em. Prof. Dr. Rudolf Grosschedl
em. Prof. Dr. Rudolf Grosschedl
Emeritus Direktor und Gruppenleitung
Telefon:+49 761 5108-711
Marika Rott
Telefon:+49 761 5108-711

Labor Rudolf Grosschedl


  1. 2020
    Wang, Y.; Zolotarev, N.; Yang, C.-Y.; Rambold, A.; Mittler, G.; Grosschedl, R.: A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin. Immunity 53, S. 1 - 17 (2020)
  2. Kucinski, I.; Wilson, N. K.; Hannah, R.; Kinston, S. J.; Cauchy, P.; Lenaerts, A.; Grosschedl, R.; Göttgens, B.: Interactions between lineage-associated transcription factors govern haematopoietic progenitor states. The EMBO Journal, S. e104983 (2020)
  3. Derecka, M.; Herman, J. S.; Cauchy, P.; Ramamoorthy, S.; Lupar, E.; Grün, D.; Grosschedl, R.: EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential. Nature 21, S. 261 - 273 (2020)
  4. Kapoor, T.; Corrado, M.; Pearce, E. L.; Pearce, E. J.; Grosschedl, R.: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports 10 (2020)
  5. Ramamoorthy, S.; Kometani, K.; Herman, J. S.; Bayer, M.; Boller, S.; Edwards-Hicks, J.; Ramachandran, H.; Li, R.; Klein-Geltink, R.; Pearce, E. L. et al.; Grün, D.; Grosschedl, R.: EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes and Development 34, S. 1503 - 1519 (2020)
  6. 2018
    Tinterri, A.; Menardy, F.; Diana, M. A.; Lokmane, L.; Keita, M.; Coulpier, F.; Lemoine, S.; Mailhes, C.; Mathieu, B.; Merchan-Sala, P. et al.; Campbell, K.; Gyory, I.; Grosschedl, R.; Popa, D.; Garel, S.: Active intermixing of indirect and direct neurons builds the striatal mosaic. Nature Communications 9, S. 4725 (2018)
  7. Yanai, H.; Chiba, S.; Hangai, S.; Kometani, K.; Inoue, A.; Kimura, Y.; Abe, T.; Kiyonari, H.; Nishio, J.; Taguchi-Atarashi, N. et al.; Mizushima, Y.; Negishi, H.; Grosschedl, R.; Taniguchi, T.: Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proceedings of the National Academy of Sciences of the United States of America 115, S. 5253 - 5258 (2018)
  8. Boller, S.; Li, R.; Grosschedl, R.: Defining B Cell Chromatin: Lessons from EBF1. Trends in Genetics 34, S. 257 - 269 (2018)
  9. Li , R.; Cauchy, P.; Ramamoorthy, S.; Boller, S.; Chevez, L.; Grosschedl, R.: Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Genes and Development 32, S. 96 - 111 (2018)
  10. Andreani, V.; Ramamoorthy, S.; Pandey, A.; Lupar, E.; Nutt, S. L.; Lämmermann, T.; Grosschedl, R.: Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function. Proceedings of the National Academy of Sciences of the United States of America 115, S. E9630 - E9639 (2018)
  11. Musa, Y. R.; Boller, S.; Puchalska, M.; Grosschedl, R.; Mittler, G.: Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Ulilizing Data Independent Acquisition. Journal of Proteome Research 17, S. 76 - 85 (2018)
  12. 2017
    Rodríguez-Gil, A.; Ritter, O.; Saul, V. V.; Wilhelm, J.; Yang, C.-Y.; Grosschedl, R.; Imai, Y.; Kuba, K.; Kracht, M.; Schmitz, M. L.: The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Scientific Reports, S. 3547 (2017)
  13. 2016
    Yang, C.-Y.; Ramamoorthy, S.; Boller, S.; Rosenbaum, M.; Gil, A. R.; Mittler, G.; Imai, Y.; Kuba, K.; Grosschedl, R.: Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis. Genes and Development 30, S. 2310 - 2324 (2016)
  14. Schnappauf, O.; Beyes, S.; Dertmann, A.; Freihen, V.; Frey, P.; Rose, K.; Michoel, T.; Grosschedl, R.; Hecht, A.: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. Biochimica et Biophysica Acta (BBA) 1859, S. 1353 - 1367 (2016)
  15. Hilde, K. L.; Levine, A. J.; Hinckley, C. A.; Montgomery, J. M.; Gullo, M.; Driscoll, S. P.; Grosschedl, R.; Kohwi, Y.; Kohwi-Shigematsu, T.; Pfaff, S.: Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position. Neuron 91, S. 763 - 776 (2016)
