Publications

Mossad, O.; Nent, E.; Woltemate, S.; Folschweiller, S.; Büscher, J. M.; Schnepf, D.; Erny, D.; Staeheli, P.; Bartos, M.; Szalay, A. et al.; Stecher, B.; Vital, M.; Sauer, J. F.; Lämmermann, T.; Prinz, M.; Blank, T.: Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline. Nature aging 1, pp. 1127 - 1136 (2021)

Challen, G. A.; Pietras, E. M.; Cabezas-Wallscheid, N.; Signer, R. A. J.: Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification. Experimental Hematology 104, pp. 55 - 63 (2021)

Ibarra-Morales, D.; Rauer, M.; Quarato, P.; Rabbani, L.; Zenk, F.; Schulte-Sasse, M.; Cardamone, F.; Gomez-Auli, A.; Cecere, G.; Iovino, N.: Histone variant H2A.Z regulates zygotic genome activation. Nature Communications 12, 7002 (2021)

Castro Alvarez, J. J.; Revel, M.; Carrasco Sala, J.; Cléard, F.; Pauli, D.; Hilgers, V.; Karch, F.; Maeda, R. K.: Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference. PLoS Genetics 17 (11), e1009843 (2021)

Roy, R.; Ramamoorthy, S.; Shapiro, B. D.; Kaileh, M.; Hernandez, D.; Sarantopoulou, D.; Arepalli, S.; Boller, S.; Singh, A.; Bektas, A. et al.; Kim, J.; Moore, A. Z.; Tanaka, T.; McKelvey, J.; Zukley, L.; Nguyen, C.; Wallace, T.; Dunn, C.; Wersto, R.; Wood, W.; Piao, Y.; Becker, K. G.; Coletta, C.; De, S.; Sen, J. M.; Battle, A.; Weng, N.-p.; Grosschedl, R.; Ferrucci, L.; Sen, R.: DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity. Immunity 54, pp. 2465 - 2480 (2021)

Lalioti, M.-E.; Rettkowski, J.; Cabezas-Wallscheid, N.: Avoid shocking your hematopoietic stem cells to keep them young and growing. Cell Stem Cell 28, pp. 1887 - 1889 (2021)

Llaó-Cid, L.; Roessner, P. M.; Chapaprieta, V.; Öztürk, S.; Roider, T.; Bordas, M.; Izcue, A.; Colomer, D.; Dietrich, S.; Stilgenbauer, S. et al.; Hanna, B.; Martín-Subero, J. I.; Seiffert, M.: EOMES is essential for antitumor activity of CD8⁺ T cells in chronic lymphocytic leukemia. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 35, pp. 3152 - 3162 (2021)

Pessoa Rodrigues, C.; Chatterjee, A.; Wiese, M.; Stehle, T.; Szymanski, W. G.; Shvedunova, M.; Akhtar, A.: Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice. Nature Communications 12, 6212 (2021)

O’Meara, C. P.; Guerri, L.; Lawir, D.-F.; Mateos, F.; Iconomou, M.; Iwanami, N.; Soza-Ried, C.; Sikora, K.; Siamishi, I.; Giorgetti, O. B. et al.; Peter, S.; Schorpp, M.; Boehm, T.: Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications Biology 4, 1201 (2021)

Glaser, K. M.; Mihlan, M.; Lämmermann, T.: Positive feedback amplification in swarming immune cell populations. Current Opinion in Cell Biology 72, pp. 156 - 162 (2021)

Pessoa Rodrigues, C.; Akhtar, A.: Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells. Science Advances 7 (32), eabi5987 (2021)

Montavon, T.; Shukeir, N.; Erikson, G.; Engist, B.; Onishi-Seebacher, M.; Ryan, D.; Musa, Y.; Mittler, G.; Meyer, A. G.; Genoud, C. et al.; Jenuwein, T.: Complete loss of H3K9 methylation dissolves mouse heterochromatin organization. Nature Communications 12, 4359 (2021)

