Publications

Lawir, D.-F.; Hess, I.; Sikora, K.; Iwanami, N.; Siamishi, I.; Schorpp, M.; Boehm, T.: Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development. Proceedings of the National Academy of Sciences of the United States of America 116, pp. 26759 - 26767 (2019)

Honkoop, H.; de Bakker, D. E.; Aharonov, A.; Kruse, F.; Shakked, A.; Nguyen, P. D.; de Heus, C.; Garric, L.; Muraro, M. J.; Shoffner, A. et al.; Tessadori, F.; Peterson, J. C.; Noort, W.; Bertozzi, A.; Weidinger, G.; Posthuma, G.; Grün, D.; van der Laarse, W. J.; Klumperman, J.; Jaspers, R. T.; Poss, K. D.; van Oudenaarden, A.; Tzahor, E.; Bakkers, J.: Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLife 8, p. e50163 (2019)

Sankowski, R.; Böttcher, C.; Masuda, T.; Geirsdottir, L.; Sagar, S.; Sindram, E.; Seredenina, T.; Muhs, A.; Scheiwe, C.; Shah, M. J. et al.; Heiland, D. H.; Schnell, O.; Grün, D.; Priller, J.; Prinz, M.: Mapping microglia states in the human brain through the integration of high-dimensional techniques. Nature Neuroscience 22, pp. 2098 - 2110 (2019)

Sheikh, B. N.; Bondareva, O.; Guhathakurta, S.; Tsang, T. H.; Sikora, K.; Aizarani, N.; Sagar, S.; Holz, H.; Grün, D.; Hein, L. et al.; Akhtar, A.: Systematic Identification of Cell-Cell Communication Networks in the Developing Brain. iScience 21, pp. 273 - 287 (2019)

Hummel, J. F.; Zeis, P.; Fixemer, J.; Konrad, P.; Schachtrup, C.; Arnold, S. J.; Grün, D.; Tanriver, Y.: Single-cell RNA-sequencing identifies the developmental trajectory of C-Myc-dependent NK1.1^-T-bet⁺. Mucosal immunology: official journal of the Society for Mucosal Immunology 13, pp. 257 - 270 (2019)

Antonova, A.; Hummel, B.; Khavaran, A.; Redhaber, D. M.; Aprile-Garcia, F.; Rawat, P.; Gundel, K.; Schneck, M.; Hansen, E. C.; Mitschke, J. et al.; Mittler, G.; Miething, C.; Sawarkar, R.: Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1. Cell Reports 29, pp. 1645 - 1659 (2019)

Saçma, M.; Pospiech, J.; Bogeska, R.; de Back, W.; Mallm, J.-P.; Sakk, V.; Soller, K.; Marka, G.; Vollmer, A.; Karns, R. et al.; Cabezas-Wallscheid, N.; Trumpp, A.; Méndez-Ferrer, S.; Milsom, M. D.; Mulaw, M. A.; &, H. G.; Florian, M. C.: Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Nature Cell Biology 21, pp. 1309 - 1320 (2019)

Renschler, G.; Gautier, R.; Claudia, V.; Toscano, S.; Arrigoni, L.; Ramírez, F.; Akhtar, A.: Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling. Genes and Development 33, pp. 1591 - 1612 (2019)

Karoutas, A.; Szymanski, W. G.; Rausch, T.; Guhathakurta, S.; Rog-Zielinska, E. A.; Peyronnet, R.; Seyfferth, J.; Chen, H.-R.; de Leeuw, R.; Herquel, B. et al.; Kimura, H.; Mittler, G.; Kohl, P.; Medalia, O.; Korbel, J. O.; Akhtar, A.: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature Cell Biology 21, pp. 1248 - 1260 (2019)

Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.; Zhang, Y.; Flachsmann, L. J.; Field, C. S.; Patterson, A. E.; Scherer, S.; Alfei, F.; Baixauli, F.; Austin, S. K.; Kelly, B.; Matsushita, M.; Curtis, J. D.; Grzes, K. M.; Villa, M.; Corrado, M.; Sanin, D. E.; Qiu, J.; Pällman, N.; Paz, K.; Maccari, M. E.; Blazar, B. R.; Mittler, G.; Büscher, J.; Zehn, D.; Rospert, S.; Pearce, E. J.; Balabanov, S.; Pearce, E. L.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, pp. 352 - 363 (2019)

O'Sullivan, D.: The metabolic spectrum of memory T cells. Immunology and Cell Biology 97, pp. 636 - 646 (2019)

Bhardwaj, V.; Semplicio, G.; Erdogdu, N. U.; Manke, T.; Akhtar, A.: MapCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications 10, p. 3219 (2019)

Cauchy, P.; Kahn-Perlès, B.; Ferrier, P.; Imbert, J.; Lécine, P.: 2HybridTools, a handy software to facilitate clone identification and mutation mapping from yeast two-hybrid screening. PeerJ 7, 7245 (2019)

Caputa, G.; Castoldi, A.; Pearce, E. J.: Metabolic adaptations of tissue-resident immune cells. Nature Immunology 20, pp. 793 - 801 (2019)