  16. Boller, S.; Ramamoorthy, S.; Akbas, D.; Nechanitzky, R.; Burger, L.; Murr, R.; Schübeler, D.; Grosschedl, R.: Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming. Immunity 44, S. 527 - 541 (2016)
  17. 2015
    Leone, D. P.; Heavner, W. E.; Ferenczi, E. A.; Dobreva, G.; Huguendard, J. R.; Grosschedl, R.; McConnell, S. K.: Satb2 Regulates the differntiationof Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cerebral Cortex 25, S. 3406 - 3419 (2015)
  18. Ramachandran, H.; Herfurth, K.; Grosschedl, R.; Schäfer, T.; Walz, G.: SUMOylation Blocks the Ubiquitin-Mediated Degradatoin of the Nephronophthisis Gene Product Glis2/NPHP7. Plos One 10, S. e0130275 (2015)
  19. 2014
    Boller, S.; Grosschedl, R.: The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. Immunological Reviews, S. 102 - 115 (2014)
  20. Grosschedl, R.: Establishment and Maintenance of B cell Identity. Cold Spring Harbor Symposia on Quantitative Biology 78, S. 23 - 30 (2014)
  21. Okosun, J.; Bödör, C.; Wang, J.; Araf, S.; Yang, C.-Y.; Pan, C.; Boller, S.; Cittaro, D.; Bozek, M.; Iqbal, S. et al.; Matthews, J.; Wrench, D.; Marzec, J.; Tawana, K.; Popov, N.; O'riain, C.; O'Shea, D.; Carlotti, E.; Davies, A.; Lawrie, C. H.; Matolcsy, A.; Calaminici, M.; Norton, A.; Byers, R. J.; Mein, C.; Stupka, E.; Lister, T. A.; Lenz, G.; Montoto, S.; Gribben, J. G.; Fan, Y.; Grosschedl, R.; Chelala, C.; Fitzgibbon, J.: Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nature Genetics 46, S. 176 - 181 (2014)
  22. Rosenbaum, M.; Andreani, V.; Kapoor, T.; Herp, S.; Flach, H.; Duchniewicz, M.; Grosschedl, R.: MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes & Development 28, S. 1165 - 1178 (2014)
  23. 2013
    Nechanitzky, R.; Akbas, D.; Scherer, S.; Györy, I.; Hoyler, T.; Ramamoorthy, S.; Diefenbach, A.; Grosschedl, R.: Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nature Immunology 14, S. 867 - 875 (2013)
  24. Lokmane, L.; Proville, R.; Narboux-Neme, N.; Györy, I.; Keita, M.; Mailhes, C.; Léna, C.; Gaspar, P.; Grosschedl, R.; Garel, S.: Sensory Map Transfer to the Neocrotex Relies on Pretarget Ordering of Thalamic Axons. Current Biology 23, S. 810 - 816 (2013)
  25. Zee, T.; Boller, S.; Györy, I.; Makinistoglu, M. P.; Tuckermann, J. P.; Grosschedl, R.; Karsenty, G.: The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Letters 587, S. 711 - 716 (2013)
  26. 2012
    Srinivasan, K.; Leone, D. P.; Bateson, R. K.; Dobreva, G.; Kohwi, Y.; Kohwi-Shigematsu, T.; Grosschedl, R.; McConnell, S. K.: A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proceedings of the National Academy of Sciences U.S.A. 109, S. 19071 - 19078 (2012)
  27. Nechanitzky, R.; Dávila, A.; Savarese, F.; Fietze, S.; Grosschedl, R.: Satb1 and Satb2 Are Dispensable for X Chromosome Inactivation in Mice. Developmental Cell 23, S. 866 - 871 (2012)
  28. Skokowa, J.; Klimiankou, M.; Klimenkova, O.; Lan, D.; Gupta, K.; Hussein, K.; Carrizosa, E.; Kusnetsova, I.; Li, Z.; Sustmann, C. et al.; Ganser, A.; Zeidler, C.; Kreipe, H.-H.; Burkhardt, J.; Grosschedl, R.; Welte, K.: Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nature Medicine 18, S. 1550 - 1559 (2012)
  29. Györy, I.; Boller, S.; Nechanitzky, R.; Mandel, E.; Pott, S.; Liu, E.; Grosschedl, R.: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes & Development 26, S. 668 - 682 (2012)
  30. Wei, J.; Shi, Y.; Zheng, L.; Zhou, B.; Inose, H.; Wang, J.; Guo, X. E.; Grosschedl, R.; Karsenty, G.: miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. The Journal of Cell Biology 197, S. 509 - 521 (2012)
  31. 2011