Keller Valsecchi, C. I.; Marois, E.; Basilicata, M. F.; Georgiev, P.; Akhtar, A.: Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life science alliance 4, e202000996 (2021)

Barkaway, A.; Rolas, L.; Joulia, R.; Bodkin, J.; Lenn, T.; Owen-Woods, C.; Reglero-Real, N.; Stein, M.; Vázquez-Martínez, L.; Girbl, T. et al.; Poston, R. N.; Golding, M.; Saleeb, R. S.; Thiriot, A.; von Andrian, U. H.; Duchene, J.; Voisin, M.-B.; Bishop, C. L.; Voehringer, D.; Roers, A.; Rot, A.; Lämmermann, T.; Nourshargh, S.: Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 54, pp. 1494 - 1510 (2021)

Clapes, T.; Polyzou, A.; Prater, P.; Sagar; Morales-Hernández, A.; Ferrarini, M. G.; Kehrer, N.; Lefkopoulos, S.; Bergo, V.; Hummel, B. et al.; Obier, N.; Maticzka, D.; Bridgeman, A.; Herman, J. S.; Ilik, I.; Klaeylé, L.; Rehwinkel, J.; McKinney-Freeman, S.; Backofen, R.; Akhtar, A.; Cabezas-Wallscheid, N.; Sawarkar, R.; Rebollo, R.; Grün, D.; Trompouki, E.: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature Cell Biology 23, pp. 704 - 717 (2021)

Antonio Urrutia, G.; Ramachandran, H.; Cauchy, P.; Boo, K.; Ramamoorthy, S.; Boller, S.; Dogan, E.; Clapes, T.; Trompouki, E.; Torres-Padilla, M.-E. et al.; Palvimo, J. J.; Pichler, A.; Grosschedl, R.: ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Genes and Development 35, pp. 1143 - 1160 (2021)

Spiecker, L.; Witte, I.; Mehlig, J.; Shah, V.; Meyerhöfer, M.; Haehnel, P. S.; Petermann, V.; Schüler, A.; More, P.; Cabezas-Wallscheid, N. et al.; Horke, S.; Pautz, A.; Daiber, A.; Sasca, D.; Kindler, T.; Kleinert, a. H.: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis. Oxidative medicine and cellular longevity, 3917028 (2021)

Sommerkamp, P.; Cabezas-Wallscheid, N.; Trumpp, A.: Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation. Trends in Molecular Medicine 27, pp. 660 - 672 (2021)

Kienle, K.; Glaser, K. M.; Eickhoff, S.; Mihlan, M.; Knöpper, K.; Reátegui, E.; Epple, M. W.; Gunzer, M.; Baumeister, R.; Tarrant, T. K. et al.; Germain, R. N.; Irimia, D.; Kastenmüller, W.; Lämmermann, T.: Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372, eabe7729 (2021)

Sommerkamp, P.; Romero-Mulero, M. C.; Narr, A.; Ladel, L.; Hustin, L.; Schönberger, K.; Renders, S.; Altamura, S.; Zeisberger, P.; Jäcklein, K. et al.; Klimmeck, D.; Rodriguez-Fraticelli, A.; Camargo, F. D.; Perié, L.; Trumpp, A.; Cabezas-Wallscheid, N.: Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells. Blood 137, pp. 3218 - 3224 (2021)

Duda, K. J.; Ching, R. W.; Jerabek, L.; Shukeir, N.; Erikson, G.; Engist, B.; Onishi-Seebacher, M.; Perrera, V.; Richter, F.; Mittler, G. et al.; Fritz, K.; Helm, M.; Knuckles, P.; Bühler, M.; Jenuwein, T.: m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin. Nucleic Acids Research (London) 49, pp. 5568 - 5587 (2021)