Panhale, A.; Richter , F. M.; Ramírez, F.; Shvedunova, M.; Manke, T.; Mittler, G.; Akhtar, A.: CAPRI enables comparison of evolutionary conserved RNA interacting regions. Nature Communications 10, 2682 (2019) (2019)

Sheikh, B.; Guhathakurta, S.; Akhtar, A.: The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. EMBO Reports 20, p. e47360 (2019)

Aizarani, N.; Saviano, A.; Sagar, S.; Mailly , L.; Durand, S.; Herman, J. S.; Pessaux, P.; Baumert , T. F.; Grün, D.: A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature 572, pp. 199 - 204 (2019)

Qiu, J.; Villa, M.; Sanin, P. D. E.; Buck, M. D.; O’Sullivan, D.; Ching, R. W.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Jonathan, D. C.; Kyle, R. L.; Bakker, N. V. T.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, pp. 2063 - 2074 (2019)

Uderhardt, S.; Martins, A. J.; Tsang, J. S.; Lämmermann, T.; Germain, R. N.: Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177, pp. 541 - 555 (2019)

Klein-Geltink, R.; Pearce , E. L.: The Importance of methionine metabolism. eLife 8, p. e47221 (2019)

O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, pp. 324 - 334 (2019)

Cameron, A. M.; Castoldi, A.; Sanin, D. E.; Flachsmann, L. J.; Field, C. S.; Puleston, D. J.; Kyle, R. L.; Patterson, A.; Hassler, F.; Buescher, J. M. et al.; Kelly, B.; Pearce, E. L.; Pearce, E. J.: Inflammatory macrophage dependence on NAD⁺ salvage is a consequence of reactive oxygen species-mediated DNA damage. Nature Immunology 20, pp. 420 - 432 (2019)

Hörner, M.; Raute, K.; Hummel, B.; Madl, J.; Creusen, G.; Thomas, O. S.; Christen, E. H.; Hotz, N.; Gübeli, R. J.; Engesser, R. et al.; Rebmann, B.; Lauer, J.; Rolauffs, B.; Timmer, J.; Schamel, W. W. A.; Pruszak, J.; Römer, W.; Zurbriggen, M. D.; Friedrich, C.; Walther, A.; Minguet, S.; Sawarkar, R.; Weber, W.: Phytochrome-Based Extracellular Matrix with Reversibly Tunable mechanical Properties. Advanced Materials 31, p. e1806727 (2019)

Baixauli Celda, F.; Villa, M.; Pearce, E. L.: Potassium shapes antitumor immunity. Science 363, pp. 1395 - 1396 (2019)

Lam, K.-C.; Chung, H.-R.; Semplicio, G.; Iyer, S. S.; Gaub, A.; Bhardwaj, V.; Holz, H.; Georgiev, P.; Akhtar, A.: The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes and Development 33, pp. 453 - 465 (2019)

Wilhelm, I.; Levit-Zerdoun, E.; Jakob, J.; Villringer, S.; Frensch, M.; Übelhart, R.; Landi, A.; Müller, P.; Imberty, A.; Thuenauer, R. et al.; Claudinon, J.; Jumaa, H.; Reth, M.; Eibel, H.; Hobeika, E.; Römer, W.: Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins. Science Signaling 12, p. eaao7194 (2019)

Mauler, M.; Herr, N.; Schoenichen, C.; Witsch, T.; Marchini, T.; Härdtner, C.; Koentges, C.; Kienle, K.; Ollivier, V.; Schell, M. et al.; Dorner, L.; Wippel, C.; Stallmann, D.; Normann, C.; Bugger, H.; Walther, P.; Wolf, D.; Ahrens, I.; Lämmermann, T.; Ho-Tin-Noé, B.; Ley, K.; Bode, C.; Hilgendorf, I.; Duerschmied, D.: Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Circulation 139, pp. 918 - 931 (2019)

Aprile-Garcia, F.; Parul, T.; Hummel, B.; Khavaran, A.; Sawarkar, R.: Nascent-protein ubiquitination is required for heat shock-induced gene downregulation in human cells. Nature Structural and Molecular Biology 26, pp. 137 - 146 (2019)

Masuda, T.; Sankowski, R.; Staszewski, O.; Böttcher, C.; Amann, L.; Sagar, S.; Scheiwe, C.; Nessler, S.; Kunz, P.; van Loo, G. et al.; Coenen, V. A.; Reinacher, P. C.; Michel, A.; Sure, U.; Gold, R.; Grün, D.; Priller, J.; Stadelmann, C.; Prinz, M.: Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 566, pp. 388 - 392 (2019)

Jordão, M. J. C.; Sankowski, R.; Brendecke, S. M.; Sagar, S.; Locatelli, G.; Tai, Y.-H.; Tay, T. L.; Schramm, E.; Armbruster, S.; Hagemeyer, N. et al.; Groß, O.; Mai, D.; Çiçek, Ö.; Falk, T.; Kerschensteiner, M.; Grün, D.; Prinz, M.: Single-cell profiling identifies myeloid cell subsets with distinct fates during neuro inflammation. Science 363 (2019)