    Zhang, J.; Tu, Q.; Grosschedl, R.; Kim, M. S.; Griffin, T.; Drissi, H.; Yang, P.; Chen, J.: Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Engineering 17, S. 1767 - 1776 (2011)
  32. 2010
    Flach, H.; Rosenbaum, M.; Duchniewicz, M.; Kim, S.; Zhang, S. L.; Cahalan, M. D.; Mittler, G.; Grosschedl, R.: Mzb1 Protein Regulates Calcium Homeostasis, Antibody Secretion, and Integrin Activation in Innate-like B Cells. Immunity 33, S. 723 - 735 (2010)
  33. Kieslinger, M.; Hiechinger, S.; Dobreva, G.; Consalez, G. G.; Grosschedl, R.: Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner. Cell Stem Cell 7, S. 496 - 507 (2010)
  34. Mandel, E. M.; Grosschedl, R.: Transcription control of early B cell differentiation. Current Opinion in Immunology 22, S. 161 - 167 (2010)
  35. Sen, R.; Grosschedl, R.: Memories of lost enhancers. Genes and Development 2, S. 973 - 979 (2010)
  36. Treiber, N.; Treiber, T.; Zocher, G.; Grosschedl, R.: Structure of an Ebf1: DNA complex reveals unusual DNA recognition and structural homology with Rel proteins. Genes and Development 24, S. 2270 - 2275 (2010)
  37. Treiber, T.; Mandel, E. M.; Pott, S.; Györy, I.; Firner, S.; Liu, E. T.; Grosschedl, R.: Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression and Transcription - Independent Poising of Chromatin. Immunity 32, S. 714 - 725 (2010)
  38. 2009
    Savarese, F.; Dávila, A.; Nechanitzky, R.; De La Rosa-Velazquez, I.; Pereira, C. F.; Engelke, R.; Takahashi, K.; Jenuwein, T.; Kohwi-Shigematsue, T.; Fisher, A. et al.; Grosschedl, R.: Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes & Development 23, S. 2625 - 2638 (2009)
  39. 2008
    Sustmann, C.; Flach, H.; Ebert, H.; Eastman, Q.; Grosschedl, R.: Cell-Type-Specific Function of BCL9 Involves a Transcriptional Activation Domain that Synergizes with β-Catenin. Molecular and Cellular Biology 28, S. 3526 - 3537 (2008)
  40. Dawlaty, M. M.; Malureanu, L.; Jeganathan, K. B.; Kao, E.; Sustmann, C.; Tahk, S.; Shuai, K.; Grosschedl, R.; van Deursen, J. M.: Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα. Cell 133, S. 103 - 115 (2008)
  41. Nielsen, P.; Grosschedl, R.: Multitasking of Interferon Regulatory Factor-4 in Early B Cells. Immunity 28, S. 295 - 297 (2008)
  42. Alcamo, E. A.; Chirivella, L.; Dautzenberg, M.; Dobreva, G.; Farinas, I.; Grosschedl, R.; McConnell, S. K.: Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex. Neuron 57, S. 364 - 377 (2008)
  43. Pongubala, J. M. R.; Northrup, D. L.; Lancki, D. W.; Medina, K. L.; Treiber, T.; Bertolino, E.; Thomas, M.; Grosschedl, R.; Allman, D.; Singh, H.: Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nature Immunology 9, S. 203 - 215 (2008)
  44. 2007
    Iwatsuki, K.; Liu, H.-X.; Gründer, A.; Singer, M.; Lane, T. F.; Grosschedl, R.; Mistretta, C.; Margolskee, R. F.: Wnt signaling interacts with Shh to regulate taste papilla development. Proceedings of the National Academy of Sciences of the United States of America 104, S. 2253 - 2258 (2007)
  45. Roessler, S.; Györy, I.; Imhof, S.; Spivakov, M.; Williams, R. R.; Busslinger, M.; Fischer, A. G.; Grosschedl, R.: Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5. Molecular and Cellular Biology 27, S. 579 - 594 (2007)
  46. Schneider, R.; Grosschedl, R.: Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes & Development 21, S. 3027 - 3043 (2007)
  47. Tolkunova, E.; Malashicheva, A.; Parfenov, V. N.; Sustmann, C.; Grosschedl, R.; Tomilin, A.: PIAS Proteins as Repressors of Oct4 Function. Journal of Molecular Biology 374, S. 1200 - 1212 (2007)
  48. 2006
    Skokowa, J.; Cario, G.; Uenalan, M.; Schambach, A.; Germeshausen, M.; Battmer, K.; Zeidler, C.; Lehmann, U.; Eder, M.; Baum, C. et al.; Grosschedl, R.; Stanulla, M.; Scherr, M.; Welte, K.: LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nature Medicine 12, S. 1191 - 1197 (2006)