Arasa, J.; Collado-Diaz, V.; Kritikos, I.; Medina-Sanchez, J. D.; Friess, M. C.; Sigmund, E. C.; Schineis, P.; Hunter, M. C.; Tacconi, C.; Paterson, N. et al.; Nagasawa, T.; Kiefer, F.; Makinen, T.; Detmar, M.; Moser, M.; Lämmermann, T.; Halin, C.: Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation. Journal of Experimental Medicine 218, p. e20201413 (2021)

Zenk, F.; Zhan, Y.; Kos, P.; Löser, E.; Atinbayeva, N.; Schächtle, M.; Tiana, G.; Giorgetti, L.; Iovino, N.: HP1 drives de novo 3D genome reorganization in early Drosophila embryos. Nature 593, pp. 289 - 293 (2021)

Tiago, T.; Hummel, B.; Morelli, F. F.; Basile, V.; Vinet, J.; Galli, V.; Mediani, L.; Antoniani, F.; Pomella, S.; Cassandri, M. et al.; Garone, M. G.; Silvestri, B.; Cimino, M.; Cenacchi, G.; Costa, R.; Mouly, V.; Poser, I.; Yeger-Lotem, E.; Rosa, A.; Alberti, S.; Rota, R.; Ben-Zvi, A.; Sawarkar, R.; Carra, S.: Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Cell Death and Disease 12, 452 (2021)

Dudek, M.; Pfister, D.; Donakonda, S.; Filpe, P.; Schneider, A.; Laschinger, M.; Hartmann, D.; Hüser, N.; Meiser, P.; Bayerl, F. et al.; Inverso, D.; Wigger, J.; Sebode, M.; Öllinger, R.; Rad, R.; Hegenbarth, S.; Anton, M.; Guillot, A.; Bowman, A.; Heide, D.; Müller, F.; Ramadori, P.; Leone, V.; Garcia-Caceres, C.; Gruber, T.; Seifert, G.; Kabat, A.; Malm, J.-P.; Reider, S.; Effenberger, M.; Roth, S.; Billeter, A. T.; Müller-Stich, B.; Pearce, E. J.; Koch-Nolte, F.; Käser, R.; Tilg, H.; Thimme, R.; Böttler, T.; Tacke, F.; Dufour, J.-F.; Haller, D.; Murray, P. J.; Heeren, R.; Zehn, D.; Böttcher, J. P.; Knolle, M. H. P. A.: Auto-aggressive CXCR6 CD8 T cells cause liver immune pathology in NASH. Nature 592, pp. 444 - 449 (2021)

Akerman, I.; Maestro, M. A.; Franco, E. D.; Grau, V.; Flanagan, S.; García-Hurtado, J.; Mittler, G.; Ravassard, P.; Piemonti, L.; Ellard, S. et al.; Hattersley, A. T.; Ferrer, J.: Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Cell Reports 35, 108981 (2021)

Villa, M.; O'Sullivan, D.; Pearce, E. L.: Glucose makes T_reg lose their temper. Cancer Cell 39, pp. 460 - 462 (2021)

Stanczak, M. A.; Sanin, P. D. E.; Apostolova, P.; Nerz, G.; Lampaki, D.; Hofmann, M.; Steinmann, D.; Krohn-Grimberghe, M.; Thimme, R.; Mittler, G. et al.; Waller, C. F.; Pearce, E. J.; Pearce, E. L.: IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications 12, 2133 (2021)

Mohr, T.; Katz, S.; Paulitschke, V.; Aizarani, N.; Tolios, A.: Systematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Several Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma. Cancers / Molecular Diversity Preservation International (MDPI) 13, 1768 (2021)

Schoels, M.; Zhuang, M.; Fahrner, A.; Kuechlin, S.; Sagar, S.; Franz, H.; Schmitt, A.; Walz, G.; Yakulov, T. A.: Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development. American Journal of Physiology-Renal Physiology 320, pp. F826 - F837 (2021)