: Cell-intrinsic metabolic regulation of mononuclear activation: Findings from the tip of the iceberg. Immunological Reviews 295, S. 54 - 67 (2020)
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Field, C.; Baixauli Celda, F.; Puleston, D.; Kyle, R.; Alana, C.; Sanin, P. D. E.; Hippen, K. L.; Loschi, M.; Thangavelu, G.; Corrado, M. et al.; Edwards-Hicks, J.; Grzes, K.; Pearce, E. J.; Blazar, B. R.; Pearce, E. L.: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function. Cell Metabolism 31, S. 422 - 437 (2020)
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Castoldi, A.; Monteiro, L. B.; van Bakker, N. T.; Sanin, D. E.; Rana, N.; Corrado, M.; Cameron, A. M.; Hässler, F.; Matsushita, M.; Caputa, G. et al.; Geltink, R. I. K.; Büscher, J.; Edwards-Hicks, J.; Pearce, E. L.; Pearce, E. J.: Triacylglycerol synthesis enhances macrophage inflammatory function. Nature Communications 11, S. 1 - 11 (2020)
2019
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Caputa, G.; Castoldi, A.; Pearce, E. J.: Metabolic adaptations of tissue-resident immune cells. Nature Immunology 20, S. 793 - 801 (2019)
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Qiu, J.; Villa, M.; Sanin, P. D. E.; Buck, M. D.; O’Sullivan, D.; Ching, R. W.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Jonathan, D. C.; Kyle, R. L.; Bakker, N. V. T.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, S. 2063 - 2074 (2019)
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O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, S. 324 - 334 (2019)
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Cameron, A. M.; Castoldi, A.; Sanin, D. E.; Flachsmann, L. J.; Field, C. S.; Puleston, D. J.; Kyle, R. L.; Patterson, A.; Hassler, F.; Buescher, J. M. et al.; Kelly, B.; Pearce, E. L.; Pearce, E. J.: Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage. Nature Immunology 20, S. 420 - 432 (2019)
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Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.; Zhang, Y.; Flachsmann, L. J.; Field, C. S.; Patterson, A. E.; Scherer, S.; Alfei, F.; Baixauli, F.; Austin, S. K.; Kelly, B.; Matsushita, M.; Curtis, J. D.; Grzes, K. M.; Villa, M.; Corrado, M.; Sanin, D. E.; Qiu, J.; Pällman, N.; Paz, K.; Maccari, M. E.; Blazar, B. R.; Mittler, G.; Büscher, J.; Zehn, D.; Rospert, S.; Pearce, E. J.; Balabanov, S.; Pearce, E. L.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, S. 1 - 12 (2019)
2018
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Sanin, D. E.; Matsushita, M.; Klein-Geltink, R.; Grzes, K.; van Bakker, N. T.; Corrado, M.; Kabat, A.; Buck, M. D.; Qiu, J.; Lawless, S. J. et al.; Cameron, A.; Villa, M.; Baixauli Celda, F.; Patterson, A. E.; Hässler, F.; Curtis, J. D.; O’Neill, C. M.; O'Sullivan, D.; Wu, D.; Mittler, G.; Huang, S. C.-C.; Pearce, E. L.; Pearce, E. J.: Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity 49, S. 1021 - 1033 (2018)
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Cortes-Selva, D.; Elvington, A. F.; Ready, A.; Rajwa, B.; Pearce, E. J.; Randolph, G. J.; Fairfax, K. C.: Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype. Frontiers in immunology 9, S. 2580 (2018)
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Matushita, M.; Pearce, E. J.: Disrupting metabolism to treat autoimmunity: Dimethyl fumarate, a treatment ofr multiple sclerosis, inhibits Warburg metabolism. Science 360, S. 377 - 378 (2018)
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Pearce, E. J.; Pearce, E. L.: Immunometabolism in 2017: Driving immunity: all roads lead to metabolism. Nature Reviews Immunology 18, S. 81 - 82 (2018)