  49. Savarese, F.; Grosschedl, R.: FOXtrot and RAGtime in B cells. Nature Immunology 7, S. 793 - 794 (2006)
  50. Savarese, F.; Grosschedl, R.: Blurring cis and trans in Gene Regulation. Cell 126, S. 248 - 250 (2006)
  51. Dobreva, G.; Chahrour, M.; Dautzenberg, M.; Chirivella, L.; Kanzler, B.; Farinas, I.; Karsenty, G.; Grosschedl, R.: SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation. Cell 125, S. 971 - 986 (2006)
  52. Olson, L. E.; Tollkuhn, J.; Scafoglio, C.; Krones, A.; Zhang, J.; Ohgi, K. A.; Wu, W.; Taketo, M.; Kemler, R.; Grosschedl, R. et al.; Rose, D.; Li, X.: Homeodomain-Mediated β-Catenin-Dependent Switching events Dictate Cell-Lineage Determination. Cell 125, S. 593 - 605 (2006)
  53. Boras-Granic, K.; Chang, H.; Grosschedl, R.; Hamel, P. A.: Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Developmental Biology 295, S. 219 - 231 (2006)
  54. Boras-Granic, K.; Grosschedl, R.; Hamel, P. A.: Genetic interaction between Lef1 and Alx4 is required for early embryonic development. International Journal of Developmental Biology 50, S. 601 - 610 (2006)
  55. Roessler, S.; Grosschedl, R.: Role of transcription factors in commitment and differentiation of early B lymphoid cells. Seminars in Immunology 18, S. 12 - 18 (2006)
  56. 2005
    Kieslinger, M.; Folberth, S.; Dobreva, G.; Dorn, T.; Croci, L.; Erben, R.; Consalez, G. G.; Grosschedl, R.: EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts. Developmental Cell 9, S. 757 - 767 (2005)
  57. Olson, L. E.; Tollkuhn, J.; Scafoglio, C.; Krones, A.; Zhang, J.; Ohgi, K. A.; Wu, W.; Taketo, M. M.; Kemler, R.; Grosschedl, R. et al.; Rose, D.; Li, X.; Rosenfeld, M. G.: Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination. Cell 125, S. 593 - 605 (2005)
  58. Sasaki, T.; Ito, Y.; Xu, X.; Han, J.; Bringas, P.; Maeda, T.; Harold, S. C.; Grosschedl, R.; Chai, Y.: LEF1 is a critical epithelial survival factor during tooth morphogenesis. Developmental Biology 278, S. 130 - 143 (2005)
  59. 2004
    Kokubu, C.; Heinzmann, U.; Kokubu, T.; Sakai, N.; Kubota, T.; Kawai, M.; Wahl, M. B.; Galceran, J.; Grosschedl, R.; Ozono, K. et al.; Imai, K.: Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131, S. 5469 - 5480 (2004)
  60. Medina, K. L.; Pongubala, J. M. R.; Reddy, K. L.; Lancki, D. W.; Dekoter, R.; Kieslinger, M.; Grosschedl, R.; Singh, H.: Assembling a gene regulatory network for specification of the B cell fate. Developmental Cell 7, S. 607 - 617 (2004)
  61. Gregorieff, A.; Grosschedl, R.; Clevers, H.: Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos. EMBO Journal 23, S. 1825 - 1833 (2004)
  62. Galceran, J.; Sustmann, C.; Hsu, S.-C.; Folberth, S.; Grosschedl, R.: LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes & Development 18, S. 2718 - 2723 (2004)
  63. Roth, W.; Sustmann, C.; Kieslinger, M.; Gilmozzi, A.; Irmer, D.; Kremmer, E.; Turck, C.; Grosschedl, R.: PIASy-Deficient Mice Display Modest Deffects in IFN and Wnt Signaling. The Journal of Immunology 173, S. 6189 - 6199 (2004)
  64. 2001
    Sachdev, S.; Bruhn, L.; Sieber, H.; Pichler, A.; Melchior, F.; Grosschedl, R.: PIASy, a nucler matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes and Development 15, S. 3088 - 3103 (2001)
  1. 2005
    Timm, A.; Grosschedl, R.: Wnt Signaling in Lymphopoiesis. In: Molecular Analysis of B Lymphocyte Development and Activation, S. 225 - 252 (Hg. Singh, H.; Grosschedl, R.; Springer Science). Spring- Verlag, Berlin, Germany (2005)

Weitere Publikationen von Rudolf Grosschedl auf Pubmed.

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