Publications

2015

Journal Article

Busch, K.; Klapproth, K.; Barile, M.; Flossdorf, M.; Holland-Letz, T.; Schlenner, S. M.; Reth, M.; Höfer, T.; Rodewald, H.-R.: Fundamental properties of unperturbed haematopoiesis from stem cell in vivo. Nature 518, pp. 542 - 546 (2015)

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Lin , M. I.; Emily N., P.; Boatmann, S.; Hagedorn, E. J.; Trompouki, E.; Satishchandran, S.; Carspecken, C. W.; Uong, A.; DiBiase, A.; Yang, S. et al.; Canver, M. C.; Dahlberg, A.; Lu , Z.; Zhang, C. C.; Orkin, S. H.; Bernstein, I. D.; Aster, J. C.; White, R. M.; Zon, L. I.: Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. eLIFE 4, p. e05544 (2015)

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Hobeika, E.; Nielsen, P. J.; Medgysi, D.: Signaling mechanisms regulating B-lymphocyte activation and tolerance. Journal of Molecular Medicine 93, pp. 143 - 158 (2015)

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Königsberger, S.; Weis, V.; Prodöhl, J.; Stehling, M.; Hobeika, E.; Reth, M.; Kiefer, F.: Suboptimal B-cell antigen receptor signaling activity in vivo elicits germina center counterselection mechanisms. European Journal of Immunology 45, pp. 603 - 611 (2015)

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O'Sullivan, D.; Pearce, E. L.: Targeting T cell metabolism for therapy. Trends in Immunology 36, pp. 71 - 80 (2015)

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Oktaba, K.; Zhang, W.; Lotz, T. S.; Jun, D. J.; Lemke, S. B.; Ng, S. P.; Esposito, E.; Levine, M.; Hilgers, V.: ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervious system. Molecular Cell 57, pp. 341 - 348 (2015)

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Blagih, J.; Coulombe, F.; Vincent, E. E.; Dupuy, F.; Galicia-Vázquez, G.; Yurchenko, E.; Raissi, T. C.; van der Windt, G. J.W.; Viollet, B.; Pearce, E. L. et al.; Pelletier, J.; Piccirillo, C. A.; Krawczyk, C. M.; Divangahi, M.; Jones, R. G.: The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vitro. Immunity 42, pp. 41 - 54 (2015)

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Krönig, M.; Walter, M.; Drendel, V.; Werner, M.; Julg, C. A.; Richter, A.; Backofen, R.; McGarry, D.; Follo, M.; Schultze-Seemann, W. et al.; Schüle, R.: Cell type specific gene expression analysis of prostate needle biopsies resolves tumor tissue heterogeneity. Oncotarget 6, pp. 1302 - 1314 (2015)

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Tsujimura, T.; Klein, F. A.; Langenfeld, K.; Glaser, J.; Huber, W.; Spitz, F.: A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes. PLOS Genetics 11, e1004897 (2015)

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Bu, H.; Narisu, N.; Schlick, B.; Rainer, J.; Manke, T.; Schäfer, G.; Pasqualini, L.; Chines, P.; Schweiger, M. R.; Fuchsberger, C. et al.; Klocker , H.: Putatative Prostate Cancer Risk SNP in an Androgen Receptor-binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites. Human Mutations 37, pp. 52 - 64 (2015)

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Hilgers, V.: Alternative polyadenylation couples to transcription initiation: Insights from ELAV-mediated 3' UTR extension. RNA Biology 12, pp. 918 - 921 (2015)

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Jha, A.K.; Huang, S.C.; Sergushichev, A.; Lampropoulo, V.; Ivanova , Y.; Loginicheva , E.; Chielewski, K.; Stewart, K.M.; Ashali, J.; Everts, B. et al.; Pearce, E.J.; Driggers, E.M.; Artyomov, A.: Network integration of parallel metabolomics and transcirptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42, pp. 419 - 430 (2015)

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Monin, L.; Griffiths, K. L.; Lam, W. Y.; Gopal, R.; Kang, D. D.; Ahmed, M.; Rajamanickam, A.; Cruz-Lagunas, A.; Zúñiga, J.; Babu, S. et al.; Kolls, J. K.; Mitreva, M.; Rosa, B. A.; Ramos-Payan, R.; Morrison, T. E.; Murray, P. J.; Rangel-Moreno, J.; Pearce, E. J.; Khader, S. A.: Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. Journal of Clinical Investigation 125, pp. 4699 - 4713 (2015)

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Pearce, E. J.; Everts, B.: Dendritic cell metabolism. Nature Reviews Immunology, pp. 18 - 29 (2015)

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Pearce, E. J.; Huang, S. C.-C.: The metabolic control of schistosome egg production. Cellular Microbiology 17, pp. 796 - 801 (2015)