2017
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Geltink, R. I. K.; O’Sullivan, D.; Corrado, M.; Bremser, A.; Buck, M. D.; Buescher, J. M.; Firat, E.; Zhu, X.; Niedermann, G.; Caputa, G. et al.; Kelly, B.; Warthorst, U.; Rensing-Ehl, A.; Kyle, R. L.; Vandersarren, L.; Curtis, J. D.; Patterson, A. E.; Lawless, S.; Grzes, K.; Qiu, J.; Sanin, D. E.; Kretz, O.; Huber, T. B.; Janssens, S.; Lambrecht, B. N.; Rambold, A.; Pearce, E. J.; Pearce, E. L.: Mitochondrial Priming by CD28. Cell 171, S. 385 - 397 (2017)
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Grzes, K.; Field, C.; Pearce, E. J.: Treg Cells Survive and Thrive in Inhospitable Environments. Cell Metabolism 25, S. 1213 - 1215 (2017)
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Jones, R. G.; Pearce, E. J.: MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells. Immunity 46, S. 730 - 742 (2017)
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Kabat, A.; Pearce, E. J.: Inflammation by way of macrophage metabolism. Science 356, S. 488 - 489 (2017)
2016
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Cameron , A. M.; Lawless, S. J.; Pearce, E. J.: Metabolism and acetylation in innnate immune cell function and fate. Seminars in Immunology 28, S. 408 - 416 (2016)
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Huang, S. C.-C.; Smith, A. M.; Everts, B.; Colonna, M.; Pearce, E. L.; Schilling, J. D.; Pearce, E. J.: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation. Immunity 45, S. 817 - 830 (2016)
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Boukhaled, G. M.; Cordeiro, B.; Deblois, G.; Dimitrov, V.; Bailey, S. D.; Holowka, T.; Domi, A.; Guak, H.; Chiu, H.-H. C.; Everts, B. et al.; Pearce, E. J.; Lupien, M.; White, J. H.; Krawczyk, C. M.: The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence. Cell 16, S. 1829 - 1837 (2016)
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Buck, M. D.; O’Sullivan, D.; Geltink, R. I. K.; Curtis, J. D.; Chang, C.-H.; Sanin, D. E.; Qiu, J.; Kretz, O.; Braas, D.; van der Windt, G. J.W. et al.; Chen, Q.; Huang, S. C.-C.; O’Neill, C. M.; Edelson, B. T.; Pearce, E. J.; Sesaki, H.; Huber, T. B.; Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell 166, S. 63 - 76 (2016)
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Wu, D.; Sanin, D. E.; Everts, B.; Chen, Q.; Qiu, J.; Buck, M. D.; Patterson, A.; Smith, A. M.; Chang, C.-H.; Liu, Z. et al.; Artyomov, M. N.; Pearce, E. J.; Cella, M.; Pearce, E. J.: Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function. Immunity 44, S. 1325 - 1326 (2016)
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Kaiko, G. E.; Ryu, S. H.; Koues, O. I.; Collins, P. L.; Solnica-Krezel, L.; Pearce, E. J.; Pearce, E. L.; Oltz, E. M.; Stappenbeck, T. S.: The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell 167, S. 1708 - 1720 (2016)
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O'Neill, L. A.J.; Pearce, E. J.: Immunometabolism governs dendritic cell and macrophage function. Journal of Experimental Medicine 213, S. 15 - 23 (2016)
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Everts, B.; Tussiwand, R.; Dreesen, L.; Fairfax, K. C.; Huang, S. C.-C.; Smith, A. M.; O’Neill, C. M.; Lam, W. Y.; Edelson, B. T.; Urban, J. F. J. et al.; Murphy, K. M.; Pearce, E. J.: Migratory CD103+ dendritic cells suppress helminth-driven Type2 immunity through constitutive expression of IL-12. Journal of Experimental Medicine 213, S. 35 - 51 (2016)
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