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Rambold, A.; Cohen, S.; Lippencott-Schwartz, J.: Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, authophagy and mitochondrial fusion dynamics. Developmental Cell 32, pp. 678 - 692 (2015)

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2014

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Sone, K.; Piao, L.; Nakakido, M.; Ueda, K.; Jenuwein, T.; Nakamura, Y.; Hamamoto, R.: Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nature Communications 5, 5691 (2014), p. 5691 (2014)

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Oest, A.; Lempradl, A.; Casas, E.; Weigert, M.; Tiko, T.; Deniz, M.; Pantano, L.; Boenisch, U.; Itskov, P. M.; Stoeckius, M. et al.; Ruf, M.; Rajewsky, N.; Reuter, G.; Iovino, N.; Ribiero, C.; Alenius, M.; Heyne, S.; Vavouri, T.; Pospisilik, J. A.: Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity. Cell 159, pp. 1352 - 1364 (2014)

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Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L. et al.; Green, D. R.; Jones, D. P.; Virgin, H. W.; Ahmed, R.; Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L.; Green, D. R.; Jones, D. P.; Ahmed, R.: Autophagy is essential for effector CD8⁺ T cell survival and memory formation. Nature Immunology 15, pp. 1152 - 1161 (2014)

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O'Sullivan, D.; Pearce, E. L.: Fatty acid sysnthesis tips the TH17-Treg cell balance. Nature Medicine 20, pp. 1235 - 1236 (2014)

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Walsh, M. C.; Pearce, E. L.; Cejas, P. J.; Lee, J.; Wang, L.-S.; Choi, Y.: IL-18 synergivzes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals. The Journal of Immunology 193, pp. 3992 - 4001 (2014)

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Das, S.; Li, J.; Holland, S. J.; Iyer, L. M.; Hirano, M.; Schorrp, M.; Aravind, L.; Cooper, M. D.; Boehm, T.: Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates. Proceedings of the National Academy of Sciences of the United States of America 111, pp. 14828 - 14833 (2014)

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Holland, S. J.; Gao, M.; Hirano, M.; Iyer, L. M.; Luo, M.; Schorpp, M.; Cooper, M. D.; Aravind, L.; Mariuzza, R. A.; Boehm, T.: Selection of the lamprey VLRC antigen receptor repertoire. Proceedings of the National Academy of Sciences of the United States of America 111, pp. 14834 - 14839 (2014)

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Amiel, E.; Everts, B.; Fritz, D.; Beauchamp, S.; Ge, B.; Pearce, E. L.; Pearce, E. J.: Mechanistic target of rapamycin inhition extend cellular lifespan in dendritic cells by preserving mitochondrial function. The Journal of Immunology 193, pp. 2821 - 2830 (2014)

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Eierhoff, T.; Bastian, B.; Thuenauer, R.; Madl, J.; Audfray, A.; Aigal, S.; Juillot, S.; Rydell, G. E.; Müller, S.; de Bentzmann, S. et al.; Imberty, A.; Fleck, C.; Römer, W.: A lipid zipper triggers bacterial invasion. Proceedings of the National Academy of Sciences, USA, pp. 12895 - 12900 (2014)

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Boller, S.; Grosschedl, R.: The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function. Immunological Reviews 261, pp. 102 - 115 (2014)

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Chou, C.; Pinto, A. K.; Jonathen, C.; Persaud, S. P.; Cella, M.; Lin, C.-C.; Edelson, B. T.; Allen, P. M.; Colonna, M.; Pearce, E. L. et al.; Diamond, M. S.; Egawa, T.: c-Myc-induced transcription factor AP4 is requeired for host protection mediated by CD8⁺ T Cells. Nature Immunology 15, pp. 884 - 893 (2014)

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Huang, S. C.-C.; Everts, B.; Ivanova, Y.; O'Sullivan, D.; Nascimento, M.; Smith, A. M.; Beatty, W.; Love-Gregory, L.; Lam, W. Y.; O'Neill, C. M. et al.; Yan, C.; Du, H.; Abumrad, N. A.; Urban, J. F. J.; Artyomov, M. N.; Pearce, E. J.; Pearce, E. L.: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 15, pp. 846 - 855 (2014)

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Swann, J. B.; Weyn, A.; Nagakubo, D.; Bleul, C. C.; Toyoda, A.; Happe, C.; Netuschil, N.; Hess, I.; Haas-Assenbaum, A.; Taniguchi, Y. et al.; Schorpp, M.; Boehm, T.: Conversion of the Thymus into a Bipotent Lymphoid Organ by Replacement of Foxn1 with its Paralog Foxn4. Cell Reports 8, pp. 1184 - 1197 (2014)

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Furdas, S. D.; Hoffmann, I.; Robaa, D.; Herquel, B.; Malinka, W.; Świątek, P.; Akhtar, A.; Sippl, W.; Jung, M.: Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs). Medicinal Chemistry Communications 5, pp. 1856 - 1862 (2014)

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Journal Article (1594)